Genetic Evidence for an Ethnic Diversity in the Susceptibility to Ménière’s Disease

BACKGROUNDMénière’s disease (MD) is a debilitating disorder of the inner ear characterized by cochlear and vestibular dysfunction. The cause of this disease is still unknown, and epidemiological data for MD are sparse. From the existing literature, women seem to be more susceptible than men, and Cau...

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Published in:	Otology & neurotology Vol. 34; no. 7; pp. 1336 - 1341
Main Authors:	Ohmen, Jeffrey Douglass, White, Cory H, Li, Xin, Wang, Juemei, Fisher, Laurel M, Zhang, Huan, Derebery, Mary Jennifer, Friedman, Rick A
Format:	Journal Article
Language:	English
Published:	United States Copyright by Otology & Neurotology, Inc. Image copyright Wolters Kluwer Health/Anatomical Chart Company 01-09-2013
Subjects:	Adolescent Adult African Continental Ancestry Group Age of Onset Aged Asian Continental Ancestry Group Child Cluster Analysis Cohort Studies Data Interpretation, Statistical DNA - genetics DNA - isolation & purification Epidemiologic Methods Ethnic Groups European Continental Ancestry Group Female Genetic Predisposition to Disease - epidemiology Genome, Human - genetics Genotype Hispanic Americans Humans Male Meniere Disease - genetics Middle Aged Principal Component Analysis Sex Characteristics Young Adult
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Summary:	BACKGROUNDMénière’s disease (MD) is a debilitating disorder of the inner ear characterized by cochlear and vestibular dysfunction. The cause of this disease is still unknown, and epidemiological data for MD are sparse. From the existing literature, women seem to be more susceptible than men, and Caucasians seem to be more susceptible than Asians. OBJECTIVEIn this article, we characterize a large definite MD cohort for sex and age of onset of disease and use molecular genetic methodologies to characterize ethnicity. STUDY DESIGNMedical record review for sex and age of onset. Ancestry analysis compared results from the principal component analysis of whole-genome genotype data from MD patients to self-identified ancestry in control samples. SETTINGHouse Clinic in Los Angeles. PATIENTSDefinitive MD patients. RESULTSOur review of medical records for definitive MD patients reveals that women are more susceptible than men. We also find that men and women have nearly identical age of onset for disease. Lastly, interrogation of molecular genetic data with principal component analysis allowed detailed observations about the ethnic ancestry of our patients. Comparison of the ethnicity of MD patients presenting to our tertiary care clinic with the self-recollected ethnicity of all patients visiting the clinic revealed an ethnic bias, with Caucasians presenting at a higher frequency than expected and the remaining major ethnicities populating Los Angeles (Hispanics, Blacks, and Asians) presenting at a lower frequency than expected. CONCLUSIONTo the best of our knowledge, this report is the first ethnic characterization of a large MD cohort from a large metropolitan region using molecular genetic data. Our data suggest that there is a bias in sex and ethnic susceptibility to this disease.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1531-7129 1537-4505
DOI:	10.1097/MAO.0b013e3182868818