Search Results - "Dennis, R"

Advancing an HIV vaccine; advancing vaccinology by Burton, Dennis R.

“…Of any pathogen, HIV provides perhaps the greatest challenge to successful vaccine development. Nevertheless, progress continued to be made in 2018; new…”
Get full text

Recent progress in broadly neutralizing antibodies to HIV by Sok, Devin, Burton, Dennis R.

“…In this Review, we highlight some recent developments in the discovery and application of broadly neutralizing antibodies (bnAbs) to human immunodeficiency…”
Get full text

Broadly Neutralizing Antibodies to HIV and Their Role in Vaccine Design by Burton, Dennis R, Hangartner, Lars

“…HIV employs multiple means to evade the humoral immune response, particularly the elicitation of and recognition by broadly neutralizing antibodies (bnAbs)…”
Get full text

Antiviral neutralizing antibodies: from in vitro to in vivo activity by Burton, Dennis R.

“…Neutralizing antibodies (nAbs) are being increasingly used as passive antiviral reagents in prophylactic and therapeutic modalities and to guide viral vaccine…”
Get full text

What Are the Most Powerful Immunogen Design Vaccine Strategies? Reverse Vaccinology 2.0 Shows Great Promise by Burton, Dennis R

“…Functional antibodies, i.e., those with antipathogen activity in in vitro assays, are generally the best correlate of vaccine protection. Mimics of natural…”
Get full text

Considerations for the Design of Antibody-Based Therapeutics by Goulet, Dennis R, Atkins, William M

“…Antibody-based proteins have become an important class of biologic therapeutics, due in large part to the stability, specificity, and adaptability of the…”
Get more information

Passive immunotherapy of viral infections: 'super-antibodies' enter the fray by Walker, Laura M., Burton, Dennis R.

“…Key Points Antibodies have been used for over a century prophylactically and, less often, therapeutically against viruses. 'Super-antibodies' — a new…”
Get full text

Commonality despite exceptional diversity in the baseline human antibody repertoire by Briney, Bryan, Inderbitzin, Anne, Joyce, Collin, Burton, Dennis R.

“…In principle, humans can produce an antibody response to any non-self-antigen molecule in the appropriate context. This flexibility is achieved by the presence…”
Get full text

Multiscale molecular modelling: from electronic structure to dynamics of nanosystems and beyond by Salahub, Dennis R

“…Important contemporary biological and materials problems often depend on interactions that span orders of magnitude differences in spatial and temporal…”
Get more information

Rational Vaccine Design in the Time of COVID-19 by Burton, Dennis R, Walker, Laura M

“…As scientists consider SARS-CoV-2 vaccine design, we discuss problems that may be encountered and how to tackle them by what we term "rational vaccine design."…”
Get full text

The dynamics of DNA methylation in schizophrenia and related psychiatric disorders by Grayson, Dennis R, Guidotti, Alessandro

“…Major psychiatric disorders such as schizophrenia (SZ) and bipolar disorder (BP) with psychosis (BP+) express a complex symptomatology characterized by…”
Get full text

On the path to [Fe-S] protein maturation: A personal perspective by Dean, Dennis R.

“…Azotobacter vinelandii is a genetically tractable Gram-negative proteobacterium able to fix nitrogen (N2) under aerobic growth conditions. This narrative…”
Get full text

Phospholipid regulation of innate immunity and respiratory viral infection by Voelker, Dennis R., Numata, Mari

“…Toll-like receptors (TLRs) coupled to intracellular signaling cascades function as central elements of innate immunity that control transcription of numerous…”
Get full text

An overview of the chemistry and biology of reactive aldehydes by Fritz, Kristofer S., Petersen, Dennis R.

“…The nonenzymatic free radical generation of reactive aldehydes is known to contribute to diseases of sustained oxidative stress including rheumatoid arthritis,…”
Get full text

A review of building information modeling (BIM) and the internet of things (IoT) devices integration: Present status and future trends by Tang, Shu, Shelden, Dennis R., Eastman, Charles M., Pishdad-Bozorgi, Pardis, Gao, Xinghua

“…The integration of Building Information Modeling (BIM) with real-time data from the Internet of Things (IoT) devices presents a powerful paradigm for…”
Get full text

Powered robotic exoskeletons in post-stroke rehabilitation of gait: a scoping review by Louie, Dennis R, Eng, Janice J

“…Powered robotic exoskeletons are a potential intervention for gait rehabilitation in stroke to enable repetitive walking practice to maximize neural recovery…”
Get full text

Antibody responses to envelope glycoproteins in HIV-1 infection by Burton, Dennis R, Mascola, John R

“…Antibody responses to the HIV-1 envelope glycoproteins can be classified into three groups. Burton and Mascola discuss how recent insight into the structure…”
Get full text

Making heads or tails of phospholipids in mitochondria by Osman, Christof, Voelker, Dennis R, Langer, Thomas

“…Mitochondria are dynamic organelles whose functional integrity requires a coordinated supply of proteins and phospholipids. Defined functions of specific…”
Get full text

The cryo-EM structure of intraflagellar transport trains reveals how dynein is inactivated to ensure unidirectional anterograde movement in cilia by Jordan, Mareike A., Diener, Dennis R., Stepanek, Ludek, Pigino, Gaia

“…Movement of cargos along microtubules plays key roles in diverse cellular processes, from signalling to mitosis. In cilia, rapid movement of ciliary components…”
Get full text

Copper metallochaperones by Robinson, Nigel J, Winge, Dennis R

“…The current state of knowledge on how copper metallochaperones support the maturation of cuproproteins is reviewed. Copper is needed within mitochondria to…”
Get full text