Search Results - "Dennery, Phyllis"

Metabolic reprogramming in the pathogenesis of chronic lung diseases, including BPD, COPD, and pulmonary fibrosis by Zhao, Haifeng, Dennery, Phyllis A, Yao, Hongwei

“…The metabolism of nutrient substrates, including glucose, glutamine, and fatty acids, provides acetyl-CoA for the tricarboxylic acid cycle to generate energy,…”
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Signaling function of heme oxygenase proteins by Dennery, Phyllis A

“…Many reports have underscored the importance of the heme degradation pathway that is regulated by heme oxygenase (HO). This reaction releases bile pigments and…”
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Oxidative stress in development: Nature or nurture? by Dennery, Phyllis A.

“…An unavoidable consequence of aerobic respiration is the generation of reactive oxygen species (ROS). These may negatively impact development. Nevertheless, a…”
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Metformin Promotes Angiogenesis in Neonatal Lung Injury: A New Deal of an Old Drug by Dennery, Phyllis A, Yao, Hongwei

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Effects of oxidative stress on embryonic development by Dennery, Phyllis A.

“…Oxygen radicals, or reactive oxygen species (ROS) act as primary or secondary messengers to promote cell growth or death. Many instances demonstrate an…”
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Nuclear Heme Oxygenase-1 (HO-1) Modulates Subcellular Distribution and Activation of Nrf2, Impacting Metabolic and Anti-oxidant Defenses by Biswas, Chhanda, Shah, Nidhi, Muthu, Manasa, La, Ping, Fernando, Amal P., Sengupta, Shaon, Yang, Guang, Dennery, Phyllis A.

“…With oxidative injury as well as in some solid tumors and myeloid leukemia cells, heme oxygenase-1 (HO-1), the anti-oxidant, anti-inflammatory, and…”
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Endothelial-to-mesenchymal transition: Pathogenesis and therapeutic targets for chronic pulmonary and vascular diseases by Lu, Xuexin, Gong, Jiannan, Dennery, Phyllis A., Yao, Hongwei

“…[Display omitted] Endothelial-to-mesenchymal transition (EndoMT) is a process of transdifferentiation where endothelial cells gradually adopt the phenotypic…”
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Even free radicals should follow some rules: A Guide to free radical research terminology and methodology by Forman, Henry Jay, Augusto, Ohara, Brigelius-Flohe, Regina, Dennery, Phyllis A., Kalyanaraman, Balaraman, Ischiropoulos, Harry, Mann, Giovanni E., Radi, Rafael, Roberts, L. Jackson, Vina, Jose, Davies, Kelvin J.A.

“…Free radicals and oxidants are now implicated in physiological responses and in several diseases. Given the wide range of expertise of free radical…”
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Fatty Acid Oxidation Protects against Hyperoxia-induced Endothelial Cell Apoptosis and Lung Injury in Neonatal Mice by Yao, Hongwei, Gong, Jiannan, Peterson, Abigail L, Lu, Xuexin, Zhang, Peng, Dennery, Phyllis A

“…In neonates, hyperoxia or positive pressure ventilation causes continued lung injury characterized by simplified vascularization and alveolarization, which are…”
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Heme oxygenase in neonatal lung injury and repair by Dennery, Phyllis A

“…Premature and sick neonates are often exposed to high concentrations of oxygen, which results in lung injury and long-term adverse consequences. Nevertheless,…”
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Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations by Kalyanaraman, Balaraman, Darley-Usmar, Victor, Davies, Kelvin J.A., Dennery, Phyllis A., Forman, Henry Jay, Grisham, Matthew B., Mann, Giovanni E., Moore, Kevin, Roberts, L. Jackson, Ischiropoulos, Harry

“…The purpose of this position paper is to present a critical analysis of the challenges and limitations of the most widely used fluorescent probes for detecting…”
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Involvement of miRNA-34a regulated Krüppel-like factor 4 expression in hyperoxia-induced senescence in lung epithelial cells by Maeda, Hajime, Yao, Hongwei, Go, Hayato, Huntington, Kelsey E, De Paepe, Monique E, Dennery, Phyllis A

“…Premature infants, subjected to supplemental oxygen and mechanical ventilation, may develop bronchopulmonary dysplasia, a chronic lung disease characterized by…”
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Metabolic dysregulation in bronchopulmonary dysplasia: Implications for identification of biomarkers and therapeutic approaches by Yue, Li, Lu, Xuexin, Dennery, Phyllis A., Yao, Hongwei

“…Bronchopulmonary dysplasia (BPD) is a common chronic lung disease in premature infants. Accumulating evidence shows that dysregulated metabolism of glucose,…”
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Endothelial to mesenchymal transition during neonatal hyperoxia‐induced pulmonary hypertension by Gong, Jiannan, Feng, Zihang, Peterson, Abigail L, Carr, Jennifer F, Vang, Alexander, Braza, Julie, Choudhary, Gaurav, Dennery, Phyllis A, Yao, Hongwei

“…Bronchopulmonary dysplasia (BPD), a chronic lung disease in premature infants, results from mechanical ventilation and hyperoxia, amongst other factors…”
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Heme Oxygenase-1 Protein Localizes to the Nucleus and Activates Transcription Factors Important in Oxidative Stress by Lin, Qing, Weis, Sebastian, Yang, Guang, Weng, Yi-Hao, Helston, Rachel, Rish, Kimberly, Smith, Ann, Bordner, Jessica, Polte, Tobias, Gaunitz, Frank, Dennery, Phyllis A.

“…Heme oxygenase-1 (HO-1), the rate-limiting enzyme in heme degradation, is an integral membrane protein of the smooth endoplasmic reticulum. However, we…”
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Heme Oxygenase 1 and 2 Differentially Regulate Glucose Metabolism and Adipose Tissue Mitochondrial Respiration: Implications for Metabolic Dysregulation by Yao, Hongwei, Peterson, Abigail L, Li, Jie, Xu, Haiyan, Dennery, Phyllis A

“…Heme oxygenase (HO) consists of inducible (HO-1) and constitutive (HO-2) isoforms that are encoded by and genes, respectively. As an anti-inflammatory and…”
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Timing and cell specificity of senescence drives postnatal lung development and injury by Yao, Hongwei, Wallace, Joselynn, Peterson, Abigail L., Scaffa, Alejandro, Rizal, Salu, Hegarty, Katy, Maeda, Hajime, Chang, Jason L., Oulhen, Nathalie, Kreiling, Jill A., Huntington, Kelsey E., De Paepe, Monique E., Barbosa, Guilherme, Dennery, Phyllis A.

“…Senescence causes age-related diseases and stress-related injury. Paradoxically, it is also essential for organismal development. Whether senescence…”
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Expression level and subcellular localization of heme oxygenase-1 modulates its cytoprotective properties in response to lung injury: a mouse model by Namba, Fumihiko, Go, Hayato, Murphy, Jennifer A, La, Ping, Yang, Guang, Sengupta, Shaon, Fernando, Amal P, Yohannes, Mekdes, Biswas, Chhanda, Wehrli, Suzanne L, Dennery, Phyllis A

“…Premature infants exposed to hyperoxia suffer acute and long-term pulmonary consequences. Nevertheless, neonates survive hyperoxia better than adults. The…”
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Upregulating carnitine palmitoyltransferase 1 attenuates hyperoxia-induced endothelial cell dysfunction and persistent lung injury by Chang, Jason L, Gong, Jiannan, Rizal, Salu, Peterson, Abigail L, Chang, Julia, Yao, Chenrui, Dennery, Phyllis A, Yao, Hongwei

“…Abstract Background Bronchopulmonary dysplasia (BPD) is a chronic lung disease in premature infants that may cause long-term lung dysfunction. Accumulating…”
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Loss of the transcriptional repressor Rev-erbα upregulates metabolism and proliferation in cultured mouse embryonic fibroblasts by Gillis, Sean P., Yao, Hongwei, Rizal, Salu, Maeda, Hajime, Chang, Julia, Dennery, Phyllis A.

“…The transcriptional repressor Rev-erbα is known to down-regulate fatty acid metabolism and gluconeogenesis gene expression. In animal models, disruption of…”
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