In vivo serial diffusion tensor imaging of experimental spinal cord injury

In vivo serial diffusion tensor imaging of experimental spinal cord injury

In vivo longitudinal diffusion tensor imaging (DTI) of rodent spinal cord injury (SCI) was carried out over a period of eight weeks post‐injury. A balanced, rotationally invariant, alternating gradient polarity icosahedral diffusion encoding scheme was used for an unbiased estimation of the DTI metr...

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Bibliographic Details
Published in:Journal of neuroscience research Vol. 83; no. 5; pp. 801 - 810
Main Authors: Deo, Aparna A., Grill, Raymond J., Hasan, Khader M., Narayana, Ponnada A.
Format: Journal Article
Language:English
Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01-04-2006
Subjects:
Animals
Anisotropy
Diffusion Magnetic Resonance Imaging
Disease Models, Animal
DTI
eigenvalues
longitudinal diffusivity
Male
MRI
Radiography
Rats
Rats, Sprague-Dawley
Spinal Cord Injuries - diagnostic imaging
Spinal Cord Injuries - pathology
spinal cord injury
transverse diffusivity
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Summary:In vivo longitudinal diffusion tensor imaging (DTI) of rodent spinal cord injury (SCI) was carried out over a period of eight weeks post‐injury. A balanced, rotationally invariant, alternating gradient polarity icosahedral diffusion encoding scheme was used for an unbiased estimation of the DTI metrics. The fractional anisotropy (FA), diffusivities along (longitudinal), and perpendicular (transverse) to the fiber tracts, were estimated for the ventral, dorsal, and lateral white matter. In all the three regions, the DTI metrics were observed to be significantly different in injured cords relative to the uninjured controls close to the epicenter of the injury. However, these differences gradually disappeared away from the epicenter. The spatio‐temporal changes in the DTI metrics showed a recovery pattern that is region specific. Although the temporal trends in the tissue recovery in rostral and caudal sections seem to be similar, overall the DTI metrics were observed to be closer to the normal tissue values in the caudal relative to the rostral sections (rostral–caudal asymmetry). © 2006 Wiley‐Liss, Inc.
Bibliography:istex:75EDF000A0A61443AF469D8562F76DDE22CE4069
ArticleID:JNR20783
ark:/67375/WNG-BD4D1SPL-J
NIH - No. NS045624; No. NS 30821
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0360-4012
1097-4547
DOI:10.1002/jnr.20783