Search Results - "Denton, Ryan"

Documenting and harnessing the biological potential of molecules in Distributed Drug Discovery (D3) virtual catalogs by Abraham, Milata M., Denton, Ryan E., Harper, Richard W., Scott, William L., O'Donnell, Martin J., Durrant, Jacob D.

“…Virtual molecular catalogs have limited utility if member compounds are (i) difficult to synthesize or (ii) unlikely to have biological activity. The…”
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Distributed Drug Discovery: Advancing Chemical Education through Contextualized Combinatorial Solid-Phase Organic Laboratories by Scott, William L, Denton, Ryan E, Marrs, Kathleen A, Durrant, Jacob D, Samaritoni, J. Geno, Abraham, Milata M, Brown, Stephen P, Carnahan, Jon M, Fischer, Lindsey G, Glos, Courtney E, Sempsrott, Peter J, O’Donnell, Martin J

“…The Distributed Drug Discovery (D3) program trains students in three drug discovery disciplines (synthesis, computational analysis, and biological screening)…”
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Nitrogen dioxide reducing ascorbic acid technologies in the ventilator circuit leads to uniform NO concentration during inspiration by Pezone, Matthew J., Wakim, Matthew G., Denton, Ryan J., Gamero, Lucas G., Roscigno, Robert F., Gilbert, Richard J., Lovich, Mark A.

“…Conventional inhaled NO systems deliver NO by synchronized injection or continuous NO flow in the ventilator circuitry. Such methods can lead to variable…”
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Generation of purified nitric oxide from liquid N2O4 for the treatment of pulmonary hypertension in hypoxemic swine by Lovich, Mark A., Fine, David H., Denton, Ryan J., Wakim, Matt G., Wei, Abraham E., Maslov, Mikhail Y., Gamero, Lucas G., Vasquez, Gregory B., Johnson, Bryan J., Roscigno, Robert F., Gilbert, Richard J.

“…•Ambulatory systems for delivering NO have been limited by the size of storage tanks.•We present a novel method for generating inhaled NO from liquid N2O4.•The…”
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Inhaled Nitric Oxide Augments Left Ventricular Assist Device Capacity by Ameliorating Secondary Right Ventricular Failure by Lovich, Mark A, Pezone, Matthew J, Wakim, Matthew G, Denton, Ryan J, Maslov, Mikhail Y, Murray, Michael R, Tsukada, Hisashi, Agnihotri, Arvind K, Roscigno, Robert F, Gamero, Lucas G, Gilbert, Richard J

“…Clinical right ventricular (RV) impairment can occur with left ventricular assist device (LVAD) use, thereby compromising the therapeutic effectiveness. The…”
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NITRIC OXIDE TREATMENT OF RV FAILURE ASSOCIATED WITH THE USE OF A LEFT VENTRICULAR ASSIST DEVICE AND HYPOXEMIA-INDUCED PULMONARY HYPERTENSION by Lovich, Mark A, Wakim, Mathew G, Maslov, Mikhail Y, Murray, Michael R, Pezone, Mathew J, Tsukada, Hisashi, Agnihotri, Arvind K, Denton, Ryan J, Gamero, Lucas G, Vasquez, Gregory B, Johnson, Bryan J, Roscigno, Robert F, Richard, Gilbert J

“…Inhaled NO decreased pulmonary vascular resistance (PVR, 7.0 ± 0.3 vs. 4.1 ± 0.4 WU, P = 0.0001) and increased the critical achievable pump speed prior to the…”
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Cloning, expression and characterization of lepidopteran isopentenyl diphosphate isomerase by Sen, Stephanie E, Tomasello, Ashley, Grasso, Michael, Denton, Ryan, Macor, Joseph, Béliveau, Catherine, Cusson, Michel, Crowell, Dring N

“…Isopentenyl diphosphate isomerase (IPPI) of the spruce budworm, Choristoneura fumiferana, and of the tobacco hornworm, Manduca sexta, was cloned and its…”
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Kinetic study of competitive catalytic transfer hydrogenation on a multi-functional molecule: 4-benzyloxy-4′-chlorochalcone by Nguyen, Tyler, Arciero, Julia, Piltz, Joshua, Hartley, K. Danielle, Rickard, Timothy, Denton, Ryan

“…A combined chemical and mathematical approach was used to study the reduction process of 4-benzyloxy-4′-chlorochalcone involving catalytic transfer…”
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Abstract 9779: Nitric Oxide Generated Through Ascorbic Acid Reduction of Nitrogen Dioxide Reduces Pulmonary Vascular Resistance in Hypoxemic Swine with Minimal Inhaled and Exhaled Nitrogen Dioxide by Lovich, Mark A, Bruno, Natalie K, Wei, Abraham E, Maslov, Mikhail Y, Denton, Ryan J, Gamero, Lucas G, Vasquez, Gregory B, Gilbert, Richard J

“…Abstract only Background: Inhaled nitric oxide (NO) has the capacity to selectively dilate pulmonary blood vessels and improve oxygenation in patients with…”
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Arabidopsis thaliana plants possess a specific farnesylcysteine lyase that is involved in detoxification and recycling of farnesylcysteine by Crowell, Dring N, Huizinga, David H, Deem, Angela K, Trobaugh, Corey, Denton, Ryan, Sen, Stephanie E

“…In plants, prenylated proteins are involved in actin organization, calcium-mediated signal transduction, and many other biological processes. Arabidopsis…”
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Farnesylcysteine Lyase is Involved in Negative Regulation of Abscisic Acid Signaling in Arabidopsis by Huizinga, David H., Denton, Ryan, Koehler, Kelly G., Tomasello, Ashley, Wood, Lyndsay, Sen, Stephanie E., Crowell, Dring N.

“…The Arabidopsis FCLY gene encodes a specific farnesylcysteine (FC) lyase, which is responsible for the oxidative metabolism of FC to farnesal and cysteine. In…”
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Isoprenoid metabolism in lepidopteran insects and plants by Denton, Ryan Edward

“…Isoprenoids are important biological molecules required for a variety of metabolic processes, including electron transport (ubiquinones), glycoprotein…”
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Farnesylcysteine Lyase Regulation of Abscisic Arabidopsis is Involved in Negative Acid Signaling in by David H. Huizinga Ryan Denton Kelly G. Koehler Ashley Tomasello Lyndsay Wood Stephanie E. Sen Dring N. Crowell

“…The Arabidopsis FCLY gene encodes a specific farnesylcysteine （FC） lyase, which is responsible for the oxidative metabolism of FC to farnesal and cysteine. In…”
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Exploration of donor /acceptor carbenoids in the asymmetric synthesis of cyclopropanes utilizing rhodium(II) catalysis by Denton, Justin Ryan

“…In the Davies group there are three research areas: methodology development, the total synthesis of natural products, and catalyst design & development…”
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Exploration of donor/acceptor carbenoids in the asymmetric synthesis of cyclopropanes utilizing rhodium(II) catalysis by Denton, Justin Ryan

“…In the Davies group there are three research areas: methodology development, the total synthesis of natural products, and catalyst design & development…”
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