Synthesis, cytotoxicity, DNA interaction and cell cycle studies of trans-diiodophosphine Pt(II) complexes

Platinum complexes, bearing aliphatic amines and phosphine ligands in trans configuration with iodide as leaving groups, are synthesized and characterized. The crystal structure of trans-PtI2(isopropylamine)(PPh3) is reported. The complex bearing isopropylamine is demonstrated to be the best candida...

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Bibliographic Details
Published in:	Dalton transactions : an international journal of inorganic chemistry Vol. 44; no. 8; p. 3557
Main Authors:	Medrano, Angeles, Dennis, Stephen M, Alvarez-Valdés, Amparo, Perles, Josefina, McGregor Mason, Tracey, Quiroga, Adoracion G
Format:	Journal Article
Language:	English
Published:	England 28-02-2015
Subjects:	Apoptosis - drug effects Cell Line, Tumor Coordination Complexes - chemical synthesis Coordination Complexes - chemistry Coordination Complexes - toxicity Crystallography, X-Ray DNA - chemistry G2 Phase Cell Cycle Checkpoints - drug effects HCT116 Cells Humans M Phase Cell Cycle Checkpoints - drug effects Molecular Conformation Phosphines - chemistry Plasmids - chemistry Platinum - chemistry
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Summary:	Platinum complexes, bearing aliphatic amines and phosphine ligands in trans configuration with iodide as leaving groups, are synthesized and characterized. The crystal structure of trans-PtI2(isopropylamine)(PPh3) is reported. The complex bearing isopropylamine is demonstrated to be the best candidate as its cytotoxic activity is comparable to or better than cisplatin. A remarkably higher interaction of the complexes with DNA is reported as compared to the parent chlorido series. Cell cycle studies of the complexes in six human cell lines are performed and also compared with the previous series.
ISSN:	1477-9234
DOI:	10.1039/c4dt02392g