Search Results - "Denney, Michael L."

Use of Conformationally Restricted Benzamidines as Arginine Surrogates in the Design of Platelet GPIIb-IIIa Receptor Antagonists by Sall, Daniel J, Arfsten, Ann E, Bastian, Jolie A, Denney, Michael L, Harms, Cathy S, McCowan, Jefferson R, Morin, John M, Rose, Jack W, Scarborough, Robert M, Smyth, Mark S, Um, Suzane L, Utterback, Barbara G, Vasileff, Robert T, Wikel, James H, Wyss, Virginia L, Jakubowski, Joseph A

“…The use of 5,6-bicyclic amidines as arginine surrogates in the design of a novel class of potent platelet glycoprotein IIb-IIIa receptor (GPIIb-IIIa)…”
Get full text

Dibasic benzo[ b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 4. SAR studies on the conformationally restricted C3-side chain of hydroxybenzo[ b]thiophenes by Takeuchi, Kumiko, Kohn, Todd J., Sall, Daniel J., Denney, Michael L., McCowan, Jefferson R., Smith, Gerry F., Gifford-Moore, Donetta S.

“…A novel series of benzo[ b]thiophene diamine thrombin inhibitors with a conformationally restricted C3-side chain 3 was investigated. The constrained C3-side…”
Get full text

Dibasic Benzo[b]thiophene Derivatives as a Novel Class of Active Site-Directed Thrombin Inhibitors. 1. Determination of the Serine Protease Selectivity, Structure−Activity Relationships, and Binding Orientation by Sall, Daniel J, Bastian, Jolie A, Briggs, Stephen L, Buben, John A, Chirgadze, Nickolay Y, Clawson, David K, Denney, Michael L, Giera, Deborah D, Gifford-Moore, Donetta S, Harper, Richard W, Hauser, Kenneth L, Klimkowski, Valentine J, Kohn, Todd J, Lin, Ho-Shen, McCowan, Jefferson R, Palkowitz, Alan D, Smith, Gerald F, Takeuchi, Kumiko, Thrasher, Kenneth J, Tinsley, Jennifer M, Utterback, Barbara G, Yan, Sau-Chi B, Zhang, Minsheng

Get full text

Diamino benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 3. Enhancing activity by imposing conformational restriction in the C-4″ side chain1 by Bastian, Jolie A., Chirgadze, Nickolay, Denney, Michael L., Gifford-Moore, Donetta S., Sall, Daniel J., Smith, Gerald F., Wikel, James H.

Get full text

Diamino benzo[ b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 3. Enhancing activity by imposing conformational restriction in the C-4″ side chain 1 by Bastian, Jolie A., Chirgadze, Nickolay, Denney, Michael L., Gifford-Moore, Donetta S., Sall, Daniel J., Smith, Gerald F., Wikel, James H.

“…The preparation and biological evaluation of a series of benzo[ b]thiophene diamine thrombin inhibitors possessing conformationally restricted C-4″ linkers are…”
Get full text

Diamino benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors : 3. enhancing activity by imposing conformational restriction in the C-4 side chain by BASTIAN, J. A, CHIRGADZE, N, DENNEY, M. L, GIFFORD-MOORE, D. S, SALL, D. J, SMITH, G. F, WIKEL, J. H

“…The preparation and biological evaluation of a series of benzo[b]thiophene diamine thrombin inhibitors possessing conformationally restricted C-4" linkers are…”
Get full text

Platelet glycoprotein IIb–IIIa receptor (GPIIb–IIIa) antagonists derived from amidinoindoles by Sall, Daniel J., Arfsten, Ann E., Berry, Dennis R., Denney, Michael L., Harms, Cathy S., McCowan, Jefferson R., Ray, Judith K., Scarborough, Robert M., Um, Suzane L., Utterback, Barbara G., Jakubowski, Joseph A.

“…A series of substituted amidinoindoles have been prepared as mimics of the RGD sequence and were studied as antagonists of the platelet glycoprotein IIb–IIIa…”
Get full text

A convenient synthesis of the thieno[3,2-c]pyridine nucleus by Wikel, James H., Denney, Michael L., Vasileff, Robert T.

“…The unsubstituted thieno[3,2‐c]pyridine ring system was prepared from thiophene‐3‐carboxaldehyde in 4 steps. The sequence is suitable for scale‐up…”
Get full text