Search Results - "Dera, Ayed"

Thymoquinone and curcumin combination protects cisplatin-induced kidney injury, nephrotoxicity by attenuating NFκB, KIM-1 and ameliorating Nrf2/HO-1 signalling by Al Fayi, Majed, Otifi, Hassan, Alshyarba, Mishari, Dera, Ayed A, Rajagopalan, Prasanna

“…This study evaluates the protective effects of Thymoquinone (Tq) and Curcumin (Cur) in models of cisplatin-induced renal toxicity. Proliferation studies were…”
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Thymoquinone inhibits IL‐7‐induced tumor progression and metastatic invasion in prostate cancer cells by attenuating matrix metalloproteinase activity and Akt/NF‐κB signaling by Alshyarba, Mishari, Otifi, Hassan, Al Fayi, Majed, A Dera, Ayed, Rajagopalan, Prasanna

“…Interleukin (IL)‐7 acts via the IL‐7 receptor in metastatic tumor progression in prostate cancer (PC). The current study aimed to evaluate thymoquinone (Tq),…”
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Recent developments in natural biopolymer based drug delivery systems by Fazal, Tanzeela, Murtaza, Bibi Nazia, Shah, Mazloom, Iqbal, Shahid, Rehman, Mujaddad-ur, Jaber, Fadi, Dera, Ayed A, Awwad, Nasser S, Ibrahium, Hala A

“…Targeted delivery of drug molecules to diseased sites is a great challenge in pharmaceutical and biomedical sciences. Fabrication of drug delivery systems…”
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Synthesis, In Vitro Biological Evaluation and In Silico Molecular Docking Studies of Indole Based Thiadiazole Derivatives as Dual Inhibitor of Acetylcholinesterase and Butyrylchloinesterase by Khan, Shoaib, Iqbal, Shahid, Taha, Muhammad, Rahim, Fazal, Shah, Mazloom, Ullah, Hayat, Bahadur, Ali, Alrbyawi, Hamad, Dera, Ayed A, Alahmdi, Mohammed Issa, Pashameah, Rami Adel, Alzahrani, Eman, Farouk, Abd-ElAziem

“…The current study was conducted to obtain hybrid analogues of indole-based thiadiazole derivatives (1–16) in which a number of reaction steps were involved. To…”
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Identification of Potential Inhibitors for the Treatment of Alkaptonuria Using an Integrated In Silico Computational Strategy by Zaib, Sumera, Rana, Nehal, Hussain, Nadia, Ogaly, Hanan A, Dera, Ayed A, Khan, Imtiaz

“…Alkaptonuria (AKU) is a rare genetic autosomal recessive disorder characterized by elevated serum levels of homogentisic acid (HGA). In this disease, tyrosine…”
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Design, Synthesis, In Silico Testing, and In Vitro Evaluation of Thiazolidinone-Based Benzothiazole Derivatives as Inhibitors of α-Amylase and α-Glucosidase by Khan, Shoaib, Iqbal, Shahid, Khan, Marwa, Rehman, Wajid, Shah, Mazloom, Hussain, Rafaqat, Rasheed, Liaqat, Khan, Yousaf, Dera, Ayed A, Pashameah, Rami Adel, Alzahrani, Eman, Farouk, Abd-ElAziem

“…In this study, a stepwise reaction afforded thiazolidinone-based benzothiazole derivatives 1–15, and the synthesized derivatives were then screened for…”
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Identification of Potent Inhibitors Targeting EGFR and HER3 for Effective Treatment of Chemoresistance in Non-Small Cell Lung Cancer by Dera, Ayed A, Zaib, Sumera, Areeba, Hussain, Nadia, Rana, Nehal, Javed, Hira, Khan, Imtiaz

“…Non-small cell lung cancer (NSCLC) is the most common form of lung cancer. Despite the existence of various therapeutic options, NSCLC is still a major health…”
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Synthesis, In Vitro Anti-Microbial Analysis and Molecular Docking Study of Aliphatic Hydrazide-Based Benzene Sulphonamide Derivatives as Potent Inhibitors of α-Glucosidase and Urease by Khan, Shoaib, Iqbal, Shahid, Shah, Mazloom, Rehman, Wajid, Hussain, Rafaqat, Rasheed, Liaqat, Alrbyawi, Hamad, Dera, Ayed A, Alahmdi, Mohammed Issa, Pashameah, Rami Adel, Alzahrani, Eman, Farouk, Abd-ElAziem

“…A unique series of sulphonamide derivatives was attempted to be synthesized in this study using a new and effective method. All of the synthesized compounds…”
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Synthesis of Novel Benzimidazole-Based Thiazole Derivatives as Multipotent Inhibitors of α-Amylase and α-Glucosidase: In Vitro Evaluation along with Molecular Docking Study by Hussain, Rafaqat, Iqbal, Shahid, Shah, Mazloom, Rehman, Wajid, Khan, Shoaib, Rasheed, Liaqat, Rahim, Fazal, Dera, Ayed A, Kehili, Sana, Elkaeed, Eslam B, Awwad, Nasser S, Bajaber, Majed A, Alahmdi, Mohammed Issa, Alrbyawi, Hamad, Alsaab, Hashem O

“…In this study, hybrid analogs of benzimidazole containing a thiazole moiety (1–17) were afforded and then tested for their ability to inhibit α-amylase and…”
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Bioinformatics approach for the construction of multiple epitope vaccine against omicron variant of SARS-CoV-2 by Zaib, Sumera, Akram, Fatima, Liaqat, Syed Talha, Altaf, Muhammad Zain, Khan, Imtiaz, Dera, Ayed A., Uddin, Jalal, Khan, Ajmal, Al-Harrasi, Ahmed

“…The World Health Organization categorized SARS-CoV-2 as a variant of concern, having numerous mutations in spike protein, which have been found to evade the…”
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Circulating microRNAs as potential diagnostic biomarkers for osteoporosis by Mandourah, Abdullah Y., Ranganath, Lakshminarayan, Barraclough, Roger, Vinjamuri, Sobhan, Hof, Robert Van’T, Hamill, Sandra, Czanner, Gabriela, Dera, Ayed A., Wang, Duolao, Barraclough, Dong L.

“…Osteoporosis is the most common age-related bone disease worldwide and is usually clinically asymptomatic until the first fracture happens. MicroRNAs are…”
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Bone morphogenetic protein (BMP)9 in cancer development: mechanistic, diagnostic, and therapeutic approaches? by Alkhathami, Ali G., Abdullah, Mustafa Ryadh, Ahmed, Muhjaha, Hassan Ahmed, Hanan, Alwash, Sarab W., Muhammed Mahdi, Zahra, Alsaikhan, Fahad, Dera, Ayed A.

“…Bone morphogenetic protein (BMP)-9 is considered a member of the transforming growth factor (TGF)β superfamily. It was first found as an inducer of bone and…”
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Indirubin-3-monoxime and thymoquinone exhibit synergistic efficacy as therapeutic combination in in-vitro and in-vivo models of Lung cancer by Dera, Ayed A., Rajagopalan, Prasanna, Al Fayi, Majed, Ahmed, Irfan, Chandramoorthy, Harish C.

“…In this study, we report the combination of indirubin-3-monoxime (I3M) and thymoquinone (Tq) to have excellent therapeutic efficacy in models of Lung cancer…”
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Thymoquinone attenuates oxidative stress of kidney mitochondria and exerts nephroprotective effects in oxonic acid‐induced hyperuricemia rats by Dera, Ayed A., Rajagopalan, Prasanna, Alfhili, Mohammad A., Ahmed, Irfan, Chandramoorthy, Harish C

“…Background Recent studies indicate hyperuricemia as an aggravating factor for kidney diseases progression. Basic research for novel agents to reduce…”
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Antioxidant and Gastroprotective Activity of Suaeda fruticosa Forssk. Ex J.F.Gmel by Ayaz, Afsheen, Jamil, QurratUlAin, Hussain, Musaddique, Anjum, Fayyaz, Sarfraz, Adeel, Alqahtani, Taha, Hussain, Nadia, Gahtani, Reem M., Dera, Ayed A., Alharbi, Hanan M., Iqbal, Shahid M.

“…Suaeda fruticosa Forssk. Ex J.F.Gmel is traditionally used for inflammatory and digestive disorders, as a carminative, and for diarrhea. This plant is widely…”
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New Triazinoindole Bearing Benzimidazole/Benzoxazole Hybrids Analogs as Potent Inhibitors of Urease: Synthesis, In Vitro Analysis and Molecular Docking Studies by Mumtaz, Sundas, Iqbal, Shahid, Shah, Mazloom, Hussain, Rafaqat, Rahim, Fazal, Rehman, Wajid, Khan, Shoaib, Abid, Obaid-Ur-Rahman, Rasheed, Liaqat, Dera, Ayed A, Al-Ghulikah, Hanan A, Kehili, Sana, Elkaeed, Eslam B, Alrbyawi, Hamad, Alahmdi, Mohammed Issa

“…Twenty-four analogs based on triazinoindole bearing benzimidazole/benzoxazole moieties ( - ) were synthesized. Utilizing a variety of spectroscopic methods,…”
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Computational docking and in vitro analysis identifies novel arylidene analogue FPMXY-14 against renal cancer cells by attenuating Akt by Otifi, Hassan M, Alshyarba, Mishari, Fayi, Majed Al, Dera, Ayed A, Rajagopalan, Prasanna

“…Targeted therapies are gaining global attention to tackle Renal Cancer (RC). This study aims to screen FPMXY-14 (novel arylidene analogue) for Akt inhibition…”
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Ultrasound-Assisted Synthesis of Piperidinyl-Quinoline Acylhydrazones as New Anti-Alzheimer's Agents: Assessment of Cholinesterase Inhibitory Profile, Molecular Docking Analysis, and Drug-like Properties by Munir, Rubina, Zaib, Sumera, Zia-Ur-Rehman, Muhammad, Hussain, Nadia, Chaudhry, Faryal, Younas, Muhammad Tayyab, Zahra, Fatima Tuz, Tajammul, Zainab, Javid, Noman, Dera, Ayed A, Ogaly, Hanan A, Khan, Imtiaz

“…Alzheimer's disease (AD) is one of the progressive neurological disorders and the main cause of dementia all over the world. The multifactorial nature of…”
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Fabrication of Cr-ZnFe2O4/S-g-C3N4 Heterojunction Enriched Charge Separation for Sunlight Responsive Photocatalytic Performance and Antibacterial Study by Zhang, Ping, Munawar, Tehreem, Soltane, Raya, Javed, Mohsin, Liu, Guocong, Iqbal, Shahid, Qamar, Muhammad Azam, Dera, Ayed A., Alrbyawi, Hamad, Alfakeer, M., Rabea, Sameh, Elkaeed, Eslam B.

“…There has been a lot of interest in the manufacture of stable, high-efficiency photocatalysts. In this study, initially Cr doped ZnFe2O4 nanoparticles (NPs)…”
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Designing multi-epitope monkeypox virus-specific vaccine using immunoinformatics approach by Zaib, Sumera, Rana, Nehal, Areeba, Hussain, Nadia, Alrbyawi, Hamad, Dera, Ayed A., Khan, Imtiaz, Khalid, Mohammad, Khan, Ajmal, Al-Harrasi, Ahmed

“…Monkeypox virus is an enveloped DNA virus that belongs to Poxviridae family. The virus is transmitted from rodents to primates via infected body fluids, skin…”
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