Search Results - "Denti, Luca"
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PangeBlocks: customized construction of pangenome graphs via maximal blocks
Published in BMC bioinformatics (04-11-2024)“…Abstract Background The construction of a pangenome graph is a fundamental task in pangenomics. A natural theoretical question is how to formalize the…”
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MALVIRUS: an integrated application for viral variant analysis
Published in BMC bioinformatics (19-04-2022)“…Being able to efficiently call variants from the increasing amount of sequencing data daily produced from multiple viral strains is of the utmost importance,…”
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ASGAL: aligning RNA-Seq data to a splicing graph to detect novel alternative splicing events
Published in BMC bioinformatics (20-11-2018)“…While the reconstruction of transcripts from a sample of RNA-Seq data is a computationally expensive and complicated task, the detection of splicing events…”
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MALVA: Genotyping by Mapping-free ALlele Detection of Known VAriants
Published in iScience (30-08-2019)“…The amount of genetic variation discovered in human populations is growing rapidly leading to challenging computational tasks, such as variant calling…”
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Mechanical Cues, E-Cadherin Expression and Cell "Sociality" Are Crucial Crossroads in Determining Pancreatic Ductal Adenocarcinoma Cells Behavior
Published in Cells (Basel, Switzerland) (13-04-2022)“…E-cadherin, an epithelial-to-mesenchymal transition (EMT) marker, is coupled to actin cytoskeleton and distributes cell forces acting on cells. Since YAP…”
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Simvastatin Prevents Liver Microthrombosis and Sepsis Induced Coagulopathy in a Rat Model of Endotoxemia
Published in Cells (Basel, Switzerland) (29-03-2022)“…Background: Endotoxemia causes endothelial dysfunction and microthrombosis, which are pathogenic mechanisms of coagulopathy and organ failure during sepsis…”
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Polyblend Nanofibers to Regenerate Gingival Tissue: A Preliminary In Vitro Study
Published in Frontiers in materials (04-06-2021)“…Aim: The regeneration of small periodontal defects has been considered an important divide and challenging issue for dental practitioners. The aim of this…”
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Antiparasitic Drugs against SARS-CoV-2: A Comprehensive Literature Survey
Published in Microorganisms (Basel) (24-06-2022)“…More than two years have passed since the viral outbreak that led to the novel infectious respiratory disease COVID-19, caused by the SARS-CoV-2 coronavirus…”
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SVDSS: structural variation discovery in hard-to-call genomic regions using sample-specific strings from accurate long reads
Published in Nature methods (01-04-2023)“…Structural variants (SVs) account for a large amount of sequence variability across genomes and play an important role in human genomics and precision…”
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Triplet-based similarity score for fully multilabeled trees with poly-occurring labels
Published in Bioinformatics (19-04-2021)“…Abstract Motivation The latest advances in cancer sequencing, and the availability of a wide range of methods to infer the evolutionary history of tumors, have…”
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Shark: fishing relevant reads in an RNA-Seq sample
Published in Bioinformatics (01-05-2021)“…Abstract Motivation Recent advances in high-throughput RNA-Seq technologies allow to produce massive datasets. When a study focuses only on a handful of genes,…”
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RecGraph: recombination-aware alignment of sequences to variation graphs
Published in Bioinformatics (Oxford, England) (02-05-2024)“…Abstract Motivation Bacterial genomes present more variability than human genomes, which requires important adjustments in computational tools that are…”
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Comparative genome analysis using sample-specific string detection in accurate long reads
Published in Bioinformatics advances (2021)“…Comparative genome analysis of two or more whole-genome sequenced (WGS) samples is at the core of most applications in genomics. These include the discovery of…”
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MALVA: Genotyping by Mapping-free ALlele Detection of Known VAriants
Published in iScience (2019)“…The amount of genetic variation discovered and characterized in human populations is huge, and is growing rapidly with the widespread availability of modern…”
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