Search Results - "Dent, Gordon"

The Contribution of Interleukin (IL)-4 and IL-13 to the Epithelial-Mesenchymal Trophic Unit in Asthma by Richter, Audrey, Puddicombe, Sarah M, Lordan, James L, Bucchieri, Fabio, Wilson, Susan J, Djukanovic', Ratko, Dent, Gordon, Holgate, Stephen T, Davies, Donna E

“…Interleukin (IL)-4 and IL-13 are key proinflammatory cytokines in asthma. Studies in transgenic mice show that both cytokines cause inflammation, but only…”
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The effect of selective and non‐selective phosphodiesterase inhibitors on allergen‐ and leukotriene C4‐induced contractions in passively sensitized human airways by Schmidt, Dunja T, Watson, Nikki, Dent, Gordon, Rühlmann, Elke, Branscheid, Detlev, Magnussen, Helgo, Rabe, Klaus F

“…Non‐selective inhibitors of cyclic nucleotide phosphodiesterase (PDE) block allergen‐induced contraction of passively sensitized human airways in vitro by a…”
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Evidence regarding the utility of multiple mini-interview (MMI) for selection to undergraduate health programs: A BEME systematic review: BEME Guide No. 37 by Rees, Eliot L., Hawarden, Ashley W., Dent, Gordon, Hays, Richard, Bates, Joanna, Hassell, Andrew B.

“…Background: In the 11 years since its development at McMaster University Medical School, the multiple mini-interview (MMI) has become a popular selection tool…”
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Inhibition of eosinophil cyclic nucleotide PDE activity and opsonised zymosan‐stimulated respiratory burst by ‘type IV’‐selective PDE inhibitors by Dent, Gordon, Giembycz, Mark A., Rabe, Klaus F., Barnes, Peter J.

“…1 The cyclic nucleotide phosphodiesterase (PDE) of guinea‐pig eosinophils was partially characterized and the effects of selective inhibitors of PDE isoenzymes…”
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Involvement of the α/β Isoform of p38 MAP Kinase in Chemotactic Responses of Human Eosinophils to Eotaxin (CCL11) and RANTES (CCL5) by Hasan, Anwar M, Dent, Gordon

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Protein Kinase C Inhibition Enhances Platelet-activating Factor-induced Eicosanoid Production in Human Eosinophils by Dent, Gordon, Munoz, Nilda M, Ruhlmann, Elke, Zhu, Xiangdong, Leff, Alan R, Magnussen, Helgo, Rabe, Klaus F

“…Previous investigations have suggested that protein kinase C (PKC) may regulate guinea pig eosinophil responses through a suppressive "negative feedback"…”
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Prosurvival activity for airway neutrophils in severe asthma by Uddin, Mohib, Nong, Guangmin, Ward, Jonathan, Seumois, Grégory, Prince, Lynne R, Wilson, Susan J, Cornelius, Victoria, Dent, Gordon, Djukanovic, Ratko

“…Airway neutrophilia is a recognised feature of chronic severe asthma, but the mechanisms that underlie this phenomenon are unknown. Evidence for factors…”
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Synergic production of neutrophil chemotactic activity by colonic epithelial cells and eosinophils by Dent, Gordon, Loweth, Sam C, Hasan, Anwar Matar, Leslie, Fiona M

“…Abstract The presence of eosinophils in the lumen and mucosa of the intestine is characteristic of both ulcerative colitis (UC) and Crohn's disease (CD). There…”
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The effect of selective and non‐selective phosphodiesterase inhibitors on allergen‐ and leukotriene C 4 ‐induced contractions in passively sensitized human airways by Schmidt, Dunja T, Watson, Nikki, Dent, Gordon, Rühlmann, Elke, Branscheid, Detlev, Magnussen, Helgo, Rabe, Klaus F

“…Non‐selective inhibitors of cyclic nucleotide phosphodiesterase (PDE) block allergen‐induced contraction of passively sensitized human airways in vitro by a…”
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Eosinophil chemotaxis by Dent, Gordon

“…Chemotaxis assays have a number of applications in the study of leukocyte biology and immune/inflammatory pathology. Multiwell "blind chamber"-type assays…”
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Impaired Neutrophil Chemotaxis in Chronic Obstructive Pulmonary Disease by Yoshikawa, Takahiro, Dent, Gordon, Ward, Jon, Angco, Gilbert, Nong, Guangmin, Nomura, Naho, Hirata, Kazuto, Djukanovic, Ratko

“…Neutrophilic airway inflammation is considered to be a major factor in the pathogenesis of chronic obstructive pulmonary disease (COPD), with sputum and…”
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Augmentation of human neutrophil and alveolar macrophage LTB 4 production by N ‐acetylcysteine: role of hydrogen peroxide by Dent, Gordon, Rabe, Klaus F., Magnussen, Helgo

“…The actions of N ‐acetylcysteine (NAC) on hydrogen peroxide (H 2 O 2 ) and leukotriene B 4 (LTB 4 ) production by human resting and stimulated peripheral blood…”
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Protein kinase A-independent responses to [beta]-adrenoceptor agonists by Dent, Gordon

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Radioligand binding of antagonists of platelet-activating factor to intact human platelets by Ukena, Dieter, Dent, Gordon, Birke, Frank W., Robaut, Christine, Sybrecht, Gerhard W., Barnes, Peter J.

“…Two new antagonists of platelet-activating factor (PAF), the pyrrolothiazole derivative 52770 RP and the triazolodiazepine WEB 2086, have been studied as…”
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Phosphoinositide 3-kinase γ mediates chemotactic responses of human eosinophils to platelet-activating factor by Hasan, Anwar Matar, Mourtada-Maarabouni, Mirna, Hameed, Mohammed S., Williams, Gwyn T., Dent, Gordon

“…Eosinophils are characteristic participants in allergic inflammation. The intracellular signalling mechanisms involved in the migration of eosinophils to sites…”
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Effect of a Paf antagonist, WEB 2086, on airway microvascular leakage in the guinea‐pig and platelet aggregation in man by Evans, Timothy W., Dent, Gordon, Rogers, Duncan F., Aursudkij, Boonrut, Chung, K. Fan, Barnes, Peter J.

“…1 The triazolodiazepine WEB 2086 has been evaluated as an antagonist of platelet‐activating factor (Paf) by studying its effects on Paf‐induced human platelet…”
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Phosphoinositide 3-kinase g mediates chemotactic responses of human eosinophils to platelet-activating factor by Hasan, Anwar Matar, Mourtada-Maarabouni, Mirna, Hameed, Mohammed S, Williams, Gwyn T, Dent, Gordon

“…Eosinophils are characteristic participants in allergic inflammation. The intracellular signalling mechanisms involved in the migration of eosinophils to sites…”
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The effect of anion transport inhibitors and extracellular Cl- concentration on eosinophil respiratory burst activity by Perkins, R S, Dent, G, Chung, K F, Barnes, P J

“…Furosemide has been shown recently to protect asthmatic patients against certain bronchoconstrictor challenges. We investigated the effect of furosemide on…”
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Contribution of Eotaxin-1 to Eosinophil Chemotactic Activity of Moderate and Severe Asthmatic Sputum by Dent, Gordon, Hadjicharalambous, Chrystalleni, Yoshikawa, Takahiro, Handy, Rachel L. C, Powell, John, Anderson, Ian K, Louis, Renaud, Davies, Donna E, Djukanovic, Ratko

“…The CC chemokine eotaxin-1 (CCL11) is chemotactic for eosinophils, basophils, and type 2 helper T cells and may play a role in allergic inflammation. We…”
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Protein kinase A‐independent responses to β‐adrenoceptor agonists by Dent, Gordon

“…British Journal of Pharmacology (2001) 133, 1199–1200; doi:10.1038/sj.bjp.0704214…”
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