Search Results - "Derde, Sarah"

Effect of tolerating macronutrient deficit on the development of intensive-care unit acquired weakness: a subanalysis of the EPaNIC trial by Hermans, Greet, MD, Casaer, Michael P, MD, Clerckx, Beatrix, PT, Güiza, Fabian, PhD, Vanhullebusch, Tine, PT, Derde, Sarah, PhD, Meersseman, Philippe, MD, Derese, Inge, BSc, Mesotten, Dieter, MD, Wouters, Pieter J, MSc, Van Cromphaut, Sophie, MD, Debaveye, Yves, MD, Gosselink, Rik, PhD, Gunst, Jan, MD, Wilmer, Alexander, MD, Van den Berghe, Greet, Dr MD, Vanhorebeek, Ilse, PhD

“…Summary Background Patients who are critically ill can develop so-called intensive-care unit acquired weakness, which delays rehabilitation. Reduced muscle…”
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Adipose tissue protects against sepsis-induced muscle weakness in mice: from lipolysis to ketones by Goossens, Chloë, Weckx, Ruben, Derde, Sarah, Dufour, Thomas, Vander Perre, Sarah, Pauwels, Lies, Thiessen, Steven E, Van Veldhoven, Paul P, Van den Berghe, Greet, Langouche, Lies

“…ICU-acquired weakness is a debilitating consequence of prolonged critical illness that is associated with poor outcome. Recently, premorbid obesity has been…”
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The role of pro-opiomelanocortin in the ACTH-cortisol dissociation of sepsis by Téblick, Arno, Vander Perre, Sarah, Pauwels, Lies, Derde, Sarah, Van Oudenhove, Tim, Langouche, Lies, Van den Berghe, Greet

“…Sepsis is typically hallmarked by high plasma (free) cortisol and suppressed cortisol breakdown, while plasma adrenocorticotropic hormone (ACTH) is not…”
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Efficacy and safety of ketone ester infusion to prevent muscle weakness in a mouse model of sepsis-induced critical illness by Weckx, Ruben, Goossens, Chloë, Derde, Sarah, Pauwels, Lies, Vander Perre, Sarah, Van den Berghe, Greet, Langouche, Lies

“…In septic mice, 3-hydroxybutyrate-sodium-salt has shown to partially prevent sepsis-induced muscle weakness. Although effective, the excessive sodium load was…”
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Insufficient Activation of Autophagy Allows Cellular Damage to Accumulate in Critically Ill Patients by Vanhorebeek, Ilse, Gunst, Jan, Derde, Sarah, Derese, Inge, Boussemaere, Magaly, Güiza, Fabian, Martinet, Wim, Timmermans, Jean-Pierre, D'Hoore, André, Wouters, Pieter J, Van den Berghe, Greet

“…Insufficient autophagy resulting in inadequate clearance of cellular damage could explain lack of recovery from organ failure in the prolonged critically ill…”
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Altered cholesterol homeostasis in critical illness-induced muscle weakness: effect of exogenous 3-hydroxybutyrate by Goossens, ChloÃ, Weckx, Ruben, Derde, Sarah, Vander Perre, Sarah, Derese, Inge, Van Veldhoven, Paul P, Ghesquière, Bart, Van den Berghe, Greet, Langouche, Lies

“…Abstract Background Muscle weakness is a complication of critical illness which hampers recovery. In critically ill mice, supplementation with the ketone body…”
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Early Parenteral Nutrition Evokes a Phenotype of Autophagy Deficiency in Liver and Skeletal Muscle of Critically Ill Rabbits by Derde, Sarah, Vanhorebeek, Ilse, Güiza, Fabian, Derese, Inge, Gunst, Jan, Fahrenkrog, Birthe, Martinet, Wim, Vervenne, Hilke, Ververs, Eric-Jan, Larsson, Lars, Van den Berghe, Greet

“…Muscular and hepatic abnormalities observed in artificially fed critically ill patients strikingly resemble the phenotype of autophagy-deficient mice…”
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Role of Glucagon in Catabolism and Muscle Wasting of Critical Illness and Modulation by Nutrition by Thiessen, Steven E, Derde, Sarah, Derese, Inge, Dufour, Thomas, Vega, Chloé Albert, Langouche, Lies, Goossens, Chloë, Peersman, Nele, Vermeersch, Pieter, Vander Perre, Sarah, Holst, Jens J, Wouters, Pieter J, Vanhorebeek, Ilse, Van den Berghe, Greet

“…Critical illness is hallmarked by muscle wasting and disturbances in glucose, lipid, and amino acid homeostasis. Circulating concentrations of glucagon, a…”
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Obesity attenuates inflammation, protein catabolism, dyslipidaemia, and muscle weakness during sepsis, independent of leptin by Vankrunkelsven, Wouter, Derde, Sarah, Gunst, Jan, Vander Perre, Sarah, Declerck, Emiel, Pauwels, Lies, Derese, Inge, Van den Berghe, Greet, Langouche, Lies

“…Background Muscle weakness is a frequently occurring complication of sepsis, associated with increased morbidity and mortality. Interestingly, obesity…”
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The Role of Autophagy in Critical Illness-induced Liver Damage by Thiessen, Steven E., Derese, Inge, Derde, Sarah, Dufour, Thomas, Pauwels, Lies, Bekhuis, Youri, Pintelon, Isabel, Martinet, Wim, Van den Berghe, Greet, Vanhorebeek, Ilse

“…Mitochondrial dysfunction and endoplasmic reticulum (ER) stress, which activates the unfolded protein response (UPR), mediate critical illness-induced organ…”
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Development of muscle weakness in a mouse model of critical illness: does fibroblast growth factor 21 play a role? by Vankrunkelsven, Wouter, Thiessen, Steven, Derde, Sarah, Vervoort, Ellen, Derese, Inge, Pintelon, Isabel, Matheussen, Hanne, Jans, Alexander, Goossens, Chloë, Langouche, Lies, Van den Berghe, Greet, Vanhorebeek, Ilse

“…Critical illness is hallmarked by severe stress and organ damage. Fibroblast growth factor 21 (FGF21) has been shown to rise during critical illness. FGF21 is…”
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Impact of prolonged sepsis on neural and muscular components of muscle contractions in a mouse model by Goossens, Chloë, Weckx, Ruben, Derde, Sarah, Van Helleputte, Lawrence, Schneidereit, Dominik, Haug, Michael, Reischl, Barbara, Friedrich, Oliver, Van Den Bosch, Ludo, Van den Berghe, Greet, Langouche, Lies

“…Background Prolonged critically ill patients frequently develop debilitating muscle weakness that can affect both peripheral nerves and skeletal muscle…”
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Identification of the toxic threshold of 3-hydroxybutyrate-sodium supplementation in septic mice by Weckx, Ruben, Goossens, Chloë, Derde, Sarah, Pauwels, Lies, Vander Perre, Sarah, Van den Bergh, Greet, Langouche, Lies

“…In septic mice, supplementing parenteral nutrition with 150 mg/day 3-hydroxybutyrate-sodium-salt (3HB-Na) has previously shown to prevent muscle weakness…”
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Neuropathological Correlates of Hyperglycemia During Prolonged Polymicrobial Sepsis in Mice by Sonneville, Romain, Derese, Inge, Marques, Mirna Bastos, Langouche, Lies, Derde, Sarah, Chatre, Laurent, Chrétien, Fabrice, Annane, Djillali, Sharshar, Tarek, Van den Berghe, Greet, Vanhorebeek, Ilse

“…ABSTRACTGlucose toxicity may play a crucial role in evoking neurologic complications of critical illness. We studied whether the neuropathological alterations…”
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Glucocorticoid treatment increases cholesterol availability during critical illness: effect on adrenal and muscle function by De Bruyn, Lauren, Téblick, Arno, Van Oudenhove, Tim, Vander Perre, Sarah, Derese, Inge, Pauwels, Lies, Derde, Sarah, De Vlieger, Greet, Van den Berghe, Greet, Langouche, Lies

“…Hypocholesterolemia hallmarks critical illness though the underlying pathophysiology is incompletely understood. As low circulating cholesterol levels could…”
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Muscle atrophy and preferential loss of myosin in prolonged critically ill patients by DERDE, Sarah, HERMANS, Greet, VANHOREBEEK, Ilse, DERESE, Inge, GUIZA, Fabian, HEDSTROM, Yvette, WOUTERS, Pieter J, BRUYNINCKX, Frans, D'HOORE, André, LARSSON, Lars, VAN DEN BERGHE, Greet

“…Muscle weakness contributes to prolonged rehabilitation and adverse outcome of critically ill patients. Distinction between a neurogenic and/or myogenic…”
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Impact of Hydrocortisone and of CRH Infusion on the Hypothalamus-Pituitary-Adrenocortical Axis of Septic Male Mice by Téblick, Arno, De Bruyn, Lauren, Van Oudenhove, Tim, Vander Perre, Sarah, Pauwels, Lies, Derde, Sarah, Langouche, Lies, Van den Berghe, Greet

“…Purpose Sepsis is hallmarked by high plasma cortisol/corticosterone (CORT), low adrenocorticotropic hormone (ACTH), and high pro-opiomelanocortin (POMC). While…”
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Early neuromuscular electrical stimulation reduces the loss of muscle mass in critically ill patients – A within subject randomized controlled trial by Segers, Johan, Vanhorebeek, Ilse, Langer, Daniel, Charususin, Noppawan, Wei, Weili, Frickx, Bregje, Demeyere, Inge, Clerckx, Beatrix, Casaer, Michael, Derese, Inge, Derde, Sarah, Pauwels, Lies, Van den Berghe, Greet, Hermans, Greet, Gosselink, Rik

“…To investigate the effect of Neuromuscular Electrical Stimulation (NMES) on muscle thickness, strength and morphological and molecular markers of the…”
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The Hepatic Glucocorticoid Receptor Is Crucial for Cortisol Homeostasis and Sepsis Survival in Humans and Male Mice by Jenniskens, Marc, Weckx, Ruben, Dufour, Thomas, Vander Perre, Sarah, Pauwels, Lies, Derde, Sarah, Téblick, Arno, Güiza, Fabian, Van den Berghe, Greet, Langouche, Lies

“…Sepsis is hallmarked by hypercortisolemia, a stress response essential for survival. This elevation in plasma cortisol is partially brought about by suppressed…”
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On the Role of Illness Duration and Nutrient Restriction in Cholestatic Alterations that Occur During Critical Illness by Jenniskens, Marc, Güiza, Fabian, Oorts, Marlies, Vander Perre, Sarah, Derde, Sarah, Dufour, Thomas, Thiessen, Steven, Annaert, Pieter, Van den Berghe, Greet, Langouche, Lies

“…BACKGROUND AND AIMS:Elevated markers of cholestasis are common in response to critical illness, and associated with adverse outcome. The role of illness…”
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