Search Results - "Denu, John M."

Activation of the Protein Deacetylase SIRT6 by Long-chain Fatty Acids and Widespread Deacylation by Mammalian Sirtuins by Feldman, Jessica L., Baeza, Josue, Denu, John M.

“…Mammalian sirtuins (SIRT1 through SIRT7) are members of a highly conserved family of NAD+-dependent protein deacetylases that function in metabolism, genome…”
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Mechanisms and Dynamics of Protein Acetylation in Mitochondria by Baeza, Josue, Smallegan, Michael J., Denu, John M.

“…Reversible protein acetylation is a major regulatory mechanism for controlling protein function. Through genetic manipulations, dietary perturbations, and new…”
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Biological and catalytic functions of sirtuin 6 as targets for small-molecule modulators by Klein, Mark A., Denu, John M.

“…Sirtuin 6 (SIRT6) is a nuclear NAD+-dependent deacetylase of histone H3 that regulates genome stability and gene expression. However, nonhistone substrates and…”
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SIRT3 Protein Deacetylates Isocitrate Dehydrogenase 2 (IDH2) and Regulates Mitochondrial Redox Status by Yu, Wei, Dittenhafer-Reed, Kristin E., Denu, John M.

“…Mitochondria play a central role in oxidative energy metabolism and age-related diseases such as cancer. Accumulation of spurious oxidative damage can cause…”
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Short-chain fatty acids activate acetyltransferase p300 by Thomas, Sydney P, Denu, John M

“…Short-chain fatty acids (SCFAs) acetate, propionate, and butyrate are produced in large quantities by the gut microbiome and contribute to a wide array of…”
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Metabolism and the Epigenome: A Dynamic Relationship by Haws, Spencer A., Leech, Cassandra M., Denu, John M.

“…Many chromatin-modifying enzymes require metabolic cofactors to support their catalytic activities, providing a direct path for fluctuations in metabolite…”
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The Deacetylase Sirt6 Activates the Acetyltransferase GCN5 and Suppresses Hepatic Gluconeogenesis by Dominy, John E., Lee, Yoonjin, Jedrychowski, Mark P., Chim, Helen, Jurczak, Michael J., Camporez, Joao Paulo, Ruan, Hai-Bin, Feldman, Jessica, Pierce, Kerry, Mostoslavsky, Raul, Denu, John M., Clish, Clary B., Yang, Xiaoyong, Shulman, Gerald I., Gygi, Steven P., Puigserver, Pere

“…Hepatic glucose production (HGP) maintains blood glucose levels during fasting but can also exacerbate diabetic hyperglycemia. HGP is dynamically controlled by…”
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Metabolic Regulation of Histone Post-Translational Modifications by Fan, Jing, Krautkramer, Kimberly A, Feldman, Jessica L, Denu, John M

“…Histone post-translational modifications regulate transcription and other DNA-templated functions. This process is dynamically regulated by specific modifying…”
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Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric Restriction by Someya, Shinichi, Yu, Wei, Hallows, William C., Xu, Jinze, Vann, James M., Leeuwenburgh, Christiaan, Tanokura, Masaru, Denu, John M., Prolla, Tomas A.

“…Caloric restriction (CR) extends the life span and health span of a variety of species and slows the progression of age-related hearing loss (AHL), a common…”
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Site-Specific Reactivity of Nonenzymatic Lysine Acetylation by Baeza, Josue, Smallegan, Michael J, Denu, John M

“…Protein acetylation of lysine ε-amino groups is abundant in cells, particularly within mitochondria. The contribution of enzyme-catalyzed and nonenzymatic…”
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Chemical mechanisms of histone lysine and arginine modifications by Smith, Brian C., Denu, John M.

“…Histone lysine and arginine residues are subject to a wide array of post-translational modifications including methylation, citrullination, acetylation,…”
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Regulation of Glycolytic Enzyme Phosphoglycerate Mutase-1 by Sirt1 Protein-mediated Deacetylation by Hallows, William C., Yu, Wei, Denu, John M.

“…Emerging proteomic evidence suggests that acetylation of metabolic enzymes is a prevalent post-translational modification. In a few recent reports, acetylation…”
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Sirtuins Deacetylate and Activate Mammalian Acetyl-CoA Synthetases by Hallows, William C., Lee, Susan, Denu, John M.

“…Silent Information Regulator 2 (Sir2) enzymes (or sirtuins) are NAD⁺-dependent deacetylases that modulate gene silencing, aging and energy metabolism. Previous…”
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The Sirtuin family: therapeutic targets to treat diseases of aging by Milne, Jill C, Denu, John M

“…Sirtuins have emerged as therapeutic targets to treat age-related diseases. There are seven human Sirtuins (SIRT1–7) that display diversity in cellular…”
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Kinetic and Structural Basis for Acyl-Group Selectivity and NAD+ Dependence in Sirtuin-Catalyzed Deacylation by Feldman, Jessica L, Dittenhafer-Reed, Kristin E, Kudo, Norio, Thelen, Julie N, Ito, Akihiro, Yoshida, Minoru, Denu, John M

“…Acylation of lysine is an important protein modification regulating diverse biological processes. It was recently demonstrated that members of the human…”
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Circadian Clock NAD⁺ Cycle Drives Mitochondrial Oxidative Metabolism in Mice by Peek, Clara Bien, Affinati, Alison H., Ramsey, Kathryn Moynihan, Kuo, Hsin-Yu, Yu, Wei, Sena, Laura A., Ilkayeva, Olga, Marcheva, Biliana, Kobayashi, Yumiko, Omura, Chiaki, Levine, Daniel C., Bacsik, David J., Gius, David, Newgard, Christopher B., Goetzman, Eric, Chandel, Navdeep S., Denu, John M., Mrksich, Milan, Bass, Joseph

“…Circadian clocks are self-sustained cellular oscillators that synchronize oxidative and reductive cycles in anticipation of the solar cycle. We found that the…”
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Catalysis and substrate selection by histone/protein lysine acetyltransferases by Berndsen, Christopher E, Denu, John M

“…Reversible protein acetylation is controlled by the opposing actions of protein lysine acetyltransferases and deacetylations. Recent developments on the…”
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Dual recognition of H3K4me3 and H3K27me3 by a plant histone reader SHL by Qian, Shuiming, Lv, Xinchen, Scheid, Ray N., Lu, Li, Yang, Zhenlin, Chen, Wei, Liu, Rui, Boersma, Melissa D., Denu, John M., Zhong, Xuehua, Du, Jiamu

“…The ability of a cell to dynamically switch its chromatin between different functional states constitutes a key mechanism regulating gene expression. Histone…”
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Interactions between Roseburia intestinalis and diet modulate atherogenesis in a murine model by Kasahara, Kazuyuki, Krautkramer, Kimberly A., Org, Elin, Romano, Kymberleigh A., Kerby, Robert L., Vivas, Eugenio I., Mehrabian, Margarete, Denu, John M., Bäckhed, Fredrik, Lusis, Aldons J., Rey, Federico E.

“…Humans with metabolic and inflammatory diseases frequently harbour lower levels of butyrate-producing bacteria in their gut. However, it is not known whether…”
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SIRT3 Mediates Multi-Tissue Coupling for Metabolic Fuel Switching by Dittenhafer-Reed, Kristin E., Richards, Alicia L., Fan, Jing, Smallegan, Michael J., Fotuhi Siahpirani, Alireza, Kemmerer, Zachary A., Prolla, Tomas A., Roy, Sushmita, Coon, Joshua J., Denu, John M.

“…SIRT3 is a member of the Sirtuin family of NAD+-dependent deacylases and plays a critical role in metabolic regulation. Organism-wide SIRT3 loss manifests in…”
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