Search Results - "Denney, Laura"

Alveolar and lung interstitial macrophages: Definitions, functions, and roles in lung fibrosis by Shi, Ting, Denney, Laura, An, Huazhang, Ho, Ling‐Pei, Zheng, Yuejuan

“…Mϕs are the main innate immune cells in the lung at homeostasis, with important roles in host defence and immune modulation. Alveolar Mϕs (AMs) and…”
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The role of respiratory epithelium in host defence against influenza virus infection by Denney, Laura, Ho, Ling-Pei

“…The respiratory epithelium is the major interface between the environment and the host. Sophisticated barrier, sensing, anti-microbial and immune regulatory…”
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Type 2 innate lymphoid cells in induced sputum from children with severe asthma by Nagakumar, Prasad, MBBS, Denney, Laura, PhD, Fleming, Louise, MD, Bush, Andrew, MD, Lloyd, Clare M., PhD, Saglani, Sejal, MD

“…Children with STRA and a disease control group of children with recurrent lower respiratory tract infections (LRTIs), but no atopy or asthma, undergoing…”
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MAIT cells are activated during human viral infections by van Wilgenburg, Bonnie, Scherwitzl, Iris, Hutchinson, Edward C., Leng, Tianqi, Kurioka, Ayako, Kulicke, Corinna, de Lara, Catherine, Cole, Suzanne, Vasanawathana, Sirijitt, Limpitikul, Wannee, Malasit, Prida, Young, Duncan, Denney, Laura, Moore, Michael D., Fabris, Paolo, Giordani, Maria Teresa, Oo, Ye Htun, Laidlaw, Stephen M., Dustin, Lynn B., Ho, Ling-Pei, Thompson, Fiona M., Ramamurthy, Narayan, Mongkolsapaya, Juthathip, Willberg, Christian B., Screaton, Gavin R., Klenerman, Paul

“…Mucosal-associated invariant T (MAIT) cells are abundant in humans and recognize bacterial ligands. Here, we demonstrate that MAIT cells are also activated…”
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IL-33 promotes airway remodeling in pediatric patients with severe steroid-resistant asthma by Saglani, Sejal, MD, Lui, Stephen, PhD, Ullmann, Nicola, MD, Campbell, Gaynor A., PhD, Sherburn, Rebekah T., MSc, Mathie, Sara A., MSc, Denney, Laura, PhD, Bossley, Cara J., MD(Res), Oates, Timothy, BSc, Walker, Simone A., BSc, Bush, Andrew, MD, Lloyd, Clare M., PhD

“…Background TH 2 cytokines are not responsible for the ongoing symptoms and pathology in children with severe therapy-resistant asthma (STRA). IL-33 induces…”
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Pulmonary Epithelial Cell-Derived Cytokine TGF-β1 Is a Critical Cofactor for Enhanced Innate Lymphoid Cell Function by Denney, Laura, Byrne, Adam J., Shea, Thomas J., Buckley, James S., Pease, James E., Herledan, Gaelle M.F., Walker, Simone A., Gregory, Lisa G., Lloyd, Clare M.

“…Epithelial cells orchestrate pulmonary homeostasis and pathogen defense and play a crucial role in the initiation of allergic immune responses. Maintaining the…”
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Pulmonary ORMDL3 is critical for induction of Alternaria -induced allergic airways disease by Löser, Stephan, MSc, Gregory, Lisa G., PhD, Zhang, Youming, PhD, Schaefer, Katrein, PhD, Walker, Simone A., MSc, Buckley, James, PhD, Denney, Laura, PhD, Dean, Charlotte H., PhD, Cookson, William O.C., MD, DPhil, Moffatt, Miriam F., DPhil, Lloyd, Clare M., PhD

“…Background Genome-wide association studies have identified the ORM (yeast)-like protein isoform 3 ( ORMDL3 ) gene locus on human chromosome 17q to be a highly…”
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Multi-Modal Characterization of Monocytes in Idiopathic Pulmonary Fibrosis Reveals a Primed Type I Interferon Immune Phenotype by Fraser, Emily, Denney, Laura, Antanaviciute, Agne, Blirando, Karl, Vuppusetty, Chaitanya, Zheng, Yuejuan, Repapi, Emmanouela, Iotchkova, Valentina, Taylor, Stephen, Ashley, Neil, St Noble, Victoria, Benamore, Rachel, Hoyles, Rachel, Clelland, Colin, Rastrick, Joseph M D, Hardman, Clare S, Alham, Nasullah K, Rigby, Rachel E, Simmons, Alison, Rehwinkel, Jan, Ho, Ling-Pei

“…Idiopathic pulmonary fibrosis (IPF) is the most severe form of chronic lung fibrosis. Circulating monocytes have been implicated in immune pathology in IPF but…”
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Single cell spatial analysis reveals inflammatory foci of immature neutrophil and CD8 T cells in COVID-19 lungs by Weeratunga, Praveen, Denney, Laura, Bull, Joshua A., Repapi, Emmanouela, Sergeant, Martin, Etherington, Rachel, Vuppussetty, Chaitanya, Turner, Gareth D. H., Clelland, Colin, Woo, Jeongmin, Cross, Amy, Issa, Fadi, de Andrea, Carlos Eduardo, Melero Bermejo, Ignacio, Sims, David, McGowan, Simon, Zurke, Yasemin-Xiomara, Ahern, David J., Gamez, Eddie C., Whalley, Justin, Richards, Duncan, Klenerman, Paul, Monaco, Claudia, Udalova, Irina A., Dong, Tao, Antanaviciute, Agne, Ogg, Graham, Knight, Julian C., Byrne, Helen M., Taylor, Stephen, Ho, Ling-Pei

“…Single cell spatial interrogation of the immune-structural interactions in COVID −19 lungs is challenging, mainly because of the marked cellular infiltrate and…”
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Pivotal Advance: Invariant NKT cells reduce accumulation of inflammatory monocytes in the lungs and decrease immune-pathology during severe influenza A virus infection by Kok, Wai Ling, Denney, Laura, Benam, Kambez, Cole, Suzanne, Clelland, Colin, McMichael, Andrew J., Ho, Ling‐Pei

“…iNKT cells modulate severe influenza by reducing accumulation of inflammatory monocytes in lungs; possibly by targeting infected inflammatory monocytes for…”
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Spatial transcriptomic characterization of COVID-19 pneumonitis identifies immune circuits related to tissue injury by Cross, Amy R, de Andrea, Carlos E, Villalba-Esparza, María, Landecho, Manuel F, Cerundolo, Lucia, Weeratunga, Praveen, Etherington, Rachel E, Denney, Laura, Ogg, Graham, Ho, Ling-Pei, Roberts, Ian Sd, Hester, Joanna, Klenerman, Paul, Melero, Ignacio, Sansom, Stephen N, Issa, Fadi

“…Severe lung damage resulting from COVID-19 involves complex interactions between diverse populations of immune and stromal cells. In this study, we used a…”
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Activation of invariant NKT cells enhances the innate immune response and improves the disease course in influenza A virus infection by Ho, Ling-Pei, Denney, Laura, Luhn, Kerstin, Teoh, Denise, Clelland, Colin, McMichael, Andrew J

“…Invariant NKT (iNKT) cells have an indubitable role in antiviral immunity, although the mechanisms by which these cells exert their functions are not fully…”
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Activation of invariant NKT cells in early phase of experimental autoimmune encephalomyelitis results in differentiation of Ly6Chi inflammatory monocyte to M2 macrophages and improved outcome by Denney, Laura, Kok, Wai Ling, Cole, Suzanne L, Sanderson, Sharon, McMichael, Andrew J, Ho, Ling-Pei

“…Neuropathology in multiple sclerosis is closely linked to presence of macrophages in the CNS. Both M1 (inflammatory) and M2 (alternatively activated,…”
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Pulmonary type-2 innate lymphoid cells in paediatric severe asthma: phenotype and response to steroids by Nagakumar, Prasad, Puttur, Franz, Gregory, Lisa G, Denney, Laura, Fleming, Louise, Bush, Andrew, Lloyd, Clare M, Saglani, Sejal

“…Children with severe therapy-resistant asthma (STRA) have poor control despite maximal treatment, while those with difficult asthma (DA) have poor control from…”
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How the Respiratory Epithelium Senses and Reacts to Influenza Virus by Benam, Kambez H, Denney, Laura, Ho, Ling-Pei

“…The human lung is constantly exposed to the environment and potential pathogens. As the interface between host and environment, the respiratory epithelium has…”
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Pulmonary Epithelial Cell-Derived Cytokine TGF- beta 1 Is a Critical Cofactor for Enhanced Innate Lymphoid Cell Function by Denney, Laura, Byrne, Adam J, Shea, Thomas J, Buckley, James S, Pease, James E, Herledan, Gaelle MF, Walker, Simone A, Gregory, Lisa G, Lloyd, Clare M

“…Epithelial cells orchestrate pulmonary homeostasis and pathogen defense and play a crucial role in the initiation of allergic immune responses. Maintaining the…”
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Reduction of natural killer but not effector CD8 T lymphocytes in three consecutive cases of severe/lethal H1N1/09 influenza A virus infection by Denney, Laura, Aitken, Celia, Li, Chris Ka-Fai, Wilson-Davies, Eleri, Kok, Wai Ling, Clelland, Colin, Rooney, Kevin, Young, Duncan, Dong, Tao, McMichael, Andrew J, Carman, William F, Ho, Ling-Pei

“…The cause of severe disease in some patients infected with pandemic influenza A virus is unclear. We present the cellular immunology profile in the blood, and…”
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Pulmonary environmental cues drive group 2 innate lymphoid cell dynamics in mice and humans by Puttur, Franz, Denney, Laura, Gregory, Lisa G, Vuononvirta, Juho, Oliver, Robert, Entwistle, Lewis J, Walker, Simone A, Headley, Mark B, McGhee, Ewan J, Pease, James E, Krummel, Matthew F, Carlin, Leo M, Lloyd, Clare M

“…Group 2 innate lymphoid cells (ILC2s) are enriched in mucosal tissues (e.g., lung) and respond to epithelial cell-derived cytokines initiating type 2…”
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Regulation of ectodomain shedding of ADAM33 in vitro and in vivo by Davies, Elizabeth R., Denney, Laura, Wandel, Marieke, Lloyd, Clare M., Davies, Donna E., Haitchi, Hans Michael

“…ADAM33 is a transmembrane protein, but a soluble protein containing the metalloprotease domain (sADAM33) has previously been identified in bronchoalveolar…”
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Epithelial-derived TGF-β1 acts as a pro-viral factor in the lung during influenza A infection by Denney, L, Branchett, W, Gregory, L G, Oliver, R A, Lloyd, C M

“…Mucosal surfaces are under constant bombardment from potentially antigenic particles and so must maintain a balance between homeostasis and inappropriate…”
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