Search Results - "DerMardirossian, Celine"

Phosphorylation of RhoGDI by Src regulates Rho GTPase binding and cytosol-membrane cycling by DerMardirossian, Céline, Rocklin, Gabriel, Seo, Ji-Yeon, Bokoch, Gary M

“…Rho GTPases (Rac, Rho, and Cdc42) play important roles in regulating cell function through their ability to coordinate the actin cytoskeleton, modulate the…”
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Pak1 regulates focal adhesion strength, myosin IIA distribution, and actin dynamics to optimize cell migration by Delorme-Walker, Violaine D, Peterson, Jeffrey R, Chernoff, Jonathan, Waterman, Clare M, Danuser, Gaudenz, DerMardirossian, Céline, Bokoch, Gary M

“…Cell motility requires the spatial and temporal coordination of forces in the actomyosin cytoskeleton with extracellular adhesion. The biochemical mechanism…”
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A Novel and Specific NADPH Oxidase-1 (Nox1) Small-Molecule Inhibitor Blocks the Formation of Functional Invadopodia in Human Colon Cancer Cells by Gianni, Davide, Taulet, Nicolas, Zhang, Hui, DerMardirossian, Celine, Kister, Jeremy, Martinez, Luis, Roush, William R, Brown, Steven J, Bokoch, Gary M, Rosen, Hugh

“…The NADPH oxidase (Nox) proteins catalyze the regulated formation of reactive oxygen species (ROS), which play key roles as signaling molecules in several…”
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GEF-H1: Orchestrating the interplay between cytoskeleton and vesicle trafficking by Pathak, Ritu, DerMardirossian, Celine

“…Vesicle trafficking is crucial for delivery of membrane compartments as well as signaling molecules to specific sites on the plasma membrane for regulation of…”
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Kinome-wide Functional Analysis Highlights the Role of Cytoskeletal Remodeling in Somatic Cell Reprogramming by Sakurai, Kumi, Talukdar, Indrani, Patil, Veena S., Dang, Jason, Li, Zhonghan, Chang, Kung-Yen, Lu, Chih-Chung, Delorme-Walker, Violaine, DerMardirossian, Celine, Anderson, Karen, Hanein, Dorit, Yang, Chao-Shun, Wu, Dongmei, Liu, Yang, Rana, Tariq M.

“…The creation of induced pluripotent stem cells (iPSCs) from somatic cells by ectopic expression of transcription factors has galvanized the fields of…”
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Regulation of hypoxic neuronal death signaling by neuroglobin by Khan, Adil A, Mao, Xiao Ou, Banwait, Surita, DerMardirossian, Celine M, Bokoch, Gary M, Jin, Kunlin, Greenberg, David A

“…The signal transduction pathways involved in neuronal death are not well understood. Neuroglobin (Ngb), a recently discovered vertebrate globin expressed…”
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Caveolin-1 Phosphorylation Is Essential for Axonal Growth of Human Neurons Derived From iPSCs by Wang, Shanshan, Zhang, Zheng, Almenar-Queralt, Angels, Leem, Joseph, DerMardirossian, Celine, Roth, David M, Patel, Piyush M, Patel, Hemal H, Head, Brian P

“…Proper axonal growth and guidance is essential for neuron differentiation and development. Abnormal neuronal development due to genetic or epigenetic…”
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p21-activated Kinase 1 Phosphorylates and Regulates 14-3-3 Binding to GEF-H1, a Microtubule-localized Rho Exchange Factor by Zenke, Frank T, Krendel, Mira, DerMardirossian, Celine, King, Charles C, Bohl, Benjamin P, Bokoch, Gary M

“…GEF-H1 is a guanine nucleotide exchange factor for Rho whose activity is regulated through a cycle of microtubule binding and release. Here we identify a…”
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A novel Rac1 GAP splice variant relays poly-Ub accumulation signals to mediate Rac1 inactivation by Huang, Timothy Y, Michael, Sarah, Xu, Tao, Sarkeshik, Ali, Moresco, James J, Yates, 3rd, John R, Masliah, Eliezer, Bokoch, Gary M, DerMardirossian, Céline

“…Spatial control of RhoGTPase-inactivating GAP components remains largely enigmatic. We describe a brain-specific RhoGAP splice variant, BARGIN (BGIN), which…”
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c-Src-mediated phosphorylation of NoxA1 and Tks4 induces the reactive oxygen species (ROS)-dependent formation of functional invadopodia in human colon cancer cells by Gianni, Davide, Taulet, Nicolas, DerMardirossian, Céline, Bokoch, Gary M

“…The NADPH oxidase family, consisting of Nox1-5 and Duox1-2, catalyzes the regulated formation of reactive oxygen species (ROS). Highly expressed in the colon,…”
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Reactive oxygen species regulate protrusion efficiency by controlling actin dynamics by Taulet, Nicolas, Delorme-Walker, Violaine D, DerMardirossian, Céline

“…Productive protrusions allowing motile cells to sense and migrate toward a chemotactic gradient of reactive oxygen species (ROS) require a tight control of the…”
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FRET binding antenna reports spatiotemporal dynamics of GDI–Cdc42 GTPase interactions by Hodgson, Louis, Spiering, Désirée, Sabouri-Ghomi, Mohsen, Dagliyan, Onur, DerMardirossian, Céline, Danuser, Gaudenz, Hahn, Klaus M

“…The modification of Cdc42 with a FRET binding antenna (GDI.Cdc42 FLARE) enables detection of Cdc42 binding to guanine-nucleotide dissociation inhibitor (GDI)…”
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Cofilin Activity Downstream of Pak1 Regulates Cell Protrusion Efficiency by Organizing Lamellipodium and Lamella Actin Networks by Delorme, Violaine, Machacek, Matthias, DerMardirossian, Céline, Anderson, Karen L., Wittmann, Torsten, Hanein, Dorit, Waterman-Storer, Clare, Danuser, Gaudenz, Bokoch, Gary M.

“…Protrusion of the leading edge of migrating epithelial cells requires precise regulation of two actin filament (F-actin) networks, the lamellipodium and the…”
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Chronophin coordinates cell leading edge dynamics by controlling active cofilin levels by Delorme-Walker, Violaine, Seo, Ji-Yeon, Gohla, Antje, Fowler, Bruce, Bohl, Ben, DerMardirossian, Céline

“…Cofilin, a critical player of actin dynamics, is spatially and temporally regulated to control the direction and force of membrane extension required for cell…”
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Direct interaction between Tks proteins and the N-terminal proline-rich region (PRR) of NoxA1 mediates Nox1-dependent ROS generation by Gianni, Davide, DerMardirossian, Céline, Bokoch, Gary M.

“…NADPH oxidase (Nox) family enzymes are one of the main sources of cellular reactive oxygen species (ROS), which have been implicated in several physiological…”
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Cofilin phosphatases and regulation of actin dynamics by Huang, Timothy Y, DerMardirossian, Céline, Bokoch, Gary M

“…Cofilin is a ubiquitous actin-binding factor required for the reorganization of actin filaments in eukaryotes. The dephosphorylation of cofilin enables its…”
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Phosphorylation of RhoGDI by Pak1 Mediates Dissociation of Rac GTPase by DerMardirossian, Céline, Schnelzer, Andreas, Bokoch, Gary M.

“…Selective activation of Rac GTPase signaling pathways requires the specific release of Rac from RhoGDI complexes. We identified a RhoGDI kinase from bovine…”
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Structure-activity relationships in flexible protein domains: regulation of rho GTPases by RhoGDI and D4 GDI by Golovanov, Alexander P., Chuang, Tsung-Hsien, DerMardirossian, Celine, Barsukov, Igor, Hawkins, Dawn, Badii, Ramin, Bokoch, Gary M., Lian, Lu-Yun, Roberts, Gordon C.K.

“…The guanine dissociation inhibitors RhoGDI and D4GDI inhibit guanosine 5′-diphosphate dissociation from Rho GTPases, keeping these small GTPases in an inactive…”
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The Microtubule-Associated Rho Activating Factor GEF-H1 Interacts with Exocyst Complex to Regulate Vesicle Traffic by Pathak, Ritu, Delorme-Walker, Violaine D., Howell, Michael C., Anselmo, Anthony N., White, Michael A., Bokoch, Gary M., DerMardirossian, Céline

“…The exocyst complex plays a critical role in targeting and tethering vesicles to specific sites of the plasma membrane. These events are crucial for polarized…”
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Phosphorylation of RhoGDI by p21-activated kinase 1 by DerMardirossian, Celine M, Bokoch, Gary M

“…Rho GTPase activation is partially regulated at the level of guanine nucleotide dissociation inhibitors, or GDIs. The binding of Rho GTPases to GDIs has been…”
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