Search Results - "Denny, William A."

Nitroaromatic Hypoxia-Activated Prodrugs for Cancer Therapy by Denny, William A

“…The presence of "hypoxic" tissue (with O levels of <0.1 mmHg) in solid tumours, resulting in quiescent tumour cells distant from blood vessels, but capable of…”
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Cyclic Tetrapeptides from Nature and Design: A Review of Synthetic Methodologies, Structure, and Function by Sarojini, Vijayalekshmi, Cameron, Alan J, Varnava, Kyriakos G, Denny, William A, Sanjayan, Gangadhar

“…Small cyclic peptides possess a wide range of biological properties and unique structures that make them attractive to scientists working in a range of areas…”
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A Selective and Slowly Reversible Inhibitor of l‑Type Amino Acid Transporter 1 (LAT1) Potentiates Antiproliferative Drug Efficacy in Cancer Cells by Huttunen, Kristiina M, Gynther, Mikko, Huttunen, Johanna, Puris, Elena, Spicer, Julie A, Denny, William A

“…The l-type amino acid transporter 1 (LAT1) is a transmembrane protein carrying bulky and neutral amino acids into cells. LAT1 is overexpressed in several types…”
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Effect of wet milling process on the solid state of indomethacin and simvastatin by Sharma, Puneet, Denny, William A., Garg, Sanjay

“…The aim of this study was to investigate the effect of wet milling on the solid state of indomethacin (IMC) and simvastatin (SIM). Wet milling was performed…”
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Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality by Chan, Denise A, Sutphin, Patrick D, Nguyen, Phuong, Turcotte, Sandra, Lai, Edwin W, Banh, Alice, Reynolds, Gloria E, Chi, Jen-Tsan, Wu, Jason, Solow-Cordero, David E, Bonnet, Muriel, Flanagan, Jack U, Bouley, Donna M, Graves, Edward E, Denny, William A, Hay, Michael P, Giaccia, Amato J

“…Identifying new targeted therapies that kill tumor cells while sparing normal tissue is a major challenge of cancer research. Using a high-throughput chemical…”
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Genotoxicity of non-covalent interactions: DNA intercalators by Ferguson, Lynnette R, Denny, William A

“…This review provides an update on the mutagenicity of intercalating chemicals, as carried out over the last 17 years. The most extensively studied DNA…”
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Inhibitors of Discoidin Domain Receptor (DDR) Kinases for Cancer and Inflammation by Denny, William A, Flanagan, Jack U

“…The discoidin domain receptor tyrosine kinases DDR1 and DDR2 are distinguished from other kinase enzymes by their extracellular domains, which interact with…”
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Inhibition of strigolactone receptors by N-phenylanthranilic acid derivatives: Structural and functional insights by Hamiaux, Cyril, Drummond, Revel S.M., Luo, Zhiwei, Lee, Hui Wen, Sharma, Prachi, Janssen, Bart J., Perry, Nigel B., Denny, William A., Snowden, Kimberley C.

“…The strigolactone (SL) family of plant hormones regulates a broad range of physiological processes affecting plant growth and development and also plays…”
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A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types by Jamieson, Stephen, Flanagan, Jack U, Kolekar, Sharada, Buchanan, Christina, Kendall, Jackie D, Lee, Woo-Jeong, Rewcastle, Gordon W, Denny, William A, Singh, Ripudaman, Dickson, James, Baguley, Bruce C, Shepherd, Peter R

“…Genetic alterations in PI3K (phosphoinositide 3-kinase) signalling are common in cancer and include deletions in PTEN (phosphatase and tensin homologue deleted…”
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The Use of Heptamethine Cyanine Dyes as Drug-Conjugate Systems in the Treatment of Primary and Metastatic Brain Tumors by Cooper, Elizabeth, Choi, Peter J., Denny, William A., Jose, Jiney, Dragunow, Mike, Park, Thomas I.-H.

“…Effective cancer therapeutics for brain tumors must be able to cross the blood-brain barrier (BBB) to reach the tumor in adequate quantities and overcome the…”
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Systemic and Brain Pharmacokinetics of Perforin Inhibitor Prodrugs by Gynther, Mikko, Pickering, Darryl S, Spicer, Julie A, Denny, William A, Huttunen, Kristiina M

“…We have recently reported that by converting a perforin inhibitor into an l-type amino acid transporter 1 (LAT1)-utilizing prodrug its cellular uptake can be…”
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Synergistic Activity of Nitroimidazole-Oxazolidinone Conjugates against Anaerobic Bacteria by Zhuang, Zhijun, Wan, Dawei, Ding, Jun, He, Shijie, Zhang, Qian, Wang, Xiaomei, Yuan, Ying, Lu, Yu, Ding, Charles Z, Lynch, Anthony Simon, Upton, Anna M, Cooper, Christopher B, Denny, William A, Ma, Zhenkun

“…The introductions of the bicyclic 4-nitroimidazole and the oxazolidinone classes of antimicrobial agents represented the most significant advancements in the…”
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Structure-Activity Relationships for the Anaesthetic and Analgaesic Properties of Aromatic Ring-Substituted Ketamine Esters by Dimitrov, Ivaylo V, Harvey, Martyn G, Voss, Logan J, Sleigh, James W, Bickerdike, Michael J, Denny, William A

“…A series of benzene ring substituted ketamine -alkyl esters were prepared from the corresponding substituted norketamines. Few of the latter have been reported…”
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Synthetic Studies to Help Elucidate the Metabolism of the Preclinical Candidate TBAJ-876-A Less Toxic and More Potent Analogue of Bedaquiline by Choi, Peter J, Conole, Daniel, Sutherland, Hamish S, Blaser, Adrian, Tong, Amy S T, Cooper, Christopher B, Upton, Anna M, Palmer, Brian D, Denny, William A

“…Bedaquiline is a novel drug approved in 2012 by the FDA for treatment of drug-resistant tuberculosis (TB). Although it shows high efficacy towards…”
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Pharmacokinetic/Pharmacodynamic Modeling Identifies SN30000 and SN29751 as Tirapazamine Analogues with Improved Tissue Penetration and Hypoxic Cell Killing in Tumors by HICKS, Kevin O, SIIM, Bronwyn G, DENNY, William A, HAY, Michael P, WILSON, William R, JAISWAL, Jagdish K, PRUIJN, Frederik B, FRASER, Annie M, PATEL, Rita, HOGG, Alison, SARATH LIYANAGE, H. D, JO DORIE, Mary, BROWN, J. Martin

“…Tirapazamine (TPZ) has attractive features for targeting hypoxic cells in tumors but has limited clinical activity, in part because of poor extravascular…”
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Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling by Chaussade, Claire, Rewcastle, Gordon W, Kendall, Jackie D, Denny, William A, Cho, Kitty, Grønning, Line M, Chong, Mei Ling, Anagnostou, Sasha H, Jackson, Shaun P, Daniele, Nathalie, Shepherd, Peter R

“…Recent genetic knock-in and pharmacological approaches have suggested that, of class IA PI3Ks (phosphatidylinositol 3-kinases), it is the p110alpha isoform…”
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Mechanism of Action and Preclinical Antitumor Activity of the Novel Hypoxia-Activated DNA Cross-Linking Agent PR-104 by PATTERSON, Adam V, FERRY, Dianne M, SHANGJIN YANG, DENNY, William A, WILSON, William R, EDMUNDS, Shelley J, YONGCHUAN GU, SINGLETON, Rachelle S, PATEL, Kashyap, PULLEN, Susan M, HICKS, Kevin O, SYDDALL, Sophie P, ATWELL, Graham J

“…Purpose: Hypoxia is a characteristic of solid tumors and a potentially important therapeutic target. Here, we characterize the mechanism of action and…”
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Involvement of the tumour necrosis factor receptor system in glioblastoma cell death induced by palbociclib-heptamethine cyanine dye conjugate by Cooper, Elizabeth, Oyagawa, Caitlin R M, Johnson, Rebecca, Choi, Peter J, Foliaki, Jena Macapagal, Correia, Jason, Schweder, Patrick, Heppner, Peter, Mee, Edward, Turner, Clinton, Faull, Richard, Denny, William A, Dragunow, Mike, Jose, Jiney, Park, Thomas I-H

“…Glioblastoma is the most common and aggressive primary brain tumour in adults. The development of anti-brain cancer agents are challenged by the blood-brain…”
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Transcriptional changes in response to ketamine ester-analogs SN 35210 and SN 35563 in the rat brain by Jacobson, Gregory M, Voss, Logan J, Klockars, Anica, Bird, Steve, Dimitrov, Ivo, Denny, William A, Olszewski, Pawel K, Sleigh, James W, Harvey, Martyn G

“…Ketamine ester analogs, SN 35210 and SN 35563, demonstrate different pharmacological profiles to ketamine in animal models. Both confer hypnosis with…”
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Evaluation of a crystalline nanosuspension: Polymorphism, process induced transformation and in vivo studies by Sharma, Puneet, Zujovic, Zoran D., Bowmaker, Graham A., Denny, William A., Garg, Sanjay

“…The aim of this work was to evaluate a crystalline nanosuspension of an investigational anticancer compound, SN 30191. Solid forms of SN 30191 were prepared…”
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