Search Results - "Dera, Ayed A."

Synthesis, In Vitro Biological Evaluation and In Silico Molecular Docking Studies of Indole Based Thiadiazole Derivatives as Dual Inhibitor of Acetylcholinesterase and Butyrylchloinesterase by Khan, Shoaib, Iqbal, Shahid, Taha, Muhammad, Rahim, Fazal, Shah, Mazloom, Ullah, Hayat, Bahadur, Ali, Alrbyawi, Hamad, Dera, Ayed A, Alahmdi, Mohammed Issa, Pashameah, Rami Adel, Alzahrani, Eman, Farouk, Abd-ElAziem

“…The current study was conducted to obtain hybrid analogues of indole-based thiadiazole derivatives (1–16) in which a number of reaction steps were involved. To…”
Get full text

Thymoquinone inhibits IL‐7‐induced tumor progression and metastatic invasion in prostate cancer cells by attenuating matrix metalloproteinase activity and Akt/NF‐κB signaling by Alshyarba, Mishari, Otifi, Hassan, Al Fayi, Majed, A Dera, Ayed, Rajagopalan, Prasanna

“…Interleukin (IL)‐7 acts via the IL‐7 receptor in metastatic tumor progression in prostate cancer (PC). The current study aimed to evaluate thymoquinone (Tq),…”
Get full text

Identification of Potential Inhibitors for the Treatment of Alkaptonuria Using an Integrated In Silico Computational Strategy by Zaib, Sumera, Rana, Nehal, Hussain, Nadia, Ogaly, Hanan A, Dera, Ayed A, Khan, Imtiaz

“…Alkaptonuria (AKU) is a rare genetic autosomal recessive disorder characterized by elevated serum levels of homogentisic acid (HGA). In this disease, tyrosine…”
Get full text

Design, Synthesis, In Silico Testing, and In Vitro Evaluation of Thiazolidinone-Based Benzothiazole Derivatives as Inhibitors of α-Amylase and α-Glucosidase by Khan, Shoaib, Iqbal, Shahid, Khan, Marwa, Rehman, Wajid, Shah, Mazloom, Hussain, Rafaqat, Rasheed, Liaqat, Khan, Yousaf, Dera, Ayed A, Pashameah, Rami Adel, Alzahrani, Eman, Farouk, Abd-ElAziem

“…In this study, a stepwise reaction afforded thiazolidinone-based benzothiazole derivatives 1–15, and the synthesized derivatives were then screened for…”
Get full text

Identification of Potent Inhibitors Targeting EGFR and HER3 for Effective Treatment of Chemoresistance in Non-Small Cell Lung Cancer by Dera, Ayed A, Zaib, Sumera, Areeba, Hussain, Nadia, Rana, Nehal, Javed, Hira, Khan, Imtiaz

“…Non-small cell lung cancer (NSCLC) is the most common form of lung cancer. Despite the existence of various therapeutic options, NSCLC is still a major health…”
Get full text

Synthesis, In Vitro Anti-Microbial Analysis and Molecular Docking Study of Aliphatic Hydrazide-Based Benzene Sulphonamide Derivatives as Potent Inhibitors of α-Glucosidase and Urease by Khan, Shoaib, Iqbal, Shahid, Shah, Mazloom, Rehman, Wajid, Hussain, Rafaqat, Rasheed, Liaqat, Alrbyawi, Hamad, Dera, Ayed A, Alahmdi, Mohammed Issa, Pashameah, Rami Adel, Alzahrani, Eman, Farouk, Abd-ElAziem

“…A unique series of sulphonamide derivatives was attempted to be synthesized in this study using a new and effective method. All of the synthesized compounds…”
Get full text

Synthesis of Novel Benzimidazole-Based Thiazole Derivatives as Multipotent Inhibitors of α-Amylase and α-Glucosidase: In Vitro Evaluation along with Molecular Docking Study by Hussain, Rafaqat, Iqbal, Shahid, Shah, Mazloom, Rehman, Wajid, Khan, Shoaib, Rasheed, Liaqat, Rahim, Fazal, Dera, Ayed A, Kehili, Sana, Elkaeed, Eslam B, Awwad, Nasser S, Bajaber, Majed A, Alahmdi, Mohammed Issa, Alrbyawi, Hamad, Alsaab, Hashem O

“…In this study, hybrid analogs of benzimidazole containing a thiazole moiety (1–17) were afforded and then tested for their ability to inhibit α-amylase and…”
Get full text

Bioinformatics approach for the construction of multiple epitope vaccine against omicron variant of SARS-CoV-2 by Zaib, Sumera, Akram, Fatima, Liaqat, Syed Talha, Altaf, Muhammad Zain, Khan, Imtiaz, Dera, Ayed A., Uddin, Jalal, Khan, Ajmal, Al-Harrasi, Ahmed

“…The World Health Organization categorized SARS-CoV-2 as a variant of concern, having numerous mutations in spike protein, which have been found to evade the…”
Get full text

Antioxidant and Gastroprotective Activity of Suaeda fruticosa Forssk. Ex J.F.Gmel by Ayaz, Afsheen, Jamil, QurratUlAin, Hussain, Musaddique, Anjum, Fayyaz, Sarfraz, Adeel, Alqahtani, Taha, Hussain, Nadia, Gahtani, Reem M., Dera, Ayed A., Alharbi, Hanan M., Iqbal, Shahid M.

“…Suaeda fruticosa Forssk. Ex J.F.Gmel is traditionally used for inflammatory and digestive disorders, as a carminative, and for diarrhea. This plant is widely…”
Get full text

New Triazinoindole Bearing Benzimidazole/Benzoxazole Hybrids Analogs as Potent Inhibitors of Urease: Synthesis, In Vitro Analysis and Molecular Docking Studies by Mumtaz, Sundas, Iqbal, Shahid, Shah, Mazloom, Hussain, Rafaqat, Rahim, Fazal, Rehman, Wajid, Khan, Shoaib, Abid, Obaid-Ur-Rahman, Rasheed, Liaqat, Dera, Ayed A, Al-Ghulikah, Hanan A, Kehili, Sana, Elkaeed, Eslam B, Alrbyawi, Hamad, Alahmdi, Mohammed Issa

“…Twenty-four analogs based on triazinoindole bearing benzimidazole/benzoxazole moieties ( - ) were synthesized. Utilizing a variety of spectroscopic methods,…”
Get full text

Ultrasound-Assisted Synthesis of Piperidinyl-Quinoline Acylhydrazones as New Anti-Alzheimer's Agents: Assessment of Cholinesterase Inhibitory Profile, Molecular Docking Analysis, and Drug-like Properties by Munir, Rubina, Zaib, Sumera, Zia-Ur-Rehman, Muhammad, Hussain, Nadia, Chaudhry, Faryal, Younas, Muhammad Tayyab, Zahra, Fatima Tuz, Tajammul, Zainab, Javid, Noman, Dera, Ayed A, Ogaly, Hanan A, Khan, Imtiaz

“…Alzheimer's disease (AD) is one of the progressive neurological disorders and the main cause of dementia all over the world. The multifactorial nature of…”
Get full text

Fabrication of Cr-ZnFe2O4/S-g-C3N4 Heterojunction Enriched Charge Separation for Sunlight Responsive Photocatalytic Performance and Antibacterial Study by Zhang, Ping, Munawar, Tehreem, Soltane, Raya, Javed, Mohsin, Liu, Guocong, Iqbal, Shahid, Qamar, Muhammad Azam, Dera, Ayed A., Alrbyawi, Hamad, Alfakeer, M., Rabea, Sameh, Elkaeed, Eslam B.

“…There has been a lot of interest in the manufacture of stable, high-efficiency photocatalysts. In this study, initially Cr doped ZnFe2O4 nanoparticles (NPs)…”
Get full text

Bone morphogenetic protein (BMP)9 in cancer development: mechanistic, diagnostic, and therapeutic approaches? by Alkhathami, Ali G., Abdullah, Mustafa Ryadh, Ahmed, Muhjaha, Hassan Ahmed, Hanan, Alwash, Sarab W., Muhammed Mahdi, Zahra, Alsaikhan, Fahad, Dera, Ayed A.

“…Bone morphogenetic protein (BMP)-9 is considered a member of the transforming growth factor (TGF)β superfamily. It was first found as an inducer of bone and…”
Get full text

Designing multi-epitope monkeypox virus-specific vaccine using immunoinformatics approach by Zaib, Sumera, Rana, Nehal, Areeba, Hussain, Nadia, Alrbyawi, Hamad, Dera, Ayed A., Khan, Imtiaz, Khalid, Mohammad, Khan, Ajmal, Al-Harrasi, Ahmed

“…Monkeypox virus is an enveloped DNA virus that belongs to Poxviridae family. The virus is transmitted from rodents to primates via infected body fluids, skin…”
Get full text

Simultaneous Quantification of Opioids in Blood and Urine by Gas Chromatography-Mass Spectrometer with Modified Dispersive Solid-Phase Extraction Technique by Yasien, Sara, Ali, Ejaz, Javed, Mohsin, Iqbal, Muhammad Muntazir, Iqbal, Shahid, Alrbyawi, Hamad, Aljazzar, Samar O, Elkaeed, Eslam B, Dera, Ayed A, Pashameah, Rami Adel, Alzahrani, Eman, Farouk, Abd-ElAziem

“…Common methodologies such as liquid-liquid extraction and solid-phase extraction are applied for the extraction of opioids from biological specimens i.e.,…”
Get full text

New Biologically Hybrid Pharmacophore Thiazolidinone-Based Indole Derivatives: Synthesis, In Vitro Αlpha-Amylase and Αlpha-Glucosidase Along with Molecular Docking Investigations by Khan, Shoaib, Iqbal, Shahid, Rahim, Fazal, Shah, Mazloom, Hussain, Rafaqat, Alrbyawi, Hamad, Rehman, Wajid, Dera, Ayed A, Rasheed, Liaqat, Somaily, H H, Pashameah, Rami Adel, Alzahrani, Eman, Farouk, Abd-ElAziem

“…Amylase and glucosidase enzymes are the primary harmful source in the development of the chronic condition known as diabetes mellitus. The main function of…”
Get full text

Computational docking and in vitro analysis identifies novel arylidene analogue FPMXY-14 against renal cancer cells by attenuating Akt by Otifi, Hassan M, Alshyarba, Mishari, Fayi, Majed Al, Dera, Ayed A, Rajagopalan, Prasanna

“…Targeted therapies are gaining global attention to tackle Renal Cancer (RC). This study aims to screen FPMXY-14 (novel arylidene analogue) for Akt inhibition…”
Get full text

Antibacterial and anti-biofilm activity of plumbagin against multi-drug resistant clinical bacterial isolates by Alfhili, Mohammad A, Ahmad, Irfan, Alraey, Yasser, Alangari, Abdulaziz, Alqahtani, Taha, Dera, Ayed A

“…To evaluate the antibacterial activity of plumbagin (PGN) against multidrug resistance (MDR) clinical isolates. This study was carried out at the Department of…”
Get full text

Evaluation of antibacterial properties of Matricaria aurea on clinical isolates of periodontitis patients with special reference to red complex bacteria by Ahmad, Irfan, Wahab, Shadma, Nisar, Nazima, Dera, Ayed A., Alshahrani, Mohammad Y, Abullias, Shahabe Saquib, Irfan, Safia, Alam, Mohammad Mahtab, Srivastava, Saurabh

“…Chronic periodontitis has an interplay between different species of bacteria found in dental biofilms act a crucial role in pathogenesis and disease…”
Get full text

Synthesis, in vitro biological assessment, and molecular docking study of benzimidazole-based thiadiazole derivatives as dual inhibitors of α-amylase and α-glucosidase by Khan, Shoaib, Iqbal, Shahid, Taha, Muhammad, Hussain, Rafaqat, Rahim, Fazal, Shah, Mazloom, Awwad, Nasser S, Ibrahium, Hala A, Alahmdi, Mohammed Issa, Dera, Ayed A, Ullah, Hayat, Bahadur, Ali, Aljazzar, Samar O, Elkaeed, Eslam B, Rauf, Muhammad

“…The clinical significance of benzimidazole-containing drugs has increased in the current study, making them more effective scaffolds. These moieties have…”
Get full text