Search Results - "Denning, Krista L."

High BMI Is Associated with Changes in Peritumor Breast Adipose Tissue That Increase the Invasive Activity of Triple-Negative Breast Cancer Cells by Miracle, Cora E, McCallister, Chelsea L, Denning, Krista L, Russell, Rebecca, Allen, Jennifer, Lawrence, Logan, Legenza, Mary, Krutzler-Berry, Diane, Salisbury, Travis B

“…Breast cancer is the most common cancer in women with multiple risk factors including smoking, genetics, environmental factors, and obesity. Smoking and…”
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Osteoregenerative Potential of 3D-Printed Poly ε -Caprolactone Tissue Scaffolds In Vitro Using Minimally Manipulative Expansion of Primary Human Bone Marrow Stem Cells by Lawrence, Logan M, Salary, Roozbeh Ross, Miller, Virginia, Valluri, Anisha, Denning, Krista L, Case-Perry, Shannon, Abdelgaber, Karim, Smith, Shannon, Claudio, Pier Paolo, Day, James B

“…The repair of orthopedic and maxillofacial defects in modern medicine currently relies heavily on the use of autograft, allograft, void fillers, or other…”
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Capsaicinoids: Multiple effects on angiogenesis, invasion and metastasis in human cancers by Friedman, Jamie R., Richbart, Stephen D., Merritt, Justin C., Brown, Kathleen C., Denning, Krista L., Tirona, Maria T., Valentovic, Monica A., Miles, Sarah L., Dasgupta, Piyali

“…Cancer progression is a complex multistep process comprising of angiogenesis of the primary tumor, its invasion into the surrounding stroma and its migration…”
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Anticancer Activity of Region B Capsaicin Analogs by Brown, Kathleen C., Modi, Kushal J., Light, Reagan S., Cox, Ashley J., Long, Timothy E., Gadepalli, Rama S., Rimoldi, John M., Miles, Sarah L., Rankin, Gary, Valentovic, Monica, Denning, Krista L., Tirona, Maria T., Finch, Paul T., Hess, Joshua A., Dasgupta, Piyali

“…The heterocyclic vanilloid compound capsaicin is responsible for the spicy and pungent flavor of chili peppers. Several convergent studies have shown that…”
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mTOR Regulation of N-Myc Downstream Regulated 1 (NDRG1) Phosphorylation in Clear Cell Renal Cell Carcinoma by Valluri, Anisha, Wellman, Jessica, McCallister, Chelsea L, Brown, Kathleen C, Lawrence, Logan, Russell, Rebecca, Jensen, James, Denvir, James, Valentovic, Monica A, Denning, Krista L, Salisbury, Travis B

“…The mechanistic target of rapamycin (mTOR) kinase is a component of two signaling complexes that are known as mTOR complex 1 (mTORC1) and mTORC2. We sought to…”
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Minimally Manipulative Method for the Expansion of Human Bone Marrow Mesenchymal Stem Cells to Treat Osseous Defects by Lawrence, Logan M, Cottrill, Andrew, Valluri, Amrita, Marenzi, Gaetano, Denning, Krista L, Valluri, Jagan, Claudio, Pier Paolo, Day, James B

“…Lack of standardization of clinically compliant culture protocols of mesenchymal stem cells for re-implantation in humans have hindered clinical progress in…”
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Hepatocyte-Specific PEX16 Abrogation in Mice Leads to Hepatocyte Proliferation, Alteration of Hepatic Lipid Metabolism, and Resistance to High-Fat Diet (HFD)-Induced Hepatic Steatosis and Obesity by Chen, Xue, Wang, Long, Denning, Krista L, Mazur, Anna, Xu, Yujuan, Wang, Kesheng, Lawrence, Logan M, Wang, Xiaodong, Lu, Yongke

“…Obesity results in hepatic fat accumulation, i.e., steatosis. In addition to fat overload, impaired fatty acid β-oxidation also promotes steatosis. Fatty acid…”
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Cancer Stem Cell Chemotherapeutics Assay for Prospective Treatment of Recurrent Glioblastoma and Progressive Anaplastic Glioma: A Single-Institution Case Series by Ranjan, Tulika, Howard, Candace M., Yu, Alexander, Xu, Linda, Aziz, Khaled, Jho, David, Leonardo, Jodi, Hameed, Muhammad A., Karlovits, Stephen M., Wegner, Rodney E., Fuhrer, Russell, Lirette, Seth T., Denning, Krista L., Valluri, Jagan, Claudio, Pier Paolo

“…BACKGROUND: Chemotherapy-resistant cancer stem cells (CSC) may lead to tumor recurrence in glioblastoma (GBM). The poor prognosis of this disease emphasizes…”
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PPARα agonist WY-14,643 induces the PLA2/COX-2/ACOX1 pathway to enhance peroxisomal lipid metabolism and ameliorate alcoholic fatty liver in mice by Xu, Yunhui, Denning, Krista L., Lu, Yongke

“…Peroxisome proliferator-activated receptor α (PPARα) regulates fatty acid oxidation (FAO). Usually, very-long chain fatty acids are first activated by acyl-CoA…”
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Cardiac Glycosides Increase Temozolomide Anticancer Activity in Therapy Resistant Glioblastoma Cells by Valluri, Anisha, Lawrence, Logan, Denning, Krista L., Cuda, Jonathan, Zhu, Guo-Zhang

“…Glioblastomas (GBMs) are a form of malignant gliomas characterized by a dismal prognosis. Standard treatment for glioblastoma patients is combined maximal…”
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Lymphatic microvessel density as prognostic marker in colorectal cancer by Saad, Reda S, Kordunsky, Lana, Liu, Yulin L, Denning, Krista L, Kandil, Hosam A, Silverman, Jan F

“…Lymph node metastases is an important prognostic indicator for disease progression and crucial for therapeutic strategies in the work-up of colorectal…”
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PPARα agonist WY-14,643 induces adipose atrophy and fails to blunt chronic ethanol-induced hepatic fat accumulation in mice lacking adipose FGFR1 by Xu, Yunhui, Denning, Krista L., Lu, Yongke

“…[Display omitted] Fibroblast growth factor 21 (FGF21) is mainly regulated by peroxisome proliferator-activated receptor α (PPARα) in liver. The PPARα-FGF21…”
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Chemo-predictive assay for targeting cancer stem-like cells in patients affected by brain tumors by Mathis, Sarah E, Alberico, Anthony, Nande, Rounak, Neto, Walter, Lawrence, Logan, McCallister, Danielle R, Denvir, James, Kimmey, Gerrit A, Mogul, Mark, Oakley, 3rd, Gerard, Denning, Krista L, Dougherty, Thomas, Valluri, Jagan V, Claudio, Pier Paolo

“…Administration of ineffective anticancer therapy is associated with unnecessary toxicity and development of resistant clones. Cancer stem-like cells (CSLCs)…”
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PPARα agonist WY-14,643 enhances ethanol metabolism in mice: Role of catalase by Chen, Xue, Xu, Yunhui, Denning, Krista L., Grigore, Audrey, Lu, Yongke

“…Peroxisome proliferator-activated receptor α (PPARα), a fatty acid oxidation regulator, inhibits alcohol-induced fatty liver (AFL). PPARα agonist WY-14,643…”
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Under peroxisome proliferation acyl-CoA oxidase coordinates with catalase to enhance ethanol metabolism by Chen, Xue, Denning, Krista L., Mazur, Anna, Lawrence, Logan M., Wang, Xiaodong, Lu, Yongke

“…In peroxisomes, acyl-CoA oxidase (ACOX) oxidizes fatty acids and produces H2O2, and the latter is decomposed by catalase. If ethanol is present, ethanol will…”
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S4446 Patients Don’t Read Medical Textbooks: A Case Study Showing an Atypical Presentation of Liver Pathology by Torres, Adolfo A., Cessna, Lily, Dhulashia, Para, Garala, Isha, Turki, M'hamed, Lawrence, Logan, Denning, Krista L., Joshi, Tejas

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Primary pulmonary follicular dendritic cell neoplasm: a case report and review of the literature by Denning, Krista L, Olson, Peter R, Maley, Jr, Richard H, Flati, Veronica R, Myers, Jeffrey L, Silverman, Jan F

“…Follicular dendritic cell tumor (FDCT) is an uncommon neoplasm that typically presents as a slow-growing, painless mass without systemic symptoms…”
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Anti‐invasive and anti‐metastatic activity of capsaicin and natural capsaicin‐like compounds in lung adenocarcinoma by Richbart, Stephen D., Nolan, Nicholas A., Akers, Austin T., Brown, Kathleen C., Denning, Krista L., Egleton, Richard D., Dasgupta, Piyali

“…Lung adenocarcinoma (LAC) accounts for about 65% of all non‐small cell lung cancer (NSCLC) cases. A considerable proportion of LAC patients present (in the…”
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High-fat diet induces fibrosis in mice lacking CYP2A5 and PPARα: a new model for steatohepatitis-associated fibrosis by Chen, Xue, Acquaah-Mensah, George K, Denning, Krista L, Peterson, Jonathan M, Wang, Kesheng, Denvir, James, Hong, Feng, Cederbaum, Arthur I, Lu, Yongke

“…Obesity is linked to nonalcoholic steatohepatitis. Peroxisome proliferator-activated receptor-α (PPARα) regulates lipid metabolism. Cytochrome -450 2A5…”
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Capsaicin synergizes with camptothecin to induce increased apoptosis in human small cell lung cancers via the calpain pathway by Friedman, Jamie R., Perry, Haley E., Brown, Kathleen C., Gao, Ying, Lin, Ju, Stevenson, Cathyrn D., Hurley, John D., Nolan, Nicholas A., Akers, Austin T., Chen, Yi Charlie, Denning, Krista L., Brown, Linda G., Dasgupta, Piyali

“…[Display omitted] Small cell lung cancer (SCLC) is characterized by excellent initial response to chemotherapy and radiation therapy with a majority of the…”
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