Search Results - "Derebail, Suchitra S"

Generation of site-specific retargeting platform cell lines for drug discovery using phiC31 and R4 integrases by Lieu, Pauline T, Machleidt, Thomas, Thyagarajan, Bhaskar, Fontes, Andrew, Frey, Elizabeth, Fuerstenau-Sharp, Maya, Thompson, David V, Swamilingiah, Geetha M, Derebail, Suchitra S, Piper, David, Chesnut, Jonathan D

“…One of the challenges in developing cell lines for high-throughput screening in drug discovery is the labor- and time-intensive process required to create…”
Get more information

Mechanistic Analysis of Pause Site-dependent and -independent Recombinogenic Strand Transfer from Structurally Diverse Regions of the HIV Genome by Derebail, Suchitra S, DeStefano, Jeffrey J

“…Retroviral recombinants are generated by strand transfers occurring within internal regions of the viral genome and are a major source of genetic variability…”
Get full text

Differing Roles of the N- and C-terminal Zinc Fingers in Human Immunodeficiency Virus Nucleocapsid Protein-enhanced Nucleic Acid Annealing by Heath, Megan J., Derebail, Suchitra S., Gorelick, Robert J., DeStefano, Jeffrey J.

“…The replication process of human immunodeficiency virus requires a number of nucleic acid annealing steps facilitated by the hybridization and…”
Get full text

Evidence for the Differential Effects of Nucleocapsid Protein on Strand Transfer in Various Regions of the HIV Genome by Derebail, Suchitra S., Heath, Megan J., DeStefano, Jeffrey J.

“…An in vitro strand transfer assay that mimicked recombinational events occurring during reverse transcription in HIV-1 was used to assess the role of…”
Get full text

Influence of viral nucleocapsid protein and genomic RNA structural intricacies on the mechanism of HIV recombination by Derebail, Suchitra S

“…Internal strand transfers involve template switching during retroviral replication, within internal regions of the viral genome. Such transfers are a major…”
Get full text