Search Results - "Depaoli, Maria R."

Real-Time Imaging of Mitochondrial ATP Dynamics Reveals the Metabolic Setting of Single Cells by Depaoli, Maria R., Karsten, Felix, Madreiter-Sokolowski, Corina T., Klec, Christiane, Gottschalk, Benjamin, Bischof, Helmut, Eroglu, Emrah, Waldeck-Weiermair, Markus, Simmen, Thomas, Graier, Wolfgang F., Malli, Roland

“…Reprogramming of metabolic pathways determines cell functions and fate. In our work, we have used organelle-targeted ATP biosensors to evaluate cellular…”
Get full text

The enigmatic ATP supply of the endoplasmic reticulum by Depaoli, Maria R., Hay, Jesse C., Graier, Wolfgang F., Malli, Roland

“…ABSTRACT The endoplasmic reticulum (ER) is a functionally and morphologically complex cellular organelle largely responsible for a variety of crucial…”
Get full text

Live cell imaging of signaling and metabolic activities by Depaoli, Maria R., Bischof, Helmut, Eroglu, Emrah, Burgstaller, Sandra, Ramadani-Muja, Jeta, Rauter, Thomas, Schinagl, Maximilian, Waldeck-Weiermair, Markus, Hay, Jesse C., Graier, Wolfgang F., Malli, Roland

“…The interplay of metabolic and signaling processes is prerequisite for the functionality of cells. Any disturbances may have severe consequences, resulting in…”
Get full text

Fasting improves therapeutic response in hepatocellular carcinoma through p53-dependent metabolic synergism by Krstic, Jelena, Reinisch, Isabel, Schindlmaier, Katharina, Galhuber, Markus, Riahi, Zina, Berger, Natascha, Kupper, Nadja, Moyschewitz, Elisabeth, Auer, Martina, Michenthaler, Helene, Nössing, Christoph, Depaoli, Maria R, Ramadani-Muja, Jeta, Usluer, Sinem, Stryeck, Sarah, Pichler, Martin, Rinner, Beate, Deutsch, Alexander J A, Reinisch, Andreas, Madl, Tobias, Chiozzi, Riccardo Zenezini, Heck, Albert J R, Huch, Meritxell, Malli, Roland, Prokesch, Andreas

“…Cancer cells voraciously consume nutrients to support their growth, exposing metabolic vulnerabilities that can be therapeutically exploited. Here, we show in…”
Get full text

Development and Application of Sub-Mitochondrial Targeted Ca2 + Biosensors by Waldeck-Weiermair, Markus, Gottschalk, Benjamin, Madreiter-Sokolowski, Corina T., Ramadani-Muja, Jeta, Ziomek, Gabriela, Klec, Christiane, Burgstaller, Sandra, Bischof, Helmut, Depaoli, Maria R., Eroglu, Emrah, Malli, Roland, Graier, Wolfgang F.

“…Mitochondrial Ca2+ uptake into the mitochondrial matrix is a well-established mechanism. However, the sub-organellar Ca2+ kinetics remain elusive. In the…”
Get full text

Metabolic Profiling of Single Cancer Cells Using Mitochondrial ATP Probes by Rauter, Thomas, Depaoli, Maria R., Bischof, Helmut, Graier, Wolfgang F., Malli, Roland

“…The metabolic activity of cells is interrelated with cell signaling, functions, and fate. Uncontrolled cancer cell proliferation requires metabolic…”
Get full text

Genetic biosensors for imaging nitric oxide in single cells by Eroglu, Emrah, Charoensin, Suphachai, Bischof, Helmut, Ramadani, Jeta, Gottschalk, Benjamin, Depaoli, Maria R., Waldeck-Weiermair, Markus, Graier, Wolfgang F., Malli, Roland

“…Over the last decades a broad collection of sophisticated fluorescent protein-based probes was engineered with the aim to specifically monitor nitric oxide…”
Get full text

Intact mitochondrial Ca2+ uniport is essential for agonist-induced activation of endothelial nitric oxide synthase (eNOS) by Charoensin, Suphachai, Eroglu, Emrah, Opelt, Marissa, Bischof, Helmut, Madreiter-Sokolowski, Corina T., Kirsch, Andrijana, Depaoli, Maria R., Frank, Saša, Schrammel, Astrid, Mayer, Bernd, Waldeck-Weiermair, Markus, Graier, Wolfgang F., Malli, Roland

“…Mitochondrial Ca2+ uptake regulates diverse endothelial cell functions and has also been related to nitric oxide (NO•) production. However, it is not entirely…”
Get full text

Intact mitochondrial Ca 2+ uniport is essential for agonist-induced activation of endothelial nitric oxide synthase (eNOS) by Charoensin, Suphachai, Eroglu, Emrah, Opelt, Marissa, Bischof, Helmut, Madreiter-Sokolowski, Corina T, Kirsch, Andrijana, Depaoli, Maria R, Frank, Saša, Schrammel, Astrid, Mayer, Bernd, Waldeck-Weiermair, Markus, Graier, Wolfgang F, Malli, Roland

“…Mitochondrial Ca uptake regulates diverse endothelial cell functions and has also been related to nitric oxide (NO ) production. However, it is not entirely…”
Get full text

Presenilin-1 Established ER-Ca2+ Leak: a Follow Up on Its Importance for the Initial Insulin Secretion in Pancreatic Islets and β-Cells Upon Elevated Glucose by Klec, Christiane, Madreiter-Sokolowski, Corina T, Ziomek, Gabriela, Stryeck, Sarah, Sachdev, Vinay, Duta-Mare, Madalina, Gottschalk, Benjamin, Depaoli, Maria R, Rost, Rene, Hay, Jesse, Waldeck-Weiermair, Markus, Kratky, Dagmar, Madl, Tobias, Malli, Roland, Graier, Wolfgang F

“…BACKGROUND/AIMSIn our recent work, the importance of GSK3β-mediated phosphorylation of presenilin-1 as crucial process to establish a Ca2+ leak in the…”
Get full text

Glycogen Synthase Kinase 3 Beta Controls Presenilin-1-Mediated Endoplasmic Reticulum Ca²⁺ Leak Directed to Mitochondria in Pancreatic Islets and β-Cells by Klec, Christiane, Madreiter-Sokolowski, Corina T, Stryeck, Sarah, Sachdev, Vinay, Duta-Mare, Madalina, Gottschalk, Benjamin, Depaoli, Maria R, Rost, Rene, Hay, Jesse, Waldeck-Weiermair, Markus, Kratky, Dagmar, Madl, Tobias, Malli, Roland, Graier, Wolfgang F

“…In pancreatic β-cells, the intracellular Ca²⁺ homeostasis is an essential regulator of the cells major functions. The endoplasmic reticulum (ER) as interactive…”
Get full text

Application of Genetically Encoded Fluorescent Nitric Oxide (NO•) Probes, the geNOps, for Real-time Imaging of NO• Signals in Single Cells by Eroglu, Emrah, Rost, Rene, Bischof, Helmut, Blass, Sandra, Schreilechner, Anna, Gottschalk, Benjamin, Depaoli, Maria R, Klec, Christiane, Charoensin, Suphachai, Madreiter-Sokolowski, Corina T, Ramadani, Jeta, Waldeck-Weiermair, Markus, Graier, Wolfgang F, Malli, Roland

“…Nitric Oxide (NO•) is a small radical, which mediates multiple important cellular functions in mammals, bacteria and plants. Despite the existence of a large…”
Get full text

Real-time imaging of mitochondrial ATP dynamics discloses the metabolic setting of single cells by Depaoli, Maria R., Karsten, Felix, Madreiter-Sokolowski, Corina T., Klec, Christiane, Gottschalk, Benjamin, Bischof, Helmut, Eroglu, Emrah, Waldeck-Weiermair, Markus, Graier, Wolfgang F., Malli, Roland

Get full text

Development and Application of Sub-Mitochondrial Targeted Ca 2 + Biosensors by Waldeck-Weiermair, Markus, Gottschalk, Benjamin, Madreiter-Sokolowski, Corina T, Ramadani-Muja, Jeta, Ziomek, Gabriela, Klec, Christiane, Burgstaller, Sandra, Bischof, Helmut, Depaoli, Maria R, Eroglu, Emrah, Malli, Roland, Graier, Wolfgang F

“…Mitochondrial Ca uptake into the mitochondrial matrix is a well-established mechanism. However, the sub-organellar Ca kinetics remain elusive. In the present…”
Get full text

Application of Genetically Encoded Fluorescent Nitric Oxide (NO) Probes, the geNOps, for Real-time Imaging of NO Signals in Single Cells by Eroglu, Emrah, Rost, Rene, Bischof, Helmut, Blass, Sandra, Schreilechner, Anna, Gottschalk, Benjamin, Depaoli, Maria R., Klec, Christiane, Charoensin, Suphachai, Madreiter-Sokolowski, Corina T., Ramadani, Jeta, Waldeck-Weiermair, Markus, Graier, Wolfgang F., Malli, Roland

Get full text

Presenilin-1 Established ER-Ca 2+ Leak: a Follow Up on Its Importance for the Initial Insulin Secretion in Pancreatic Islets and β-Cells upon Elevated Glucose by Klec, Christiane, Madreiter-Sokolowski, Corina T, Ziomek, Gabriela, Stryeck, Sarah, Sachdev, Vinay, Duta-Mare, Madalina, Gottschalk, Benjamin, Depaoli, Maria R, Rost, Rene, Hay, Jesse, Waldeck-Weiermair, Markus, Kratky, Dagmar, Madl, Tobias, Malli, Roland, Graier, Wolfgang F

“…In our recent work, the importance of GSK3β-mediated phosphorylation of presenilin-1 as crucial process to establish a Ca leak in the endoplasmic reticulum…”
Get full text