Search Results - "Denson, L"

Versatile functions for IL-6 in metabolism and cancer by Mauer, Jan, Denson, Jesse L, Brüning, Jens C

“…Highlights • IL-6 has varied roles and its effects are highly context- and tissue-dependent. • IL-6 is largely beneficial for tissue homeostasis, with roles in…”
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Sex differences in determinants of COVID-19 severe outcomes – findings from the National COVID Cohort Collaborative (N3C) by Yoshida, Yilin, Chu, San, Fox, Sarah, Zu, Yuanhao, Lovre, Dragana, Denson, Joshua L, Miele, Lucio, Mauvais-Jarvis, Franck

“…Abstract Objective The impact of comorbidities and biomarkers on COVID-19 severity vary by sex but have not yet been verified in population-based studies. We…”
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Increased Mortality Rates During Resident Handoff Periods and the Effect of ACGME Duty Hour Regulations by Denson, Joshua L., MD, McCarty, Matthew, MD, Fang, Yixin, PhD, Uppal, Amit, MD, Evans, Laura, MD, MSc

“…Abstract Background Medical errors occur following handoff-related miscommunication. Data regarding the effect on patient-centered outcomes, specifically…”
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Death Cafés for prevention of burnout in intensive care unit employees: study protocol for a randomized controlled trial (STOPTHEBURN) by Bateman, Marjorie E, Hammer, Rachel, Byrne, Abigail, Ravindran, Nithya, Chiurco, Jennifer, Lasky, Sasha, Denson, Rebecca, Brown, Margo, Myers, Leann, Zu, Yuanhao, Denson, Joshua L

“…Burnout is an occupational syndrome that leads to mental health problems, job turnover, and patient safety events. Those caring for critically ill patients are…”
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Exacerbation-prone asthma in the context of race and ancestry in Asthma Clinical Research Network trials by Grossman, Nicole L., Ortega, Victor E., King, Tonya S., Bleecker, Eugene R., Ampleford, Elizabeth A., Bacharier, Leonard B., Cabana, Michael D., Cardet, Juan C., Carr, Tara F., Castro, Mario, Denlinger, Loren C., Denson, Joshua L., Fandino, Nicolas, Fitzpatrick, Anne M., Hawkins, Gregory A., Holguin, Fernando, Krishnan, Jerry A., Lazarus, Stephen C., Nyenhuis, Sharmilee M., Phipatanakul, Wanda, Ramratnam, Sima K., Wenzel, Sally, Peters, Stephen P., Meyers, Deborah A., Wechsler, Michael E., Israel, Elliot

“…Minority groups of African descent experience disproportionately greater asthma morbidity compared with other racial groups, suggesting that genetic variation…”
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Clinical characteristics and outcomes in women and men hospitalized for coronavirus disease 2019 in New Orleans by Yoshida, Yilin, Gillet, Scott A, Brown, Margo I, Zu, Yuanhao, Wilson, Sarah M, Ahmed, Sabreen J, Tirumalasetty, Saritha, Lovre, Dragana, Krousel-Wood, Marie, Denson, Joshua L, Mauvais-Jarvis, Franck

“…Determine if sex differences exist in clinical characteristics and outcomes of adults hospitalized for coronavirus disease 2019 (COVID-19) in a US healthcare…”
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A call for collaboration and consensus on training for endotracheal intubation in the medical intensive care unit by Brown, Wade, Santhosh, Lekshmi, Brady, Anna K, Denson, Joshua L, Niroula, Abesh, Pugh, Meredith E, Self, Wesley H, Joffe, Aaron M, O'Neal Maynord, P, Carlos, W Graham

“…Endotracheal intubation (EI) is a potentially lifesaving but high-risk procedure in critically ill patients. While the ACGME mandates that trainees in…”
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NOX1 loss-of-function genetic variants in patients with inflammatory bowel disease by Schwerd, T, Bryant, R V, Pandey, S, Capitani, M, Meran, L, Cazier, J-B, Jung, J, Mondal, K, Parkes, M, Mathew, C G, Fiedler, K, McCarthy, D J, Sullivan, P B, Rodrigues, A, Travis, S P L, Moore, C, Sambrook, J, Ouwehand, W H, Roberts, D J, Danesh, J, Russell, R K, Wilson, D C, Kelsen, J R, Cornall, R, Denson, L A, Kugathasan, S, Knaus, U G, Serra, E G, Anderson, C A, Duerr, R H, McGovern, D PB, Cho, J, Powrie, F, Li, V SW, Muise, A M, Uhlig, H H

“…Genetic defects that affect intestinal epithelial barrier function can present with very early-onset inflammatory bowel disease (VEOIBD). Using whole-genome…”
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Association Between Hypertension and Diabetes Control and COVID-19 Severity: National Patient-Centered Clinical Research Network, United States, March 2020 to February 2022 by Jackson, Sandra L, Woodruff, Rebecca C, Nagavedu, Kshema, Fearrington, Julia, Rolka, Deborah B, Twentyman, Evelyn, Carton, Thomas W, Puro, Jon, Denson, Joshua L, Kappelman, Michael D, Paranjape, Anuradha, Thacker, Deepika, Weiner, Mark G, Goodman, Alyson B, Lekiachvili, Akaki, Boehmer, Tegan K, Block, Jason P

“…Background Hypertension and diabetes are associated with increased COVID-19 severity. The association between level of control of these conditions and COVID-19…”
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Pulmonary delivery of the broad-spectrum matrix metalloproteinase inhibitor marimastat diminishes multiwalled carbon nanotube-induced circulating bioactivity without reducing pulmonary inflammation by Young, Tamara L, Mostovenko, Ekaterina, Denson, Jesse L, Begay, Jessica G, Lucas, Selita N, Herbert, Guy, Zychowski, Katherine, Hunter, Russell, Salazar, Raul, Wang, Ting, Fraser, Kelly, Erdely, Aaron, Ottens, Andrew K, Campen, Matthew J

“…Multiwalled carbon nanotubes (MWCNT) are an increasingly utilized engineered nanomaterial that pose the potential for significant risk of exposure-related…”
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Regulation of intestinal barrier function by signal transducer and activator of transcription 5b by Han, X, Ren, X, Jurickova, I, Groschwitz, K, Pasternak, B A, Xu, H, Wilson, T A, Hogan, S P, Denson, L A

“…Colon epithelial cell (CEC) apoptosis and nuclear factor-kappaB (NF-kappaB) activation may compromise barrier function, and it has been reported that signal…”
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A key requirement for CD300f in innate immune responses of eosinophils in colitis by Moshkovits, I, Reichman, H, Karo-Atar, D, Rozenberg, P, Zigmond, E, Haberman, Y, Ben Baruch-Morgenstern, N, Lampinen, M, Carlson, M, Itan, M, Denson, L A, Varol, C, Munitz, A

“…Eosinophils are traditionally studied in the context of type 2 immune responses. However, recent studies highlight key innate immune functions for eosinophils…”
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Paediatric Crohn disease patients with stricturing behaviour exhibit ileal granulocyte–macrophage colony‐stimulating factor (GM‐CSF) autoantibody production and reduced neutrophil bacterial killing and GM‐CSF bioactivity by Jurickova, I., Collins, M. H., Chalk, C., Seese, A., Bezold, R., Lake, K., Allmen, D., Frischer, J. S., Falcone, R. A., Trapnell, B. C., Denson, L. A.

“…Summary Granulocyte–macrophage colony‐stimulating factor (GM‐CSF) autoantibodies are associated with stricturing behaviour in Crohn disease (CD). We…”
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Psychosocial Outcomes of Telephone-Based Counseling for Adults With an Acquired Physical Disability: A Meta-Analysis by Dorstyn, D. S, Mathias, J. L, Denson, L. A

“…Background: The delivery of mental health services by telephone, referred to as telecounseling, has the potential to improve the health outcomes of adults with…”
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Prenatal Hypoxia-Ischemia Induces Abnormalities in CA3 Microstructure, Potassium Chloride Co-Transporter 2 Expression and Inhibitory Tone by Jantzie, Lauren L, Getsy, Paulina M, Denson, Jesse L, Firl, Daniel J, Maxwell, Jessie R, Rogers, Danny A, Wilson, Christopher G, Robinson, Shenandoah

“…Infants who suffer perinatal brain injury, including those with encephalopathy of prematurity, are prone to chronic neurological deficits, including epilepsy,…”
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Changing Paradigms in the Treatment of Severe Asthma: The Role of Biologic Therapies by Katial, Rohit K., MD, Bensch, Greg W., MD, Busse, William W., MD, Chipps, Bradley E., MD, Denson, Joshua L., MD, Gerber, Anthony N., MD, PhD, Jacobs, Joshua S., MD, Kraft, Monica, MD, Martin, Richard J., MD, Nair, Parameswaran, MD, PhD, FRCP, FRCPC, Wechsler, Michael E., MD

“…Cytokine antagonists are monoclonal antibodies that offer new treatment options for refractory asthma but will also increase complexity because they are…”
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Psychological intervention during spinal rehabilitation: a preliminary study by Dorstyn, D S, Mathias, J L, Denson, L A

“…Study design: A repeated measures, non-randomised controlled trial. Objective: To examine the effectiveness of individualised cognitive behaviour therapy (CBT)…”
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Therapeutic Hypothermia After Cardiac Arrest in a Patient With Systemic Sclerosis and Raynaud Phenomenon by Bakal, Keren, MD, Danckers, Mauricio, MD, Denson, Joshua L., MD, Sauthoff, Harald, MD

“…Therapeutic hypothermia favorably impacts neurologic outcomes in patients after cardiopulmonary arrest, although the appropriate target temperature is less…”
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COVID-19 Outcomes Stratified by Control Status of Hypertension and Diabetes: Preliminary Findings From PCORnet, U.S by Jackson, Sandra L., Block, Jason P., Rolka, Deborah B., Pavkov, Meda E., Chevinsky, Jennifer R., Lekiachvili, Akaki, Carton, Thomas W., Thacker, Deepika, Denson, Joshua L., Paranjape, Anuradha, Kappelman, Michael D., Boehmer, Tegan K., Twentyman, Evelyn

“…•Among 656,049 adults with COVID-19, 41% had hypertension, and 13% had diabetes.•Approximately one quarter of those with hypertension had blood pressure…”
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SWEAT ICU-An Observational Study of Physician Workload and the Association of Physician Outcomes in Academic ICUs by Agarwal, Ankita, Chen, Jen-Ting, Coopersmith, Craig M, Denson, Joshua L, Dickert, Neal W, Ferrante, Lauren E, Gershengorn, Hayley B, Gosine, Adhiraj D, Hayward, Bradley J, Kaur, Navneet, Khan, Akram, Lamberton, Courtney, Landsittel, Douglas, Lyons, Patrick G, Mikkelsen, Mark E, Nadig, Nandita R, Pietropaoli, Anthony P, Poole, Brian R, Viglianti, Elizabeth M, Sevransky, Jonathan E

“…The optimal staffing model for physicians in the ICU is unknown. Patient-to-intensivist ratios may offer a simple measure of workload and be associated with…”
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