Search Results - "Denning, Chris"

Complex Relationship Between Cardiac Fibroblasts and Cardiomyocytes in Health and Disease by Hall, Caitlin, Gehmlich, Katja, Denning, Chris, Pavlovic, Davor

“…Cardiac fibroblasts are the primary cell type responsible for deposition of extracellular matrix in the heart, providing support to the contracting myocardium…”
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Drug evaluation in cardiomyocytes derived from human induced pluripotent stem cells carrying a long QT syndrome type 2 mutation by MATSA, Elena, RAJAMOHAN, Divya, DICK, Emily, YOUNG, Lorraine, MELLOR, Ian, STANIFORTH, Andrew, DENNING, Chris

“…Congenital long QT syndromes (LQTSs) are associated with prolonged ventricular repolarization and sudden cardiac death. Limitations to existing clinical…”
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Simultaneous measurement of excitation-contraction coupling parameters identifies mechanisms underlying contractile responses of hiPSC-derived cardiomyocytes by van Meer, Berend J., Krotenberg, Ana, Sala, Luca, Davis, Richard P., Eschenhagen, Thomas, Denning, Chris, Tertoolen, Leon G. J., Mummery, Christine L.

“…Cardiomyocytes from human induced pluripotent stem cells (hiPSC-CMs) are increasingly recognized as valuable for determining the effects of drugs on ion…”
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Highly efficient delivery of functional cargoes by the synergistic effect of GAG binding motifs and cell-penetrating peptides by Dixon, James E., Osman, Gizem, Morris, Gavin E., Markides, Hareklea, Rotherham, Michael, Bayoussef, Zahia, Haj, Alicia J. El, Denning, Chris, Shakesheff, Kevin M.

“…Protein transduction domains (PTDs) are powerful nongenetic tools that allow intracellular delivery of conjugated cargoes to modify cell behavior. Their use in…”
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Isogenic models of hypertrophic cardiomyopathy unveil differential phenotypes and mechanism-driven therapeutics by Bhagwan, Jamie R., Mosqueira, Diogo, Chairez-Cantu, Karolina, Mannhardt, Ingra, Bodbin, Sara E., Bakar, Mine, Smith, James G.W., Denning, Chris

“…Hypertrophic cardiomyopathy (HCM) is a prevalent and complex cardiovascular condition. Despite being strongly associated with genetic alterations, wide…”
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Force and Calcium Transients Analysis in Human Engineered Heart Tissues Reveals Positive Force-Frequency Relation at Physiological Frequency by Saleem, Umber, Mannhardt, Ingra, Braren, Ingke, Denning, Chris, Eschenhagen, Thomas, Hansen, Arne

“…Force measurements in ex vivo and engineered heart tissues are well established. Analysis of calcium transients (CaT) is complementary to force, and the…”
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Evaluating the utility of cardiomyocytes from human pluripotent stem cells for drug screening by Dick, Emily, Rajamohan, Divya, Ronksley, Jonathon, Denning, Chris

“…Functional cardiomyocytes can now be derived routinely from hPSCs (human pluripotent stem cells), which collectively include embryonic and induced pluripotent…”
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Students' Views towards Sars-Cov-2 Mass Asymptomatic Testing, Social Distancing and Self-Isolation in a University Setting during the COVID-19 Pandemic: A Qualitative Study by Blake, Holly, Knight, Holly, Jia, Ru, Corner, Jessica, Morling, Joanne R, Denning, Chris, Ball, Jonathan K, Bolton, Kirsty, Figueredo, Grazziela, Morris, David E, Tighe, Patrick, Villalon, Armando Mendez, Ayling, Kieran, Vedhara, Kavita

“…We aimed to explore university students' perceptions and experiences of SARS-CoV-2 mass asymptomatic testing, social distancing and self-isolation, during the…”
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Blinded, Multicenter Evaluation of Drug-induced Changes in Contractility Using Human-induced Pluripotent Stem Cell-derived Cardiomyocytes by Saleem, Umber, van Meer, Berend J, Katili, Puspita A, Mohd Yusof, Nurul A N, Mannhardt, Ingra, Garcia, Ana Krotenberg, Tertoolen, Leon, de Korte, Tessa, Vlaming, Maria L H, McGlynn, Karen, Nebel, Jessica, Bahinski, Anthony, Harris, Kate, Rossman, Eric, Xu, Xiaoping, Burton, Francis L, Smith, Godfrey L, Clements, Peter, Mummery, Christine L, Eschenhagen, Thomas, Hansen, Arne, Denning, Chris

“…Abstract Animal models are 78% accurate in determining whether drugs will alter contractility of the human heart. To evaluate the suitability of human-induced…”
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A secreted proteomic footprint for stem cell pluripotency by Lewis, Philip A, Silajdžić, Edina, Smith, Helen, Bates, Nicola, Smith, Christopher A, Mancini, Fabrizio E, Knight, David, Denning, Chris, Brison, Daniel R, Kimber, Susan J

“…With a view to developing a much-needed non-invasive method for monitoring the healthy pluripotent state of human stem cells in culture, we undertook proteomic…”
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Combined hydrogels that switch human pluripotent stem cells from self-renewal to differentiation by Dixon, James E., Shah, Disheet A., Rogers, Catherine, Hall, Stephen, Weston, Nicola, Parmenter, Christopher D. J., McNally, Donal, Denning, Chris, Shakesheff, Kevin M.

“…The ability of materials to define the architecture and microenvironment experienced by cells provides new opportunities to direct the fate of human…”
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Modeling and study of the mechanism of dilated cardiomyopathy using induced pluripotent stem cells derived from individuals with Duchenne muscular dystrophy by Lin, Bo, Li, Yang, Han, Lu, Kaplan, Aaron D, Ao, Ying, Kalra, Spandan, Bett, Glenna C L, Rasmusson, Randall L, Denning, Chris, Yang, Lei

“…Duchenne muscular dystrophy (DMD) is caused by mutations in the dystrophin gene (DMD), and is characterized by progressive weakness in skeletal and cardiac…”
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Automated Electrophysiological and Pharmacological Evaluation of Human Pluripotent Stem Cell-Derived Cardiomyocytes by Rajamohan, Divya, Kalra, Spandan, Duc Hoang, Minh, George, Vinoj, Staniforth, Andrew, Russell, Hugh, Yang, Xuebin, Denning, Chris

“…Automated planar patch clamp systems are widely used in drug evaluation studies because of their ability to provide accurate, reliable, and reproducible data…”
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Transgenic Enrichment of Cardiomyocytes From Human Embryonic Stem Cells by Anderson, David, Self, Tim, Mellor, Ian R, Goh, Gareth, Hill, Stephen J, Denning, Chris

“…To realize the full scientific and clinical potential of human embryonic stem cell (hESC)-cardiomyocytes, strategies to overcome the high degree of…”
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Chronic activation of human cardiac fibroblasts in vitro attenuates the reversibility of the myofibroblast phenotype by Hall, Caitlin, Law, Jonathan P., Reyat, Jasmeet S., Cumberland, Max J., Hang, Shaun, Vo, Nguyen T. N., Raniga, Kavita, Weston, Chris J., O’Shea, Christopher, Townend, Jonathan N., Gehmlich, Katja, Ferro, Charles J., Denning, Chris, Pavlovic, Davor

“…Activation of cardiac fibroblasts and differentiation to myofibroblasts underlies development of pathological cardiac fibrosis, leading to arrhythmias and…”
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Non-invasive label-free monitoring the cardiac differentiation of human embryonic stem cells in-vitro by Raman spectroscopy by Pascut, Flavius C., Kalra, Spandan, George, Vinoj, Welch, Nathan, Denning, Chris, Notingher, Ioan

“…Online label-free monitoring of in-vitro differentiation of stem cells remains a major challenge in stem cell research. In this paper we report the use of…”
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Impairment of the ER/mitochondria compartment in human cardiomyocytes with PLN p.Arg14del mutation by Cuello, Friederike, Knaust, Anika E, Saleem, Umber, Loos, Malte, Raabe, Janice, Mosqueira, Diogo, Laufer, Sandra, Schweizer, Michaela, van der Kraak, Petra, Flenner, Frederik, Ulmer, Bärbel M, Braren, Ingke, Yin, Xiaoke, Theofilatos, Konstantinos, Ruiz‐Orera, Jorge, Patone, Giannino, Klampe, Birgit, Schulze, Thomas, Piasecki, Angelika, Pinto, Yigal, Vink, Aryan, Hübner, Norbert, Harding, Sian, Mayr, Manuel, Denning, Chris, Eschenhagen, Thomas, Hansen, Arne

“…The phospholamban (PLN) p.Arg14del mutation causes dilated cardiomyopathy, with the molecular disease mechanisms incompletely understood. Patient dermal…”
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Comparison of 10 Control hPSC Lines for Drug Screening in an Engineered Heart Tissue Format by Mannhardt, Ingra, Saleem, Umber, Mosqueira, Diogo, Loos, Malte F., Ulmer, Bärbel M., Lemoine, Marc D., Larsson, Camilla, Améen, Caroline, de Korte, Tessa, Vlaming, Maria L.H., Harris, Kate, Clements, Peter, Denning, Chris, Hansen, Arne, Eschenhagen, Thomas

“…Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) are commercially available, and cardiac differentiation established routine. Systematic…”
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Improved Human Embryonic Stem Cell Embryoid Body Homogeneity and Cardiomyocyte Differentiation from a Novel V‐96 Plate Aggregation System Highlights Interline Variability by Burridge, Paul W., Anderson, David, Priddle, Helen, Barbadillo Muñoz, Maria D., Chamberlain, Sarah, Allegrucci, Cinzia, Young, Lorraine E., Denning, Chris

“…Although all human ESC (hESC) lines have similar morphology, express key pluripotency markers, and can differentiate toward primitive germ layers in vitro, the…”
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Discovery of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Multilineage Differentiation by Celiz, Adam D., Smith, James G. W., Patel, Asha K., Hook, Andrew L., Rajamohan, Divya, George, Vinoj T., Flatt, Luke, Patel, Minal J., Epa, Vidana C., Singh, Taranjit, Langer, Robert, Anderson, Daniel G., Allen, Nicholas D., Hay, David C., Winkler, David A., Barrett, David A., Davies, Martyn C., Young, Lorraine E., Denning, Chris, Alexander, Morgan R.

“…A scalable and cost‐effective synthetic polymer substrate that supports robust expansion and subsequent multilineage differentiation of human pluripotent stem…”
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