Search Results - "Denvir, Martin A."

Chest pain presentations to hospital during the COVID-19 lockdown: Lessons for public health media campaigns by Ferry, Amy V, Keanie, Collette, Denvir, Martin A, Mills, Nicholas L, Strachan, Fiona E

“…Emergency Department (ED) attendances with chest pain reduced during the COVID-19 lockdown. We performed a service evaluation project in NHS Lothian to explore…”
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Adaptive prospective optical gating enables day-long 3D time-lapse imaging of the beating embryonic zebrafish heart by Taylor, Jonathan M., Nelson, Carl J., Bruton, Finnius A., Kaveh, Aryan, Buckley, Charlotte, Tucker, Carl S., Rossi, Adriano G., Mullins, John J., Denvir, Martin A.

“…Three-dimensional fluorescence time-lapse imaging of the beating heart is extremely challenging, due to the heart’s constant motion and a need to avoid…”
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Nuclear S-nitrosylation impacts tissue regeneration in zebrafish by Matrone, Gianfranco, Jung, Sung Yun, Choi, Jong Min, Jain, Antrix, Leung, Hon-Chiu Eastwood, Rajapakshe, Kimal, Coarfa, Cristian, Rodor, Julie, Denvir, Martin A., Baker, Andrew H., Cooke, John P.

“…Despite the importance of nitric oxide signaling in multiple biological processes, its role in tissue regeneration remains largely unexplored. Here, we provide…”
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Frailty assessment and risk prediction by GRACE score in older patients with acute myocardial infarction by Anand, Atul, Cudmore, Sarah, Robertson, Shirley, Stephen, Jacqueline, Haga, Kristin, Weir, Christopher J, Murray, Scott A, Boyd, Kirsty, Gunn, Julian, Iqbal, Javaid, MacLullich, Alasdair, Shenkin, Susan D, Fox, Keith A A, Mills, Nicholas, Denvir, Martin A

“…Risk prediction after myocardial infarction is often complex in older patients. The Global Registry of Acute Coronary Events (GRACE) model includes clinical…”
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Author Correction: Adaptive prospective optical gating enables day-long 3D time-lapse imaging of the beating embryonic zebrafish heart by Taylor, Jonathan M., Nelson, Carl J., Bruton, Finnius A., Kaveh, Aryan, Buckley, Charlotte, Tucker, Carl S., Rossi, Adriano G., Mullins, John J., Denvir, Martin A.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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PET/CT Technology in Adult Zebrafish: A Pilot Study Toward Live Longitudinal Imaging by Tucker, Carl, Collins, Richard, Denvir, Martin A, McDougald, Wendy A

“…Decades of research have confirmed the beneficial and advantageous use of zebrafish ( ) as a model of human disease in biomedical studies. Not only are 71% of…”
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Effects of Cyclin Dependent Kinase 9 inhibition on zebrafish larvae by Matrone, Gianfranco, Mullins, John J, Tucker, Carl S, Denvir, Martin A

“…CDK9 is a known regulator of cellular transcription, growth and proliferation. Small molecule inhibitors are currently being developed and assessed in clinical…”
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Influence of Androgen Receptor in Vascular Cells on Reperfusion following Hindlimb Ischaemia by Wu, Junxi, Hadoke, Patrick W F, Takov, Kaloyan, Korczak, Agnieszka, Denvir, Martin A, Smith, Lee B

“…Studies in global androgen receptor knockout (G-ARKO) and orchidectomised mice suggest that androgen accelerates reperfusion of the ischaemic hindlimb by…”
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Live Imaging of Heart Injury in Larval Zebrafish Reveals a Multi-Stage Model of Neutrophil and Macrophage Migration by Kaveh, Aryan, Bruton, Finnius A, Buckley, Charlotte, Oremek, Magdalena E M, Tucker, Carl S, Mullins, John J, Taylor, Jonathan M, Rossi, Adriano G, Denvir, Martin A

“…Neutrophils and macrophages are crucial effectors and modulators of repair and regeneration following myocardial infarction, but they cannot be easily observed…”
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Heart on a plate: histological and functional assessment of isolated adult zebrafish hearts maintained in culture by Pieperhoff, Sebastian, Wilson, Kathryn S, Baily, James, de Mora, Kim, Maqsood, Sana, Vass, Sharron, Taylor, Jonathan, Del-Pozo, Jorge, MacRae, Calum A, Mullins, John J, Denvir, Martin A

“…The zebrafish is increasingly used for cardiovascular genetic and functional studies. We present a novel protocol to maintain and monitor whole isolated…”
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Elevated plasma levels of cardiac troponin-I predict left ventricular systolic dysfunction in patients with myotonic dystrophy type 1: A multicentre cohort follow-up study by Hamilton, Mark J, Robb, Yvonne, Cumming, Sarah, Gregory, Helen, Duncan, Alexis, Rahman, Monika, McKeown, Anne, McWilliam, Catherine, Dean, John, Wilcox, Alison, Farrugia, Maria E, Cooper, Anneli, McGhie, Josephine, Adam, Berit, Petty, Richard, Longman, Cheryl, Findlay, Iain, Japp, Alan, Monckton, Darren G, Denvir, Martin A

“…High sensitivity plasma cardiac troponin-I (cTnI) is emerging as a strong predictor of cardiac events in a variety of settings. We have explored its utility in…”
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Haploinsufficiency of the murine Col3a1 locus causes aortic dissection: a novel model of the vascular type of Ehlers- Danlos syndrome by SMITH, Lee B, HADOKE, Patrick W. F, DYER, Emma, DENVIR, Martin A, BROWNSTEIN, David, MILLER, Eileen, NELSON, Nancy, WELLS, Sara, CHEESEMAN, Michael, GREENFIELD, Andy

“…The vascular type of Ehlers-Danlos syndrome (EDS IV) is an autosomal-dominant disorder characterized by thin translucent skin and extensive bruising. Patients…”
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Laser-targeted ablation of the zebrafish embryonic ventricle: A novel model of cardiac injury and repair by Matrone, Gianfranco, Taylor, Jonathan M, Wilson, Kathryn S, Baily, James, Love, Gordon D, Girkin, John M, Mullins, John J, Tucker, Carl S, Denvir, Martin A

“…Abstract Background While the adult zebrafish ( Danio rerio ) heart demonstrates a remarkable capacity for self-renewal following apical resection little is…”
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Systolic and diastolic ventricular function in zebrafish embryos: influence of norepenephrine, MS-222 and temperature by Denvir, Martin A, Tucker, Carl S, Mullins, John J

“…Zebrafish are increasingly used to study the influences of gene mutation and manipulation on cardiac development, structure and function. In this study, a…”
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Correction: Elevated plasma levels of cardiac troponin-I predict left ventricular systolic dysfunction in patients with myotonic dystrophy type 1: A multicentre cohort follow-up study by Hamilton, Mark J, Robb, Yvonne, Cumming, Sarah, Gregory, Helen, Duncan, Alexis, Rahman, Monika, McKeown, Anne, McWilliam, Catherine, Dean, John, Wilcox, Alison, Farrugia, Maria E, Cooper, Anneli, McGhie, Josephine, Adam, Berit, Petty, Richard, Longman, Cheryl, Findlay, Iain, Japp, Alan, Monckton, Darren G, Denvir, Martin A

“…[This corrects the article DOI: 10.1371/journal.pone.0174166.]…”
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Identifying acute coronary syndrome patients approaching end-of-life by Fenning, Stephen, Woolcock, Rebecca, Haga, Kristin, Iqbal, Javaid, Fox, Keith A, Murray, Scott A, Denvir, Martin A

“…Acute coronary syndrome (ACS) is common in patients approaching the end-of-life (EoL), but these patients rarely receive palliative care. We compared the…”
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Cardiac Energetics Before, During, and After Anthracycline-Based Chemotherapy in Breast Cancer Patients Using 31P Magnetic Resonance Spectroscopy: A Pilot Study by Macnaught, Gillian, Oikonomidou, Olga, Rodgers, Christopher T., Clarke, William, Cooper, Annette, McVicars, Heather, Hayward, Larry, Mirsadraee, Saeed, Semple, Scott, Denvir, Martin A.

“…Purpose: To explore the utility of phosphorus magnetic resonance spectroscopy ( 31 P MRS) in identifying anthracycline-induced cardiac toxicity in patients…”
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Cardiomyocyte proliferation in zebrafish and mammals: lessons for human disease by Matrone, Gianfranco, Tucker, Carl S., Denvir, Martin A.

“…Cardiomyocytes proliferate profusely during early development and for a brief period after birth in mammals. Within a month after birth, this proliferative…”
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Criteria for Referral of Patients With Advanced Heart Failure for Specialized Palliative Care by Chang, Yuchieh Kathryn, Allen, Larry A, McClung, John A, Denvir, Martin A, Philip, Jennifer, Mori, Masanori, Perez-Cruz, Pedro, Cheng, Shao-Yi, Collins, Anna, Hui, David

“…Patients with advanced heart failure have substantial supportive care needs. Specialist palliative care can be beneficial, but it is unclear who is most…”
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Clinical endpoint adjudication by Meah, Mohammed N, Denvir, Martin A, Mills, Nicholas L, Norrie, John, Newby, David E

“…In pivotal clinical effectiveness trials, the primary endpoint needs to be precisely defined and quantified because any misclassification could introduce noise…”
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