Search Results - "Denning, Warren L"

Metastasis suppressors in breast cancers: mechanistic insights and clinical potential by Bohl, Christopher R., Harihar, Sitaram, Denning, Warren L., Sharma, Rahul, Welch, Danny R.

“…For the most part, normal epithelial cells do not disseminate to other parts of the body and proliferate, as do metastatic cells. Presumably, a class of…”
Get full text

Dysregulation of Systemic and Mucosal Humoral Responses to Microbial and Food Antigens as a Factor Contributing to Microbial Translocation and Chronic Inflammation in HIV-1 Infection by Hel, Zdenek, Xu, Jun, Denning, Warren L, Helton, E Scott, Huijbregts, Richard P H, Heath, Sonya L, Overton, E Turner, Christmann, Benjamin S, Elson, Charles O, Goepfert, Paul A, Mestecky, Jiri

“…HIV-1 infection is associated with an early and profound depletion of mucosal memory CD4+ T cells, a population that plays an indispensable role in the…”
Get full text

Epithelial-Mesenchymal Transition Is Associated with a Distinct Tumor Microenvironment Including Elevation of Inflammatory Signals and Multiple Immune Checkpoints in Lung Adenocarcinoma by Lou, Yanyan, Diao, Lixia, Cuentas, Edwin Roger Parra, Denning, Warren L, Chen, Limo, Fan, You Hong, Byers, Lauren A, Wang, Jing, Papadimitrakopoulou, Vassiliki A, Behrens, Carmen, Rodriguez, Jaime Canales, Hwu, Patrick, Wistuba, Ignacio I, Heymach, John V, Gibbons, Don L

“…Promising results in the treatment of non-small cell lung cancer (NSCLC) have been seen with agents targeting immune checkpoints, such as programmed cell death…”
Get full text

STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment by Koyama, Shohei, Akbay, Esra A, Li, Yvonne Y, Aref, Amir R, Skoulidis, Ferdinandos, Herter-Sprie, Grit S, Buczkowski, Kevin A, Liu, Yan, Awad, Mark M, Denning, Warren L, Diao, Lixia, Wang, Jing, Parra-Cuentas, Edwin R, Wistuba, Ignacio I, Soucheray, Margaret, Thai, Tran, Asahina, Hajime, Kitajima, Shunsuke, Altabef, Abigail, Cavanaugh, Jillian D, Rhee, Kevin, Gao, Peng, Zhang, Haikuo, Fecci, Peter E, Shimamura, Takeshi, Hellmann, Matthew D, Heymach, John V, Hodi, F Stephen, Freeman, Gordon J, Barbie, David A, Dranoff, Glenn, Hammerman, Peter S, Wong, Kwok-Kin

“…STK11/LKB1 is among the most commonly inactivated tumor suppressors in non-small cell lung cancer (NSCLC), especially in tumors harboring KRAS mutations. Many…”
Get full text

Limited transplantation of antigen-expressing hematopoietic stem cells induces long-lasting cytotoxic T cell responses by Denning, Warren L, Xu, Jun, Guo, Siqi, Klug, Christopher A, Hel, Zdenek

“…Harnessing the ability of cytotoxic T lymphocytes (CTLs) to recognize and eradicate tumor or pathogen-infected cells is a critical goal of modern immune-based…”
Get full text

Antitumor activity of CD56-chimeric antigen receptor T cells in neuroblastoma and SCLC models by Crossland, Denise L., Denning, Warren L., Ang, Sonny, Olivares, Simon, Mi, Tiejuan, Switzer, Kirsten, Singh, Harjeet, Huls, Helen, Gold, Kate S., Glisson, Bonnie S., Cooper, Laurence J., Heymach, John V.

“…The CD56 antigen (NCAM-1) is highly expressed on several malignancies with neuronal or neuroendocrine differentiation, including small-cell lung cancer and…”
Get full text

Metastasis Suppressor KISS1 Seems to Reverse the Warburg Effect by Enhancing Mitochondrial Biogenesis by WEN LIU, BECK, Benjamin H, DHAR, Animesh, IWAKUMA, Tomoo, WELCH, Danny R, VAIDYA, Kedar S, NASH, Kevin T, FEELEY, Kyle P, BALLINGER, Scott W, POUNDS, Keke M, DENNING, Warren L, DIERS, Anne R, LANDAR, Aimee

“…Cancer cells tend to utilize aerobic glycolysis even under normoxic conditions, commonly called the "Warburg effect." Aerobic glycolysis often directly…”
Get full text

Abstract 4137: Loss of LKB1 mediates an immune inert phenotype in human lung adenocarcinoma by Denning, Warren L., Skoulidis, Ferdinandos, Shen, Li, Papadimitrakopoulou, Vassiliki, Diao, Lixia, Lou, Yanyan, Byers, Lauren A., Wang, Jing, Canales, Jaime R., Wistuba, Ignacio I., Weinstein, John, Gibbons, Don L., Heymach, John V.

“…Abstract Background: We recently have reported that co-mutations within KRAS-mutated lung adenocarcinoma (LUAD) define a distinct biological phenotype and may…”
Get full text

CD4 T Cell-Induced, Bid-Dependent Apoptosis of Cutaneous Dendritic Cells Regulates T Cell Expansion and Immune Responses by Pradhan, Sanjay, Genebriera, Joseph, Denning, Warren L, Felix, Kumar, Elmets, Craig A, Timares, Laura

“…The fate of dendritic cells (DCs) after Ag presentation may be DC subset-specific and controlled by many factors. The role of activation-induced apoptosis in…”
Get full text

STK11/LKB1 Mutations and PD-1 Inhibitor Resistance in KRAS -Mutant Lung Adenocarcinoma by Skoulidis, Ferdinandos, Goldberg, Michael E, Greenawalt, Danielle M, Hellmann, Matthew D, Awad, Mark M, Gainor, Justin F, Schrock, Alexa B, Hartmaier, Ryan J, Trabucco, Sally E, Gay, Laurie, Ali, Siraj M, Elvin, Julia A, Singal, Gaurav, Ross, Jeffrey S, Fabrizio, David, Szabo, Peter M, Chang, Han, Sasson, Ariella, Srinivasan, Sujaya, Kirov, Stefan, Szustakowski, Joseph, Vitazka, Patrik, Edwards, Robin, Bufill, Jose A, Sharma, Neelesh, Ou, Sai-Hong I, Peled, Nir, Spigel, David R, Rizvi, Hira, Aguilar, Elizabeth Jimenez, Carter, Brett W, Erasmus, Jeremy, Halpenny, Darragh F, Plodkowski, Andrew J, Long, Niamh M, Nishino, Mizuki, Denning, Warren L, Galan-Cobo, Ana, Hamdi, Haifa, Hirz, Taghreed, Tong, Pan, Wang, Jing, Rodriguez-Canales, Jaime, Villalobos, Pamela A, Parra, Edwin R, Kalhor, Neda, Sholl, Lynette M, Sauter, Jennifer L, Jungbluth, Achim A, Mino-Kenudson, Mari, Azimi, Roxana, Elamin, Yasir Y, Zhang, Jianjun, Leonardi, Giulia C, Jiang, Fei, Wong, Kwok-Kin, Lee, J Jack, Papadimitrakopoulou, Vassiliki A, Wistuba, Ignacio I, Miller, Vincent A, Frampton, Garrett M, Wolchok, Jedd D, Shaw, Alice T, Jänne, Pasi A, Stephens, Philip J, Rudin, Charles M, Geese, William J, Albacker, Lee A, Heymach, John V

“…is the most common oncogenic driver in lung adenocarcinoma (LUAC). We previously reported that (KL) or (KP) comutations define distinct subgroups of -mutant…”
Get more information

Abstract 456: Defined co-mutation subgroups of KRAS-mutated NSCLC display distinct immune profiles by Denning, Warren L., Diao, Lixia, Skoulidis, Ferdinandos, Lou, Yanyan, Byers, Lauren, Wang, Jing, Weinstein, John, Gibbons, Don, Heymach, John

“…Abstract Traditional pathological divisions of lung cancer are giving rise to molecular classifications that identify unique drivers of tumor malignancy. Of…”
Get full text

Abstract 3364: Epithelial-mesenchymal transition is associated with a profound inflammatory tumor microenvironment in lung adenocarcinoma by Lou, Yanyan, Diao, Lixia, Roger, Parra Cuentas Edwin, Denning, Warren L., Chen, Limo, Fan, Youhong, Rodriguez, Jaime, Byers, Lauren, Wang, Jing, Papadimitrakopoulou, Vassiliki, Carmen, Behrens, Wistuba, Ignacio I., Hwu, Patrick, Heymach, John V., Gibbons, Don L.

“…Abstract Promising results in the treatment of non-small cell lung cancer (NSCLC) have been seen with immunomodulatory agents targeting immune checkpoints,…”
Get full text

Metastasis suppressor KISS1 appears to reverse the Warburg effect by enhancing mitochondrial biogenesis by Liu, Wen, Beck, Benjamin H., Vaidya, Kedar S., Nash, Kevin T., Feeley, Kyle P., Ballinger, Scott W., Pounds, Keke M., Denning, Warren L., Diers, Anne R., Landar, Aimee, Dhar, Animesh, Iwakuma, Tomoo, Welch, Danny R.

“…Cancer cells tend to utilize aerobic glycolysis even under normoxic conditions, commonly called the “Warburg Effect.” Aerobic glycolysis often directly…”
Get full text

Limited transplantation of antigen-expressing hematopoietic stem cells induces long-lasting cytotoxic T cell responses and effect of altered suppressive myeloid population on HIV-disease progression by Denning, Warren L

“…While each type of cancer and chronic viral infection has its own specific pathology, they share two common mechanisms of immune evasion. The first mechanism…”
Get full text