Search Results - "Dennin, Sean"

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  1. 1
    In Vitro Drug-Drug Interaction Evaluation of GalNAc Conjugated siRNAs Against CYP450 Enzymes and Transporters

    In Vitro Drug-Drug Interaction Evaluation of GalNAc Conjugated siRNAs Against CYP450 Enzymes and Transporters by Ramsden, Diane, Wu, Jing-Tao, Zerler, Brad, Iqbal, Sajida, Jiang, Jim, Clausen, Valerie, Aluri, Krishna, Gu, Yongli, Dennin, Sean, Kim, Joohwan, Chong, Saeho

    Published in Drug metabolism and disposition (01-10-2019)
    “…Small interfering RNAs (siRNAs) represent a new class of medicines that are smaller (∼16,000 Da) than biologic therapeutics (>150,000 Da) but much larger than…”
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    Evaluation of electrophoretic mobility shift assay as a method to determine plasma protein binding of siRNA

    Evaluation of electrophoretic mobility shift assay as a method to determine plasma protein binding of siRNA by Rocca, Carrie, Dennin, Sean, Gu, Yongli, Kim, Joohwan, Chigas, Samantha, Najarian, Diana, Chong, Saeho, Gutierrez, Shannon, Butler, James, Charisse, Klaus, Robbie, Gabriel, Xu, Yuanxin, Brown, Kirk

    Published in Bioanalysis (01-11-2019)
    “…The electrophoretic mobility shift assay (EMSA) was evaluated as an alternative to ultrafiltration (UF) to assess plasma protein binding (PPB) of small…”
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