Search Results - "Dennehy, Kevin M"

CLEC9A Is a Novel Activation C-type Lectin-like Receptor Expressed on BDCA3+ Dendritic Cells and a Subset of Monocytes by Huysamen, Cristal, Willment, Janet A., Dennehy, Kevin M., Brown, Gordon D.

“…We describe here the first characterization of CLEC9A, a group V C-type lectin-like receptor located in the “Dectin-1 cluster” of related receptors, which are…”
Get full text

Reciprocal regulation of IL-23 and IL-12 following co-activation of Dectin-1 and TLR signaling pathways by Dennehy, Kevin M, Willment, Janet A, Williams, David L, Brown, Gordon D

“…Recognition of microbial products by germ-line-encoded PRR initiates immune responses, but how PRR mediate specific host responses to infectious agents is…”
Get full text

The role of the β-glucan receptor Dectin-1 in control of fungal infection by Dennehy, Kevin M., Brown, Gordon D.

“…During fungal infection, a variety of receptors initiates immune responses, including TLR and the β‐glucan receptor Dectin‐1. TLR recognition of fungal ligands…”
Get full text

The C-type Lectin Receptor CLECSF8 (CLEC4D) Is Expressed by Myeloid Cells and Triggers Cellular Activation through Syk Kinase by Graham, Lisa M., Gupta, Vandana, Schafer, Georgia, Reid, Delyth M., Kimberg, Matti, Dennehy, Kevin M., Hornsell, William G., Guler, Reto, Campanero-Rhodes, Maria A., Palma, Angelina S., Feizi, Ten, Kim, Stella K., Sobieszczuk, Peter, Willment, Janet A., Brown, Gordon D.

“…Background: C-type lectins play important roles in immunity and homeostasis. Results: CLECSF8 is expressed on neutrophils and monocytes and can mediate…”
Get full text

Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors by Dennehy, Kevin M, Ferwerda, Gerben, Faro-Trindade, Inês, Pyż, Elwira, Willment, Janet A, Taylor, Philip R, Kerrigan, Ann, Tsoni, S. Vicky, Gordon, Siamon, Meyer-Wentrup, Friederike, Adema, Gosse J, Kullberg, Bart-Jan, Schweighoffer, Edina, Tybulewicz, Victor, Mora-Montes, Hector M, Gow, Neil A.R, Williams, David L, Netea, Mihai G, Brown, Gordon D

“…Recognition of microbial components by germ-line encoded pattern recognition receptors (PRR) initiates immune responses to infectious agents. We and others…”
Get full text

Targeted in-vitro-stimulation reveals highly proliferative multi-virus-specific human central memory T cells as candidates for prophylactic T cell therapy by Faist, Benjamin, Schlott, Fabian, Stemberger, Christian, Dennehy, Kevin M, Krackhardt, Angela, Verbeek, Mareike, Grigoleit, Götz U, Schiemann, Matthias, Hoffmann, Dieter, Dick, Andrea, Martin, Klaus, Hildebrandt, Martin, Busch, Dirk H, Neuenhahn, Michael

“…Adoptive T cell therapy (ACT) has become a treatment option for viral reactivations in patients undergoing allogeneic hematopoietic stem cell transplantation…”
Get full text

Cutting edge: NKp80 uses an atypical hemi-ITAM to trigger NK cytotoxicity by Dennehy, Kevin M, Klimosch, Sascha N, Steinle, Alexander

“…The human NK cell receptor NKp80 stimulates cytotoxicity upon engagement of its genetically linked ligand AICL. However, the mechanisms underlying…”
Get full text

CLEC-2 Is a Phagocytic Activation Receptor Expressed on Murine Peripheral Blood Neutrophils by Kerrigan, Ann M, Dennehy, Kevin M, Mourao-Sa, Diego, Faro-Trindade, Ines, Willment, Janet A, Taylor, Philip R, Eble, Johannes A, Reis e Sousa, Caetano, Brown, Gordon D

“…CLEC-2 is a member of the "dectin-1 cluster" of C-type lectin-like receptors and was originally thought to be restricted to platelets. In this study, we…”
Get full text

Interaction of C-type lectin-like receptors NKp65 and KACL facilitates dedicated immune recognition of human keratinocytes by Spreu, Jessica, Kuttruff, Sabrina, Stejfova, Veronika, Dennehy, Kevin M, Schittek, Birgit, Steinle, Alexander

“…Many well-known immune-related C-type lectin-like receptors (CTLRs) such as NKG2D, CD69, and the Ly49 receptors are encoded in the natural killer gene complex…”
Get full text

Rapid regulatory T-cell response prevents cytokine storm in CD28 superagonist treated mice by Gogishvili, Tea, Langenhorst, Daniela, Lühder, Fred, Elias, Fernando, Elflein, Karin, Dennehy, Kevin M, Gold, Ralf, Hünig, Thomas

“…Superagonistic CD28-specific monoclonal antibodies (CD28SA) are highly effective activators of regulatory T-cells (Treg cells) in rats, but a first-in-man…”
Get full text

Comparison of the Development of SARS-Coronavirus-2-Specific Cellular Immunity, and Central Memory CD4+ T-Cell Responses Following Infection versus Vaccination by Dennehy, Kevin M, Löll, Eva, Dhillon, Christine, Classen, Johanna-Maria, Warm, Tobias D, Schuierer, Lukas, Hyhlik-Dürr, Alexander, Römmele, Christoph, Gosslau, Yvonne, Kling, Elisabeth, Hoffmann, Reinhard

“…Memory T-cell responses following infection with coronaviruses are reportedly long-lived and provide long-term protection against severe disease. Whether…”
Get full text

Human MICL (CLEC12A) is differentially glycosylated and is down‐regulated following cellular activation by Marshall, Andrew S. J., Willment, Janet A., Pyż, Elwira, Dennehy, Kevin M., Reid, Delyth M., Dri, Pietro, Gordon, Siamon, Wong, Simon Y. C., Brown, Gordon D.

“…C‐type lectins are the most diverse and prevalent lectin family in immunity. Particular interest has recently been attracted by the C‐type lectin‐like…”
Get full text

extracellular domains of FasL and Fas are sufficient for the formation of supramolecular FasL-Fas clusters of high stability by Henkler, Frank, Behrle, Eva, Dennehy, Kevin M, Wicovsky, Andreas, Peters, Nathalie, Warnke, Clemens, Pfizenmaier, Klaus, Wajant, Harald

“…Using fluorescent variants of Fas and FasL, we show that membrane FasL and Fas form supramolecular clusters that are of flexible shape, but nevertheless stable…”
Get full text

Dectin-1 is required for β-glucan recognition and control of fungal infection by Findon, Helen, Steele, Chad, Taylor, Philip R, Willment, Janet A, Haynes, Ken, Brown, Gordon D, Rosas, Marcela, Gordon, Siamon, Tsoni, S Vicky, Dennehy, Kevin M, Botto, Marina

“…Beta-glucan is one of the most abundant polysaccharides in fungal pathogens, yet its importance in antifungal immunity is unclear. Here we show that deficiency…”
Get full text

Impact of age and gender on lymphocyte subset counts in patients with COVID‐19 by Löhr, Phillip, Schiele, Stefan, Arndt, Tim Tobias, Grützner, Stefanie, Claus, Rainer, Römmele, Christoph, Müller, Gernot, Schmid, Christoph, Dennehy, Kevin M., Rank, Andreas

“…In symptomatic patients with acute Coronavirus disease 2019 (COVID‐19), lymphocytopenia is one of the most prominent laboratory findings. However, to date age…”
Get full text

Measuring Antiviral Capacity of T Cell Responses to Adenovirus by Keib, Anna, Mei, Ya-Fang, Cicin-Sain, Luka, Busch, Dirk H, Dennehy, Kevin M

“…Adenoviruses are a major cause of infectious mortality in children following allogeneic hematopoietic stem cell transplantation, with adoptive transfer of…”
Get full text

One Year after Mild COVID-19: The Majority of Patients Maintain Specific Immunity, But One in Four Still Suffer from Long-Term Symptoms by Rank, Andreas, Tzortzini, Athanasia, Kling, Elisabeth, Schmid, Christoph, Claus, Rainer, Löll, Eva, Burger, Roswitha, Römmele, Christoph, Dhillon, Christine, Müller, Katharina, Girl, Philipp, Hoffmann, Reinhard, Grützner, Stefanie, Dennehy, Kevin M.

“…After COVID-19, some patients develop long-term symptoms. Whether such symptoms correlate with immune responses, and how long immunity persists, is not yet…”
Get full text

Protective T cell receptor identification for orthotopic reprogramming of immunity in refractory virus infections by Stief, Tanja A., Kaeuferle, Theresa, Müller, Thomas R., Döring, Michaela, Jablonowski, Lena M., Schober, Kilian, Feucht, Judith, Dennehy, Kevin M., Willier, Semjon, Blaeschke, Franziska, Handgretinger, Rupert, Lang, Peter, Busch, Dirk H., Feuchtinger, Tobias

“…Viral infections cause life-threatening disease in immunocompromised patients and especially following transplantation. T cell receptor (TCR) engineering…”
Get full text

Presentation of a Conserved Adenoviral Epitope on HLA-C0702 Allows Evasion of Natural Killer but Not T Cell Responses by Keib, Anna, Günther, Patrick S, Faist, Benjamin, Halenius, Anne, Busch, Dirk H, Neuenhahn, Michael, Jahn, Gerhard, Dennehy, Kevin M

“…Infection with adenovirus is a major cause of infectious mortality in children following hematopoietic stem-cell transplantation. While adoptive transfer of…”
Get more information

Human CD8(+) T Cells Target Multiple Epitopes in Respiratory Syncytial Virus Polymerase by Burbulla, Daniel, Günther, Patrick S, Peper, Janet K, Jahn, Gerhard, Dennehy, Kevin M

“…Respiratory syncytial virus (RSV) infection is a serious health problem in young children, immunocompromised patients, and the elderly. The development of…”
Get more information