Search Results - "Derecki, Noel C."

Methyl-CpG Binding Protein 2 Regulates Microglia and Macrophage Gene Expression in Response to Inflammatory Stimuli by Cronk, James C., Derecki, Noël C., Ji, Emily, Xu, Yang, Lampano, Aaron E., Smirnov, Igor, Baker, Wendy, Norris, Geoffrey T., Marin, Ioana, Coddington, Nathan, Wolf, Yochai, Turner, Stephen D., Aderem, Alan, Klibanov, Alexander L., Harris, Tajie H., Jung, Steffen, Litvak, Vladimir, Kipnis, Jonathan

“…Mutations in MECP2, encoding the epigenetic regulator methyl-CpG-binding protein 2, are the predominant cause of Rett syndrome, a disease characterized by both…”
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Structural and functional features of central nervous system lymphatic vessels by Louveau, Antoine, Smirnov, Igor, Keyes, Timothy J., Eccles, Jacob D., Rouhani, Sherin J., Peske, J. David, Derecki, Noel C., Castle, David, Mandell, James W., Lee, Kevin S., Harris, Tajie H., Kipnis, Jonathan

“…The central nervous system undergoes constant immune surveillance, but the route that immune cells take to exit the brain has been unclear as it had been…”
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Alternatively activated myeloid (M2) cells enhance cognitive function in immune compromised mice by Derecki, Noel C, Quinnies, Kayla M, Kipnis, Jonathan

“…Abstract It was recently shown that adaptive immunity plays a key role in cognitive function. T cells appear to be major players in learning and memory; thus,…”
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Unexpected cellular players in Rett syndrome pathology by Cronk, James C, Derecki, Noel C, Litvak, Vladimir, Kipnis, Jonathan

“…Abstract Rett syndrome is a devastating neurodevelopmental disorder, primarily caused by mutations of methyl CpG-binding protein 2 (MeCP2). Although the…”
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Pro-cognitive properties of T cells by Kipnis, Jonathan, Gadani, Sachin, Derecki, Noël C.

“…Can the immune system influence how our brain works? Here, Jonathan Kipnis and colleagues discuss the emerging hypothesis that T cells, and in particular their…”
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Role of neuro-immunological factors in the pathophysiology of mood disorders by Bhattacharya, Anindya, Derecki, Noel C., Lovenberg, Timothy W., Drevets, Wayne C.

“…Mood disorders, despite the widespread availability of monoamine-based antidepressant treatments, are associated with persistently high rates of disability,…”
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Wild-type microglia arrest pathology in a mouse model of Rett syndrome by Derecki, Noël C., Cronk, James C., Lu, Zhenjie, Xu, Eric, Abbott, Stephen B. G., Guyenet, Patrice G., Kipnis, Jonathan

“…Transplanting bone marrow from wild-type mice into MECP2-lacking mice results in wild-type microglial engraftment, extends lifespan and reduces symptoms of…”
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Regulation of learning and memory by meningeal immunity: a key role for IL-4 by Derecki, Noël C, Cardani, Amber N, Yang, Chun Hui, Quinnies, Kayla M, Crihfield, Anastasia, Lynch, Kevin R, Kipnis, Jonathan

“…Proinflammatory cytokines have been shown to impair cognition; consequently, immune activity in the central nervous system was considered detrimental to…”
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Retraction Note: From neurons to microglia, with complements by Derecki, Noël C., Kipnis, Jonathan

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High-throughput-compatible assays using a genetically-encoded calcium indicator by Wu, Nyantsz, Nishioka, Walter K., Derecki, Noël C., Maher, Michael P.

“…Measurement of intracellular calcium in live cells is a key component of a wide range of basic life science research, and crucial for many high-throughput…”
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Microglia as a critical player in both developmental and late-life CNS pathologies by Derecki, Noël C., Katzmarski, Natalie, Kipnis, Jonathan, Meyer-Luehmann, Melanie

“…Microglia, the tissue-resident macrophages of the brain, are attracting increasing attention as key players in brain homeostasis from development through…”
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The role of microglia in brain maintenance: implications for Rett syndrome by Derecki, Noël C, Cronk, James C, Kipnis, Jonathan

“…The role of microglia in central nervous system (CNS) pathology has been studied extensively, and more recently, examination of microglia in the healthy brain…”
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From neurons to microglia, with complements by Derecki, Noël C, Kipnis, Jonathan

“…A study in this issue of Nature Neuroscience demonstrates that astrocytic transforming growth factor-[beta] facilitates complement-mediated removal of weak…”
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Correction: Corrigendum: Structural and functional features of central nervous system lymphatic vessels by Louveau, Antoine, Smirnov, Igor, Keyes, Timothy J., Eccles, Jacob D., Rouhani, Sherin J., Peske, J. David, Derecki, Noel C., Castle, David, Mandell, James W., Lee, Kevin S., Harris, Tajie H., Kipnis, Jonathan

“…Nature 523, 337–341 (2015); doi:10.1038/nature14432 We would like to correct this Letter, which demonstrated the molecular characteristics and functional…”
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RETRACTED ARTICLE: From neurons to microglia, with complements by Derecki, Noël C, Kipnis, Jonathan

“…A study in this issue of Nature Neuroscience demonstrates that astrocytic transforming growth factor-β facilitates complement-mediated removal of weak synapses…”
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From neurons to microglia, with complements: a study in this issue of Nature Neuroscience demonstrates that astrocytic transforming growth factor-β facilitates complement-mediated removal of weak synapses by microglia during the synaptic pruning period by Derecki, Noel C, Kipnis, Jonathan

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Corrigendum: Structural and functional features of central nervous system lymphatic vessels by Louveau, Antoine, Smirnov, Igor, Keyes, Timothy J, Eccles, Jacob D, Rouhani, Sherin J, Peske, J David, Derecki, Noel C, Castle, David, Mandell, James W, Lee, Kevin S, Harris, Tajie H, Kipnis, Jonathan

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Structural and functional features of central nervous system lymphatics by Louveau, Antoine, Smirnov, Igor, Keyes, Timothy J., Eccles, Jacob D., Rouhani, Sherin J., Peske, J. David, Derecki, Noel C., Castle, David, Mandell, James W., Kevin, S. Lee, Harris, Tajie H., Kipnis, Jonathan

“…One of the characteristics of the CNS is the lack of a classical lymphatic drainage system. Although it is now accepted that the CNS undergoes constant immune…”
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