Laboratory and Imaging Evaluation of Cardiac Involvement in Patients with Post-Acute COVID-19

Laboratory and Imaging Evaluation of Cardiac Involvement in Patients with Post-Acute COVID-19

In the post-acute COVID-19 syndrome, many patients suffer from palpitations, effort-associated fatigue, and even sudden death. The mechanism of heart involvement in this syndrome is uncertain. The main purpose of the study was to identify possible cardiac involvement causes in patients with post-acu...

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Bibliographic Details
Published in:International journal of general medicine Vol. 14; pp. 4977 - 4985
Main Authors: Sarıçam, Ersin, Dursun, Ali Doğan, Türkmen Sarıyıldız, Gülçin, Can, Nalan, Bozkurt, Engin, Gönüllü, Uğur, Basay, Nihal, Türkmen, Meral, Denli, Abdülaziz, Ünlü, Mustafa
Format: Journal Article
Language:English
Published: New Zealand Dove Medical Press Limited 2021
Taylor & Francis Ltd
Dove
Dove Medical Press
Subjects:
Acute coronary syndromes
Asymptomatic
Biomarkers
Cardiac arrhythmia
cardiac involvement
Cardiovascular disease
Care and treatment
Comorbidity
Coronaviruses
COVID-19
Diagnosis
Disease transmission
Edema
Ejection fraction
Fatigue
Gadobutrol
Heart
imaging
Laboratories
laboratory tests
Myocarditis
Nitric oxide
Original Research
Oxidative stress
Palpitation
Patients
PET imaging
post-acute covid-19
Scars
Severe acute respiratory syndrome
Sinuses
Statistical analysis
Tomography
Values
Canada
United States > US
laboratory tests
post-acute COVID-19
cardiac involvement
imaging
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Summary:In the post-acute COVID-19 syndrome, many patients suffer from palpitations, effort-associated fatigue, and even sudden death. The mechanism of heart involvement in this syndrome is uncertain. The main purpose of the study was to identify possible cardiac involvement causes in patients with post-acute COVID-19 by using biomarkers such as NT-proBNP and nitric oxide (NO) and cardiac imaging modalities. In this cross-sectional study, a total of 105 participants were included according to the existence of symptoms, and 40 of these participants were asymptomatic patients. The ages of the participants ranged from 20 to 50 years. All patients were healthy before COVID-19. The symptoms were defined as palpitations and/or fatigue association with exercise in post-acute COVID-19 term. The comparison of the two groups was made by using biochemical parameters (NT-proBNP, Troponin I, NO) and imaging techniques (echocardiography, cardiovascular magnetic resonance (CMR) and cardiac positron emission tomography (PET)). The symptomatic patients had higher NT-proBNP levels compared with asymptomatic patients (132.30±35.15; 76.86±16.79, respectively; p < 0.001). Interestingly, the symptomatic patients had lower NO levels than asymptomatic patients (9.20±3.08; 16.15±6.02, respectively; p < 0.001). Echocardiography and CMR were normal. However, we found regional increased 18F-FDG uptake on cardiac PET to be compatible with myocardial fatigue. We found elevated NT-proNBP levels, low serum NO levels, and increased 18F-FDG uptake on cardiac PET in post-acute COVID syndrome. Cardiac PET could replace or be added to CMR for detecting subtle subacute/chronic myocarditis. The follow-up of patients with post-acute COVID-19 could target the possibility of risk of heart failure.
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ISSN:1178-7074
1178-7074
DOI:10.2147/IJGM.S321156