Search Results - "Dent, Joseph A"

Stoichiometry of the human glycine receptor revealed by direct subunit counting by Durisic, Nela, Godin, Antoine G, Wever, Claudia M, Heyes, Colin D, Lakadamyali, Melike, Dent, Joseph A

“…The subunit stoichiometry of heteromeric glycine-gated channels determines fundamental properties of these key inhibitory neurotransmitter receptors; however,…”
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The Validation of Nematode-Specific Acetylcholine-Gated Chloride Channels as Potential Anthelmintic Drug Targets by Wever, Claudia M, Farrington, Danielle, Dent, Joseph A

“…New compounds are needed to treat parasitic nematode infections in humans, livestock and plants. Small molecule anthelmintics are the primary means of nematode…”
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Molecular cloning and characterization of novel glutamate-gated chloride channel subunits from Schistosoma mansoni by Dufour, Vanessa, Beech, Robin N, Wever, Claudia, Dent, Joseph A, Geary, Timothy G

“…Cys-loop ligand-gated ion channels (LGICs) mediate fast ionotropic neurotransmission. They are proven drug targets in nematodes and arthropods, but are poorly…”
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Food perception without ingestion leads to metabolic changes and irreversible developmental arrest in C. elegans by Kaplan, Rebecca E W, Webster, Amy K, Chitrakar, Rojin, Dent, Joseph A, Baugh, L Ryan

“…Developmental physiology is very sensitive to nutrient availability. For instance, in the nematode Caenorhabditis elegans, newly hatched L1-stage larvae…”
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Recent Duplication and Functional Divergence in Parasitic Nematode Levamisole-Sensitive Acetylcholine Receptors by Duguet, Thomas B, Charvet, Claude L, Forrester, Sean G, Wever, Claudia M, Dent, Joseph A, Neveu, Cedric, Beech, Robin N

“…Helminth parasites rely on fast-synaptic transmission in their neuromusculature to experience the outside world and respond to it. Acetylcholine plays a…”
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A Family of Acetylcholine-gated Chloride Channel Subunits in Caenorhabditis elegans by Putrenko, Igor, Zakikhani, Mahvash, Dent, Joseph A.

“…The genome of the nematode Caenorhabditis elegans encodes a surprisingly large and diverse superfamily of genes encoding Cys loop ligand-gated ion channels…”
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The Genetics of Ivermectin Resistance in Caenorhabditis elegans by Dent, J A, Smith, M M, Vassilatis, D K, Avery, L

“…The ability of organisms to evolve resistance threatens the effectiveness of every antibiotic drug. We show that in the nematode Caenorhabditis elegans,…”
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Evidence for a diverse Cys-loop ligand-gated ion channel superfamily in early bilateria by Dent, Joseph A

“…The genome sequences of Caenorhabditis elegans and Drosophila melanogaster reveal a diversity of cysteine-loop ligand-gated ion channels (Cys-loop LGICs) not…”
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The orphan pentameric ligand-gated ion channel pHCl-2 is gated by pH and regulates fluid secretion in Drosophila Malpighian tubules by Feingold, Daniel, Starc, Tanja, O'Donnell, Michael J, Nilson, Laura, Dent, Joseph A

“…Pentameric ligand-gated ion channels (pLGICs) constitute a large protein superfamily in metazoa whose role as neurotransmitter receptors mediating rapid,…”
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secCl is a cys-loop ion channel necessary for the chloride conductance that mediates hormone-induced fluid secretion in Drosophila by Feingold, Daniel, Knogler, Laura, Starc, Tanja, Drapeau, Pierre, O’Donnell, Michael J., Nilson, Laura A., Dent, Joseph A.

“…Organisms use circulating diuretic hormones to control water balance (osmolarity), thereby avoiding dehydration and managing excretion of waste products. The…”
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Nematode parasite genes: what's in a name? by Beech, Robin N, Wolstenholme, Adrian J, Neveu, Cédric, Dent, Joseph A

“…The central theme of Shakespeare's Romeo and Juliet is that names are meaningless, artificial constructs, detached from any underlying reality. By contrast, we…”
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The evolution of pentameric ligand-gated ion channels by Dent, Joseph A

“…Fast, ionotropic neurotransmission mediated by ligand-gated ion channels is essential for timely behavioral responses in multicellular organisms. Metazoa…”
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The serotonin receptor SER‐1 (5HT2ce) contributes to the regulation of locomotion in Caenorhabditis elegans by Dernovici, Serge, Starc, Tanja, Dent, Joseph A., Ribeiro, Paula

“…Serotonin (5‐hydroxytryptamine: 5HT) is an important neuroactive substance in the model roundworm, Caenorhabditis elegans. Aside from having effects in feeding…”
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Reversal Frequency in Caenorhabditis elegans Represents an Integrated Response to the State of the Animal and Its Environment by Zhao, Beibei, Khare, Parul, Feldman, Lisa, Dent, Joseph A

“…The locomotion of Caenorhabditis elegans consists of forward crawling punctuated by spontaneous reversals. To better understand the important variables that…”
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avr-15 encodes a chloride channel subunit that mediates inhibitory glutamatergic neurotransmission and ivermectin sensitivity in Caenorhabditis elegans by Dent, Joseph A., Davis, M.Wayne, Avery, Leon

“…Ivermectin is a widely used anthelmintic drug whose nematocidal mechanism is incompletely understood. We have used Caenorhabditis elegans as a model system to…”
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What Can Caenorhabditis elegans Tell Us About Nematiocides and Parasites\ulcorner by Dent, Joseph A

“…Nematode infections compromise human health and reduce agricultural productivtiy. Experiments that exploit the powerful molecular genetics of the free-living…”
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Molecular characterisation of a pH-gated chloride channel from Sarcoptes scabiei by Mounsey, Kate E, Dent, Joseph A, Holt, Deborah C, McCarthy, James, Currie, Bart J, Walton, Shelley F

“…Reports of ivermectin resistance in scabies mites raise concerns regarding the sustainability of mass intervention programs for scabies worldwide and for the…”
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Regulation of intermuscular electrical coupling by the Caenorhabditis elegans innexin inx-6 by Li, Shaolin, Dent, Joseph A, Roy, Richard

“…The innexins represent a highly conserved protein family, the members of which make up the structural components of gap junctions in invertebrates. We have…”
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Haemonchus contortus: HcGluCla expressed in Xenopus oocytes forms a glutamate-gated ion channel that is activated by ibotenate and the antiparasitic drug ivermectin by Forrester, Sean G., Prichard, Roger K., Dent, Joseph A., Beech, Robin N.

“…Ion channels are targets for many drugs including insecticides and anthelminthic agents such as ivermectin (IVM) and moxidectin (MOX). IVM has been shown to…”
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EAT-20, a Novel Transmembrane Protein With EGF Motifs, Is Required for Efficient Feeding in Caenorhabditis elegans by Shibata, Yukimasa, Fujii, Takashi, Dent, Joseph A, Fujisawa, Hajime, Takagi, Shin

“…The pharynx of Caenorhabditis elegans is a neuromuscular organ responsible for feeding, concentrating food by its pumping movement. A class of mutants, the eat…”
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