Search Results - "Dennis Hall, C."

Peptidomimetics via modifications of amino acids and peptide bonds by Avan, Ilker, Hall, C Dennis, Katritzky, Alan R

“…Peptidomimetics represent an important field in chemistry, pharmacology and material science as they circumvent the limitations of traditional peptides used in…”
Get more information

Tautomerism in drug discovery by Katritzky, Alan R., Hall, C. Dennis, El-Gendy, Bahaa El-Dien M., Draghici, Bogdan

“…The influence of tautomerism on the precise structure of drugs and thus of their potential to interact with biological systems is discussed from thermodynamic…”
Get full text

Synthesis and bioassay of improved mosquito repellents predicted from chemical structure by Katritzky, Alan R, Wang, Zuoquan, Slavov, Svetoslav, Tsikolia, Maia, Dobchev, Dimitar, Akhmedov, Novruz G, Hall, C. Dennis, Bernier, Ulrich R, Clark, Gary G, Linthicum, Kenneth J

“…Mosquito repellency data on acylpiperidines derived from the U.S. Department of Agriculture archives were modeled by using molecular descriptors calculated by…”
Get full text

Cu(I)-Catalyzed Regioselective Synthesis of Pyrazolo[5,1-c]-1,2,4-triazoles by Jishkariani, Davit, Hall, C. Dennis, Oliferenko, Alexander A, Leino, David, Katritzky, Alan R

“…Cycloadditions of terminal alkynes to 1,2,4-triazolium N-imides in the presence of base and Cu(I) afford pyrazolo[5,1-c]-1,2,4-triazoles regioselectively. The…”
Get full text

Push-Pull Triazenes Derived from 1‑(Benzylideneamino)- and 1‑(Sulfonimido)-azolylidenes by Jishkariani, Davit, Hall, C. Dennis, Demircan, Aydin, Tomlin, Blake J, Steel, Peter J, Katritzky, Alan R

“…In-situ-generated neutral 1-(benzylideneamino)- and novel anionic 1-(sulfonimido)-azolylidenes react with organic azides to afford diverse classes of push-pull…”
Get full text

NMR Study of the Tautomeric Behavior of N-(α-Aminoalkyl)tetrazoles by Katritzky, Alan R, El-Gendy, Bahaa El-Dien M, Draghici, Bogdan, Hall, C. Dennis, Steel, Peter J

“…N-(α-Aminoalkyl)tetrazoles exist in solution as equilibrium mixtures of N1 and N2 tautomers. The position of equilibrium depends significantly on the polarity…”
Get full text

Synthesis and bioactivity of a Goralatide analog with antileukemic activity by Li, Zhiliang, Lebedyeva, Iryna O., Golubovskaya, Vita M., Cance, William G., Alamry, Khalid A., Faidallah, Hassan M., Dennis Hall, C., Katritzky, Alan R.

“…[Display omitted] Natural tetrapeptide Goralatide (AcSDKP) is a selective inhibitor of primitive haematopoietic cell proliferation. It is not stable in vivo…”
Get full text

Quantitative Correlation of Physical and Chemical Properties with Chemical Structure: Utility for Prediction by Katritzky, Alan R, Kuanar, Minati, Slavov, Svetoslav, Hall, C. Dennis, Karelson, Mati, Kahn, Iiris, Dobchev, Dimitar A

“…Quantitative relationships between chemical properties and molecular structure, and the methods used to examine them, are discussed. Their utility in…”
Get full text

Quinine conjugates and quinine analogues as potential antimalarial agents by Jones, Rachel A., Panda, Siva S., Hall, C. Dennis

“…Malaria is a tropical disease, prevalent in Southeast Asia and Africa, resulting in over half a million deaths annually; efforts to develop new antimalarial…”
Get full text

Novel antibacterial active quinolone–fluoroquinolone conjugates and 2D-QSAR studies by Panda, Siva S., Liaqat, Sumaira, Girgis, Adel S., Samir, Ahmed, Hall, C. Dennis, Katritzky, Alan R.

“…[Display omitted] Novel, quinolone–fluoroquinolone conjugates 10a–f, 11a–f, 13a–f and 14a–f with amino acid linkers were synthesized in good yields utilizing…”
Get full text

Applications of Chemical Ligation in Peptide Synthesis via Acyl Transfer by Panda, Siva S, Jones, Rachel A, Hall, C Dennis, Katritzky, Alan R

“…The utility of native chemical ligation (NCL) in the solution or solid phase synthesis of peptides, cyclic peptides, glycopeptides, and neoglycoconjugates is…”
Get more information

Facile Syntheses of 2,2-Dimethyl-6-(2-oxoalkyl)-1,3-dioxin-4-ones and the Corresponding 6-Substituted 4-Hydroxy-2-pyrones by Katritzky, Alan R, Wang, Zuoquan, Wang, Mingyi, Hall, C. Dennis, Suzuki, Kazuyuki

“…A variety of 2,2-dimethyl-6-(2-oxoalkyl)-1,3-dioxin-4-ones 5a− l and the corresponding 6-substituted 4-hydroxy-2-pyrones 3a− l were prepared in high yields…”
Get full text

NMR spectra, GIAO and charge density calculations of five-membered aromatic heterocycles by Katritzky, Alan R., Akhmedov, Novruz G., Doskocz, Jacek, Mohapatra, Prabhu P., Hall, C. Dennis, Güven, Alâattin

“…The B3LYP/6‐31 + G(d) molecular geometry optimized structures of 17 five‐membered heterocycles were employed together with the gauge including atomic orbitals…”
Get full text

Interactions of DEET and Novel Repellents With Mosquito Odorant Receptors by Grant, Gariel G., Estrera, Rachel R., Pathak, Narendra, Hall, C. Dennis, Tsikolia, Maia, Linthicum, Kenneth J., Bernier, Ulrich R., Hall, Adam C.

“…The carboxamide N, N-di-ethyl-meta-toluamide (DEET) is the most effective and widely used insect repellent today. However, drawbacks concerning the efficacy…”
Get full text

Molecular docking‐guided synthesis of NSAID–glucosamine bioconjugates and their evaluation as COX‐1/COX‐2 inhibitors with potentially reduced gastric toxicity by Jones Lipinski, Rachel A., Thillier, Yann, Morisseau, Christophe, Sebastiano, Christopher S., Smith, Brian C., Hall, C. Dennis, Katritzky, Alan R.

“…Non‐steroidal anti‐inflammatory drugs (NSAIDs) are a powerful class of inhibitors targeting two isoforms of the family of cyclooxygenase enzymes (COX‐1 and…”
Get full text

Traceless Chemical Ligation from S‑, O‑, and N‑Acyl Isopeptides by Panda, Siva S, Hall, C. Dennis, Oliferenko, Alexander A, Katritzky, Alan R

“…Peptides are ubiquitous in nature where they play crucial roles as catalysts (enzymes), cell membrane ion transporters, and structural elements (proteins)…”
Get full text

Synthesis, characterization and energetic properties of novel 1-methyl-1,2,4-triazolium N-aryl/N-pyridinyl ylids by Zhang, Hong, Wang, Zuoquan, Ghiviriga, Ion, Pillai, Girinath G., Jabeen, Farukh, Arami, Justin A., Zhou, Wenfeng, Steel, Peter J., Dennis Hall, C., Katritzky, Alan R.

“…[Display omitted] •Synthesis of thirteen novel 1,2,4-triazolium ylids.•Characterization by elemental analysis, mass spectrometry and 1H, 13C and 15N NMR.•X-ray…”
Get full text

Dual inhibition of the α-glucosidase and butyrylcholinesterase studied by Molecular Field Topology Analysis by Jabeen, Farukh, Oliferenko, Polina V., Oliferenko, Alexander A., Pillai, Girinath G., Ansari, Farzana Latif, Hall, C. Dennis, Katritzky, Alan R.

“…A striking dual inhibition of enzymes α-glucosidase and butyrylcholinesterase by small drug-like molecules, including 1,4-disubstituted-1,2,3-triazoles,…”
Get full text

Synthesis, and QSAR analysis of anti-oncological active spiro-alkaloids by Girgis, Adel S, Panda, Siva S, Farag, I S Ahmed, El-Shabiny, A M, Moustafa, A M, Ismail, Nasser S M, Pillai, Girinath G, Panda, Chandramukhi S, Hall, C Dennis, Katritzky, Alan R

“…QSAR study describes the anti-neoplastic spiro-alkaloids with relevant molecular descriptors using CODESSA III software. The…”
Get more information

Macrocyclic peptidomimetics with antimicrobial activity: synthesis, bioassay, and molecular modeling studies by Ibrahim, Mohamed A, Panda, Siva S, Oliferenko, Alexander A, Oliferenko, Polina V, Girgis, Adel S, Elagawany, Mohamed, Küçükbay, F Zehra, Panda, Chandramukhi S, Pillai, Girinath G, Samir, Ahmed, Tämm, Kaido, Hall, C Dennis, Katritzky, Alan R

“…Novel, cyclic peptidomimetics were synthesized by facile acylation reactions using benzotriazole chemistry. Microbiological testing of the synthesized…”
Get more information