Search Results - "Dennis A. Hesselink"

Therapeutic Drug Monitoring of Tacrolimus-Personalized Therapy: Second Consensus Report by Brunet, Mercè, van Gelder, Teun, Åsberg, Anders, Haufroid, Vincent, Hesselink, Dennis A, Langman, Loralie, Lemaitre, Florian, Marquet, Pierre, Seger, Christoph, Shipkova, Maria, Vinks, Alexander, Wallemacq, Pierre, Wieland, Eberhard, Woillard, Jean Baptiste, Barten, Markus J, Budde, Klemens, Colom, Helena, Dieterlen, Maja-Theresa, Elens, Laure, Johnson-Davis, Kamisha L, Kunicki, Paweł K, MacPhee, Iain, Masuda, Satohiro, Mathew, Binu S, Millán, Olga, Mizuno, Tomoyuki, Moes, Dirk-Jan A R, Monchaud, Caroline, Noceti, Ofelia, Pawinski, Tomasz, Picard, Nicolas, van Schaik, Ron, Sommerer, Claudia, Vethe, Nils Tore, de Winter, Brenda, Christians, Uwe, Bergan, Stein

“…Ten years ago, a consensus report on the optimization of tacrolimus was published in this journal. In 2017, the Immunosuppressive Drugs Scientific Committee of…”
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The Role of Pharmacogenetics in the Disposition of and Response to Tacrolimus in Solid Organ Transplantation by Hesselink, Dennis A., Bouamar, Rachida, Elens, Laure, van Schaik, Ron H. N., van Gelder, Teun

“…The calcineurin inhibitor tacrolimus is the backbone of immunosuppressive drug therapy after solid organ transplantation. Tacrolimus is effective in preventing…”
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Personalized Therapy for Mycophenolate: Consensus Report by the International Association of Therapeutic Drug Monitoring and Clinical Toxicology by Bergan, Stein, Brunet, Mercè, Hesselink, Dennis A., Johnson-Davis, Kamisha L., Kunicki, Paweł K., Lemaitre, Florian, Marquet, Pierre, Molinaro, Mariadelfina, Noceti, Ofelia, Pattanaik, Smita, Pawinski, Tomasz, Seger, Christoph, Shipkova, Maria, Swen, Jesse J., van Gelder, Teun, Venkataramanan, Raman, Wieland, Eberhard, Woillard, Jean-Baptiste, Zwart, Tom C., Barten, Markus J., Budde, Klemens, Dieterlen, Maja-Theresa, Elens, Laure, Haufroid, Vincent, Masuda, Satohiro, Millan, Olga, Mizuno, Tomoyuki, Moes, Dirk J. A. R., Oellerich, Michael, Picard, Nicolas, Salzmann, Linda, Tönshoff, Burkhard, van Schaik, Ron H. N., Vethe, Nils Tore, Vinks, Alexander A., Wallemacq, Pierre, Åsberg, Anders, Langman, Loralie J.

“…When mycophenolic acid (MPA) was originally marketed for immunosuppressive therapy, fixed doses were recommended by the manufacturer. Awareness of the…”
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Direct detection of circulating donor-derived extracellular vesicles in kidney transplant recipients by Woud, Wouter W., Hesselink, Dennis A., Hoogduijn, Martin J., Baan, Carla C., Boer, Karin

“…Extracellular vesicles (EVs) are tissue-specific particles containing valuable diagnostic information. However, single EV analysis in blood is challenging due…”
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Preoperative right heart hemodynamics predict postoperative acute kidney injury after heart transplantation by Guven, Goksel, Brankovic, Milos, Constantinescu, Alina A., Brugts, Jasper J., Hesselink, Dennis A., Akin, Sakir, Struijs, Ard, Birim, Ozcan, Ince, Can, Manintveld, Olivier C., Caliskan, Kadir

“…Purpose Acute kidney injury ( AKI) frequently occurs after heart transplantation (HTx), but its relation to preoperative right heart hemodynamic (RHH)…”
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A New CYP3A53 and CYP3A422 Cluster Influencing Tacrolimus Target Concentrations: A Population Approach by Andreu, Franc, Colom, Helena, Elens, Laure, van Gelder, Teun, van Schaik, Ronald H. N., Hesselink, Dennis A., Bestard, Oriol, Torras, Joan, Cruzado, Josep M., Grinyó, Josep M., Lloberas, Nuria

“…Background Single nucleotide polymorphisms (SNPs) in the CYP3A5 and CYP3A4 genes have been reported to be an important cause of variability in the…”
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A New Functional CYP3A4 Intron 6 Polymorphism Significantly Affects Tacrolimus Pharmacokinetics in Kidney Transplant Recipients by ELENS, Laure, BOUAMAR, Rachida, HESSELINK, Dennis A, HAUFROID, Vincent, VAN DER HEIDEN, Ilse P, VAN GELDER, Teun, VAN SCHAIK, Ron H. N

“…Tacrolimus (Tac) is a potent immunosuppressant with considerable toxicity. Tac pharmacokinetics varies between individuals and thus complicates its use in…”
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The Effect of Tacrolimus and Mycophenolic Acid on CD14+ Monocyte Activation and Function by Kannegieter, Nynke M, Hesselink, Dennis A, Dieterich, Marjolein, Kraaijeveld, Rens, Rowshani, Ajda T, Leenen, Pieter J M, Baan, Carla C

“…Monocytes and macrophages play key roles in many disease states, including cellular and humoral rejection after solid organ transplantation (SOT). To suppress…”
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Iron deficiency after kidney transplantation by Vinke, Joanna Sophia J, Francke, Marith I, Eisenga, Michele F, Hesselink, Dennis A, de Borst, Martin H

“…Abstract Iron deficiency (ID) is highly prevalent in kidney transplant recipients (KTRs) and has been independently associated with an excess mortality risk in…”
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Pharmacogenetic Biomarkers Predictive of the Pharmacokinetics and Pharmacodynamics of Immunosuppressive Drugs by Picard, Nicolas, Bergan, Stein, Marquet, Pierre, van Gelder, Teun, Wallemacq, Pierre, Hesselink, Dennis A, Haufroid, Vincent

“…In association with therapeutic drug monitoring of immunosuppressive drugs, pharmacogenetics has rapidly emerged as an additional tool to refine dose selection…”
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Urinary Extracellular Vesicles Are a Novel Tool to Monitor Allograft Function in Kidney Transplantation: A Systematic Review by Wu, Liang, Boer, Karin, Woud, Wouter W, Udomkarnjananun, Suwasin, Hesselink, Dennis A, Baan, Carla C

“…Extracellular vesicles (EVs) are nanoparticles that transmit molecules from releasing cells to target cells. Recent studies link urinary EVs (uEV) to diverse…”
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Usage of Tacrolimus and Mycophenolic Acid During Conception, Pregnancy, and Lactation, and Its Implications for Therapeutic Drug Monitoring: A Systematic Critical Review by Le, Hoang Lan, Francke, Marith I., Andrews, Louise M., de Winter, Brenda C. M., van Gelder, Teun, Hesselink, Dennis A.

“…Conception, pregnancy, and lactation following solid organ transplantation require appropriate management. The most frequently used immunosuppressive drug…”
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Monitoring antihypertensive drug concentrations to determine nonadherence in hypertensive patients with or without a kidney transplant by Peeters, Laura E.J., Hesselink, Dennis A., Lafeber, Melvin, Severs, David, van den Hoogen, Martijn W.F., Sonneveld, Michelle A.H., Ramakers, Christian R.B., Bahmany, Soma, van Gelder, Teun, Koch, Birgit C.P., Versmissen, Jorie

“…Nonadherence to antihypertensive drugs (AHDs) is a major contributor to pseudo-resistant hypertension. The primary objective of this study was to determine the…”
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Therapeutic drug monitoring of immunosuppressive drugs in hepatology and gastroenterology by Udomkarnjananun, Suwasin, Francke, Marith I., De Winter, Brenda C.M., Mulder, Midas B., Baan, Carla C., Metselaar, Herold J., den Hoed, Caroline M., Hesselink, Dennis A.

“…Immunosuppressive drugs have been key to the success of liver transplantation and are essential components of the treatment of inflammatory bowel disease (IBD)…”
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Targeting the Monocyte-Macrophage Lineage in Solid Organ Transplantation by van den Bosch, Thierry P P, Kannegieter, Nynke M, Hesselink, Dennis A, Baan, Carla C, Rowshani, Ajda T

“…There is an unmet clinical need for immunotherapeutic strategies that specifically target the active immune cells participating in the process of rejection…”
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The combination of CYP3A422 and CYP3A53 single-nucleotide polymorphisms determines tacrolimus dose requirement after kidney transplantation by Lloberas, Nuria, Elens, Laure, Llaudó, Ines, Padullés, Ariadna, van Gelder, Teun, Hesselink, Dennis A, Colom, Helena, Andreu, Franc, Torras, Joan, Bestard, Oriol, Cruzado, Josep M, Gil-Vernet, Salvador, van Schaik, Ron, Grinyó, Josep M

“…INTRODUCTIONTacrolimus (Tac) has a narrow therapeutic window and shows large between-patient pharmacokinetic variability. As a result, over-immunosuppression…”
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Chlorthalidone Versus Amlodipine for Hypertension in Kidney Transplant Recipients Treated With Tacrolimus: A Randomized Crossover Trial by Moes, Arthur D., MD, Hesselink, Dennis A., MD, PhD, van den Meiracker, Anton H., MD, PhD, Zietse, Robert, MD, PhD, Hoorn, Ewout J., MD, PhD

“…Background Chlorthalidone is a very effective antihypertensive drug, but it has not been studied prospectively in kidney transplant recipients with…”
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Tacrolimus intra-patient variability is not associated with chronic active antibody mediated rejection by Sablik, Kasia A, Clahsen-van Groningen, Marian C, Hesselink, Dennis A, van Gelder, Teun, Betjes, Michiel G H

“…Chronic active antibody mediated rejection (c-aABMR) is a major cause of long-term kidney allograft loss. It is hypothesized that frequent sub-therapeutic…”
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A Population Pharmacokinetic Model to Predict the Individual Starting Dose of Tacrolimus Following Pediatric Renal Transplantation by Andrews, Louise M., Hesselink, Dennis A., van Gelder, Teun, Koch, Birgit C. P., Cornelissen, Elisabeth A. M., Brüggemann, Roger J. M., van Schaik, Ron H. N., de Wildt, Saskia N., Cransberg, Karlien, de Winter, Brenda C. M.

“…Background Multiple clinical, demographic, and genetic factors affect the pharmacokinetics of tacrolimus in children, yet in daily practice, a uniform…”
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A systematic review and meta-analysis of enzyme-linked immunosorbent spot (ELISPOT) assay for BK polyomavirus immune response monitoring after kidney transplantation by Udomkarnjananun, Suwasin, Kerr, Stephen J., Francke, Marith I., Avihingsanon, Yingyos, van Besouw, Nicole M., Baan, Carla C., Hesselink, Dennis A.

“…•Immune-monitoring for BKV infection in kidney transplant recipient is needed.•This meta-analysis showed that IFN-γ ELISPOT is a potential tool to monitor the…”
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