Search Results - "Dent, Jessica R."

Resistance exercise initiates mechanistic target of rapamycin (mTOR) translocation and protein complex co-localisation in human skeletal muscle by Song, Zhe, Moore, Daniel R., Hodson, Nathan, Ward, Carl, Dent, Jessica R., O’Leary, Mary F., Shaw, Andrew M., Hamilton, D. Lee, Sarkar, Sovan, Gangloff, Yann-Gaël, Hornberger, Troy A., Spriet, Lawrence L., Heigenhauser, George J., Philp, Andrew

“…The mechanistic target of rapamycin (mTOR) is a central mediator of protein synthesis in skeletal muscle. We utilized immunofluorescence approaches to study…”
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Skeletal Muscle Fibre-Specific Knockout of p53 Does Not Reduce Mitochondrial Content or Enzyme Activity by Stocks, Ben, Dent, Jessica R, Joanisse, Sophie, McCurdy, Carrie E, Philp, Andrew

“…Tumour protein 53 (p53) has been implicated in the regulation of mitochondrial biogenesis in skeletal muscle, with whole-body p53 knockout mice displaying…”
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Muscle-specific knockout of general control of amino acid synthesis 5 (GCN5) does not enhance basal or endurance exercise-induced mitochondrial adaptation by Dent, Jessica R, Martins, Vitor F, Svensson, Kristoffer, LaBarge, Samuel A, Schlenk, Noah C, Esparza, Mary C, Buckner, Elisa H, Meyer, Gretchen A, Hamilton, D Lee, Schenk, Simon, Philp, Andrew

“…Lysine acetylation is an important post-translational modification that regulates metabolic function in skeletal muscle. The acetyltransferase, general control…”
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Transient changes to metabolic homeostasis initiate mitochondrial adaptation to endurance exercise by Dent, Jessica R., Stocks, Ben, Campelj, Dean G., Philp, Andrew

“…Endurance exercise is well established to increase mitochondrial content and function in skeletal muscle, a process termed mitochondrial biogenesis. Current…”
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Defining the contribution of skeletal muscle pyruvate dehydrogenase α1 to exercise performance and insulin action by Svensson, Kristoffer, Dent, Jessica R, Tahvilian, Shahriar, Martins, Vitor F, Sathe, Abha, Ochala, Julien, Patel, Mulchand S, Schenk, Simon

“…The pyruvate dehydrogenase complex (PDC) converts pyruvate to acetyl-CoA and is an important control point for carbohydrate (CHO) oxidation. However, the…”
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Combined overexpression of SIRT1 and knockout of GCN5 in adult skeletal muscle does not affect glucose homeostasis or exercise performance in mice by Svensson, Kristoffer, Tahvilian, Shahriar, Martins, Vitor F, Dent, Jessica R, Lemanek, Adrianna, Barooni, Neeka, Greyslak, Keenan, McCurdy, Carrie E, Schenk, Simon

“…Sirtuin 1 (SIRT1) and general control of amino acid synthesis 5 (GCN5) regulate mitochondrial biogenesis via opposing modulation of peroxisome…”
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β‐Catenin is required for optimal exercise‐ and contraction‐stimulated skeletal muscle glucose uptake by Masson, Stewart W. C., Woodhead, Jonathan S. T., D'Souza, Randall F., Broome, Sophie C., MacRae, Caitlin, Cho, Hyun C., Atiola, Robert D., Futi, Tumanu, Dent, Jessica R., Shepherd, Peter R., Merry, Troy L.

“…Key points Loss of β‐catenin impairs in vivo and isolated muscle exercise/contraction‐stimulated glucose uptake. β‐Catenin is required for exercise‐induced…”
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Sirtuin 1 is not required for contraction-stimulated glucose uptake in mouse skeletal muscle by Kang, Ji Hyun, Park, Ji E, Dagoon, Jason, Masson, Stewart W C, Merry, Troy L, Bremner, Shannon N, Dent, Jessica R, Schenk, Simon

“…While it has long been known that contraction robustly stimulates skeletal muscle glucose uptake, the molecular steps regulating this increase remain…”
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Short inter‐set rest blunts resistance exercise‐induced increases in myofibrillar protein synthesis and intracellular signalling in young males by McKendry, James, Pérez‐López, Alberto, McLeod, Michael, Luo, Dan, Dent, Jessica R., Smeuninx, Benoit, Yu, Jinglei, Taylor, Angela E., Philp, Andrew, Breen, Leigh

“…New Findings What is the central question of this study? Does shorter rest between sets of resistance exercise promote a superior circulating hormonal and…”
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Skeletal muscle mitochondrial function and exercise capacity are not impaired in mice with knockout of STAT3 by Dent, Jessica R, Hetrick, Byron, Tahvilian, Shahriar, Sathe, Abha, Greyslak, Keenan, LaBarge, Samuel A, Svensson, Kristoffer, McCurdy, Carrie E, Schenk, Simon

“…Signal transducer and activator of transcription 3 (STAT3) was recently found to be localized to mitochondria in a number of tissues and cell types, where it…”
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Germline or inducible knockout of p300 or CBP in skeletal muscle does not alter insulin sensitivity by Martins, Vitor F, Dent, Jessica R, Svensson, Kristoffer, Tahvilian, Shahriar, Begur, Maedha, Lakkaraju, Shivani, Buckner, Elisa H, LaBarge, Samuel A, Hetrick, Byron, McCurdy, Carrie E, Schenk, Simon

“…Akt is a critical mediator of insulin-stimulated glucose uptake in skeletal muscle. The acetyltransferases, E1A binding protein p300 (p300) and cAMP response…”
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Protein‐carbohydrate ingestion alters Vps34 cellular localization independent of changes in kinase activity in human skeletal muscle by Hodson, Nathan, Dent, Jessica R., Song, Zhe, O'Leary, Mary F., Nicholson, Thomas, Jones, Simon W., Murray, James T., Jeromson, Stewart, Hamilton, D. Lee, Breen, Leigh, Philp, Andrew

“…New Findings What is the central question of the study? Is Vps34 a nutrient‐sensitive activator of mTORC1 in human skeletal muscle? What is the main finding…”
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Sex differences in acute translational repressor 4E-BP1 activity and sprint performance in response to repeated-sprint exercise in team sport athletes by Dent, Jessica R, Edge, Johann A, Hawke, Emma, McMahon, Christopher, Mündel, Toby

“…Abstract Objectives The physiological requirements underlying soccer-specific exercise are incomplete and sex-based comparisons are sparse. The aim of this…”
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Evidence for a Non-Genomic Action of Testosterone in Skeletal Muscle Which may Improve Athletic Performance: Implications for the Female Athlete by Dent, Jessica R, Fletcher, Deborah K, McGuigan, Michael R

“…This review will focus on the proposed second mode of testosterone action (now termed non-genomic) that appears to occur independently of the traditional…”
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Interleukin-6 is a negative regulator of hepatic glucose production in the isolated rat liver by Dent, Jessica R., Chowdhury, Md. Kamrul H., Tchijov, Sergei, Dulson, Deborah, Smith, Greg

“…The mechanism underlying the increased rate of endogenous glucose production from the liver during exercise remains unknown. The cytokine interleukin-6 (IL-6)…”
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The Effect of Exhaustive Exercise, Carbohydrate Ingestion and Muscle Glycogen Content on Exercise‐Induced Circulatory Immune Responses by Dent, Jessica R, Ogden, Henry, Hazeldine, Jon, Stocks, Ben, Zemp, Martina, Harrison, Paul, Philp, Andrew

“…Abstract only Exercising in a state of reduced muscle glycogen content (“compete‐high, train‐low”) enhances metabolic adaptation in skeletal muscle. However,…”
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The Effect of Graded Skeletal Muscle Glycogen Depletion on Whole‐body and Skeletal Muscle Metabolic Regulation by Dent, Jessica R, Stocks, Ben, Ogden, Henry, Zemp, Martina, Philp, Andrew

“…Abstract only Exercise training repeatedly exposes skeletal muscle to cyclical periods of glycogen depletion and re‐synthesis. There is evidence to suggest…”
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