Search Results - "Dennis E. Hruby"

Oral Tecovirimat for the Treatment of Smallpox by Grosenbach, Douglas W, Honeychurch, Kady, Rose, Eric A, Chinsangaram, Jarasvech, Frimm, Annie, Maiti, Biswajit, Lovejoy, Candace, Meara, Ingrid, Long, Paul, Hruby, Dennis E

“…There are no FDA-approved antiviral agents to treat infection with variola virus, the cause of smallpox. In this report, the efficacy of tecovirimat, a new…”
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Comparison of the safety and pharmacokinetics of ST-246® after i.v. infusion or oral administration in mice, rabbits and monkeys by Chen, Yali, Amantana, Adams, Tyavanagimatt, Shanthakumar R, Zima, Daniela, Yan, X Steven, Kasi, Gopi, Weeks, Morgan, Stone, Melialani A, Weimers, William C, Samuel, Peter, Tan, Ying, Jones, Kevin F, Lee, Daniel R, Kickner, Shirley S, Saville, Bradley M, Lauzon, Martin, McIntyre, Alan, Honeychurch, Kady M, Jordan, Robert, Hruby, Dennis E, Leeds, Janet M

“…ST-246® is an antiviral, orally bioavailable small molecule in clinical development for treatment of orthopoxvirus infections. An intravenous (i.v.)…”
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ST-246 is a key antiviral to inhibit the viral F13L phospholipase, one of the essential proteins for orthopoxvirus wrapping by Duraffour, Sophie, Lorenzo, María M, Zöller, Gudrun, Topalis, Dimitri, Grosenbach, Doug, Hruby, Dennis E, Andrei, Graciela, Blasco, Rafael, Meyer, Hermann, Snoeck, Robert

“…ST-246 is one of the key antivirals being developed to fight orthopoxvirus (OPV) infections. Its exact mode of action is not completely understood, but it has…”
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Overview of the regulatory approval of tecovirimat intravenous formulation for treatment of smallpox: potential impact on smallpox outbreak response capabilities, and future tecovirimat development potential by Russo, Andrew T, Grosenbach, Douglas W, Honeychurch, Kady M, Long, Paul G, Hruby, Dennis E

“…Tecovirimat oral capsule formulation is approved in the US and Canada for treatment of smallpox and in the United Kingdom (UK) and European Union (EU) for…”
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A Novel Inhibitor of Dengue Virus Replication That Targets the Capsid Protein by Byrd, Chelsea M, Dai, Dongcheng, Grosenbach, Douglas W, Berhanu, Aklile, Jones, Kevin F, Cardwell, Kara B, Schneider, Christine, Wineinger, Kristin A, Page, Jessica M, Harver, Chris, Stavale, Eric, Tyavanagimatt, Shanthakumar, Stone, Melialani A, Bartenschlager, Ralf, Scaturro, Pietro, Hruby, Dennis E, Jordan, Robert

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Smallpox lesion characterization in placebo-treated and tecovirimat-treated macaques using traditional and novel methods by Bell, Todd M, Facemire, Paul, Bearss, Jeremy J, Raymond, Jo Lynne, Chapman, Jennifer, Zeng, Xiankun, Shamblin, Joshua D, Williams, Janice A, Grosenbach, Douglas W, Hruby, Dennis E, Damon, Inger K, Goff, Arthur J, Mucker, Eric M

“…Smallpox was the most rampant infectious disease killer of the 20th century, yet much remains unknown about the pathogenesis of the variola virus. Using…”
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Efficacy of Tecovirimat (ST-246) in Nonhuman Primates Infected with Variola Virus (Smallpox) by MUCKER, Eric M, GOFF, Arthur J, CLEMMONS, Cody J, HUDSON, Paul, HRUBY, Dennis E, SHAMBLIN, Joshua D, GROSENBACH, Douglas W, DAMON, Inger K, MEHAL, Jason M, HOLMAN, Robert C, CARROLL, Darin, GALLARDO, Nadia, OLSON, Victoria A

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Novel Benzoxazole Inhibitor of Dengue Virus Replication That Targets the NS3 Helicase by BYRD, Chelsea M, GROSENBACH, Douglas W, WINEINGER, Kristin A, PAGE, Jessica, STAVALE, Eric, STONE, Melialani A, FULLER, Kathleen P, LOVEJOY, Candace, LEEDS, Janet M, HRUBY, Dennis E, JORDAN, Robert, BERHANU, Aklile, DONGCHENG DAI, JONES, Kevin F, CARDWELL, Kara B, SCHNEIDER, Christine, GUANG YANG, TYAVANAGIMATT, Shanthakumar, HARVER, Chris

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Identification of a Broad-Spectrum Arenavirus Entry Inhibitor by Larson, Ryan A, Dai, Dongcheng, Hosack, Virginia T, Tan, Ying, Bolken, Tove' C, Hruby, Dennis E, Amberg, Sean M

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Effective Antiviral Treatment of Systemic Orthopoxvirus Disease: ST-246 Treatment of Prairie Dogs Infected with Monkeypox Virus by SMITH, Scott K, SELF, Josh, WEISS, Sonja, CARROLL, Darin, BRADEN, Zach, REGNERY, Russell L, DAVIDSON, Whitni, JORDAN, Robert, HRUBY, Dennis E, DAMON, Inger K

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Development of ST-246® for Treatment of Poxvirus Infections by Jordan, Robert, Leeds, Janet M, Tyavanagimatt, Shanthakumar, Hruby, Dennis E

“…ST-246 (Tecovirimat) is a small synthetic antiviral compound being developed to treat pathogenic orthopoxvirus infections of humans. The compound was…”
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Synergistic Efficacy of the Combination of ST-246 with CMX001 against Orthopoxviruses by QUENELLE, Debra C, PRICHARD, Mark N, KEITH, Kathy A, HRUBY, Dennis E, JORDAN, Robert, PAINTER, George R, ROBERTSON, Alice, KERN, Earl R

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ST-246 Antiviral Efficacy in a Nonhuman Primate Monkeypox Model: Determination of the Minimal Effective Dose and Human Dose Justification by JORDAN, Robert, GOFF, Arthur, JOHNSON, Wendy, CHAPMAN, Jennifer, TWENHAFEL, Nancy, TYAVANAGIMATT, Shanthakumar, AMANTANA, Adams, CHINSANGARAM, Jarasvech, HRUBY, Dennis E, HUGGINS, John, FRIMM, Annie, CORRADO, Michael L, HENSLEY, Lisa E, BYRD, Chelsea M, MUCKER, Eric, SHAMBLIN, Josh, BOLKEN, Tove C, WLAZLOWSKI, Carly

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Efficacy of Delayed Treatment with ST-246 Given Orally against Systemic Orthopoxvirus Infections in Mice by QUENELLE, Debra C, BULLER, R. M. L, PARKER, Scott, KEITH, Kathy A, HRUBY, Dennis E, JORDAN, Robert, KERN, Earl R

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In Vitro Efficacy of ST246 against Smallpox and Monkeypox by SMITH, Scott K, OLSON, Victoria A, KAREM, Kevin L, JORDAN, Robert, HRUBY, Dennis E, DAMON, Inger K

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Safety and Pharmacokinetics of the Anti-Orthopoxvirus Compound ST-246 following a Single Daily Oral Dose for 14 Days in Human Volunteers by CHINSANGARAM, Jarasvech, HONEYCHURCH, Kady M, ROSS, Eric, LICHTENSTEIN, Israel, PICKENS, Margaret, CORRADO, Michael, CLARKE, Jean M, FRIMM, Annie M, HRUBY, Dennis E, TYAVANAGIMATT, Shanthakumar R, LEEDS, Janet M, BOLKEN, Tove' C, JONES, Kevin F, JORDAN, Robert, MARBURY, Thomas, RUCKLE, Jon, MEE-LEE, Denis

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Evaluation of Lassa antiviral compound ST-193 in a guinea pig model by Cashman, Kathleen A., Smith, Mark A., Twenhafel, Nancy A., Larson, Ryan A., Jones, Kevin F., Allen, Robert D., Dai, Dongcheng, Chinsangaram, Jarasvech, Bolken, Tove’ C., Hruby, Dennis E., Amberg, Sean M., Hensley, Lisa E., Guttieri, Mary C.

“…Lassa virus (LASV), a member of the Arenaviridae family, causes a viral hemorrhagic fever endemic to West Africa, where as many as 300,000 infections occur per…”
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ST-246 Inhibits In Vivo Poxvirus Dissemination, Virus Shedding, and Systemic Disease Manifestation by BERHANU, Aklile, KING, David S, MOSIER, Stacie, JORDAN, Robert, JONES, Kevin F, HRUBY, Dennis E, GROSENBACH, Douglas W

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Efficacy of ST-246 versus lethal poxvirus challenge in immunodeficient mice by Grosenbach, Douglas W, Berhanu, Aklile, King, David S, Mosier, Stacie, Jones, Kevin F, Jordan, Robert A, Bolken, Tove' C, Hruby, Dennis E

“…The threat of smallpox as a bioweapon and the emerging threat of human monkeypox, among other poxviral diseases, highlight the need for effective poxvirus…”
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The Vaccinia Virus F13L YPPL Motif Is Required for Efficient Release of Extracellular Enveloped Virus by HONEYCHURCH, Kady M, GUANG YANG, JORDAN, Robert, HRUBY, Dennis E

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