Search Results - "Denk, U"

Development of CLL in the TCL1 transgenic mouse model is associated with severe skewing of the T-cell compartment homologous to human CLL by Hofbauer, J Piñón, Heyder, C, Denk, U, Kocher, T, Holler, C, Trapin, D, Asslaber, D, Tinhofer, I, Greil, R, Egle, A

“…Chronic lymphocytic leukemia (CLL) cells require complex microenvironmental and immunologic interactions to survive and proliferate. Such interactions might be…”
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Role of interleukin-1 and its antagonism of hepatic stellate cell proliferation and liver fibrosis in the Abcb4-/- mouse model by Reiter, Florian P, Wimmer, Ralf, Wottke, Lena, Artmann, Renate, Nagel, Jutta M, Carranza, Manuel O, Mayr, Doris, Rust, Christian, Fickert, Peter, Trauner, Michael, Gerbes, Alexander L, Hohenester, Simon, Denk, Gerald U

“…AIM: To study the interleukin-1（IL-1） pathway as a therapeutic target for liver fibrosis in vitro and in vivo using the ATP-binding cassette transporter…”
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Multidrug resistance-associated protein 4 is up-regulated in liver but down-regulated in kidney in obstructive cholestasis in the rat by Denk, Gerald U, Soroka, Carol J, Takeyama, Yasuaki, Chen, Wen-Sheng, Schuetz, John D, Boyer, James L

“…Multidrug resistance-associated protein 4 (Mrp4, ABCC4) transports cyclic nucleotides, anti-retroviral compounds, and sulfated bile acids. Mrp4 expression is…”
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CD4+ T cells, but not non-classical monocytes, are dispensable for the development of chronic lymphocytic leukemia in the TCL1-tg murine model by Kocher, T, Asslaber, D, Zaborsky, N, Flenady, S, Denk, U, Reinthaler, P, Ablinger, M, Geisberger, R, Bauer, J W, Seiffert, M, Hartmann, T N, Greil, R, Egle, A, Piñón Hofbauer, J

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Actinomycin D induces p53-independent cell death and prolongs survival in high-risk chronic lymphocytic leukemia by Merkel, O, Wacht, N, Sifft, E, Melchardt, T, Hamacher, F, Kocher, T, Denk, U, Hofbauer, J P, Egle, A, Scheideler, M, Schlederer, M, Steurer, M, Kenner, L, Greil, R

“…Chronic lymphocytic leukemia (CLL) is the most prevalent lymphoid malignancy in the elderly of the Western world. Although treatment options have improved over…”
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Plasma separation and anion adsorption transiently relieve intractable pruritus in primary biliary cirrhosis by Pusl, Thomas, Denk, Gerald U., Parhofer, Klaus G., Beuers, Ulrich

“…Pruritus can be a severely disabling symptom in patients with primary biliary cirrhosis who do not respond to treatment with ursodeoxycholic acid, anion…”
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Down‐regulation of the organic cation transporter 1 of rat liver in obstructive cholestasis by Denk, Gerald U., Soroka, Carol J., Mennone, Albert, Koepsell, Hermann, Beuers, Ulrich, Boyer, James L.

“…The liver plays a major role in biotransformation and elimination of various therapeutic agents and xenobiotics, many of which are organic cations and…”
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Taurolithocholic Acid Exerts Cholestatic Effects via Phosphatidylinositol 3-Kinase-dependent Mechanisms in Perfused Rat Livers and Rat Hepatocyte Couplets by Beuers, Ulrich, Denk, Gerald U, Soroka, Carol J, Wimmer, Ralf, Rust, Christian, Paumgartner, Gustav, Boyer, James L

“…Taurolithocholic acid (TLCA) is a potent cholestatic agent. Our recent work suggested that TLCA impairs hepatobiliary exocytosis, insertion of transport…”
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Alternaria alternata NADP-dependent mannitol dehydrogenase is an important fungal allergen by Schneider, P. B., Denk, U., Breitenbach, M., Richter, K., Schmid-Grendelmeier, P., Nobbe, S., Himly, M., Mari, A., Ebner, C., Simon-Nobbe, B.

“…Summary Background Alternaria alternata is one of the most important allergenic fungi worldwide. Mannitol dehydrogenase (MtDH) has previously been shown to be…”
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ABCB4 deficiency: A family saga of early onset cholelithiasis, sclerosing cholangitis and cirrhosis and a novel mutation in the ABCB4 gene by Denk, Gerald U., Bikker, Hennie, Lekanne dit Deprez, Ronald H., Terpstra, Valeska, Van Der Loos, Chris, Beuers, Ulrich, Rust, Christian, Pusl, Thomas

“…Gallstones are very common. However, there is a small group of patients with low phospholipid‐associated cholelithiasis (LPAC) that is characterized by…”
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Genetic inactivation of the Fanconi anemia gene FANCC identified in the hepatocellular carcinoma cell line HuH-7 confers sensitivity towards DNA-interstrand crosslinking agents by Palagyi, Andreas, Neveling, Kornelia, Plinninger, Ursula, Ziesch, Andreas, Targosz, Bianca-Sabrina, Denk, Gerald U, Ochs, Stephanie, Rizzani, Antonia, Meier, Daniel, Thasler, Wolfgang E, Hanenberg, Helmut, De Toni, Enrico N, Bassermann, Florian, Schäfer, Claus, Göke, Burkhard, Schindler, Detlev, Gallmeier, Eike

“…Inactivation of the Fanconi anemia (FA) pathway through defects in one of 13 FA genes occurs at low frequency in various solid cancer entities among the…”
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Hepatitis surface antigen clearance in a woman with liver cirrhosis and concomitant autoimmune hepatitis under immunosuppressive therapy by Reiter, Florian P., Denk, Gerald U., Grüner, Norbert H., Kleiss, Philipp, Rust, Christian

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Association of HDL deficiency with a novel mutation in the ABCA1 gene by Denk, G U, Aslanidis, C, Schmitz, G, Parhofer, K G, Pusl, T

“…The ATP-binding cassette transporter A1 (ABCA1) is a membrane-bound protein that is abundant in macrophages and is essential for the first step of reverse…”
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Etiologies and Outcomes of Acute Liver Failure in Germany by Hadem, Johannes, Tacke, Frank, Bruns, Tony, Langgartner, Julia, Strnad, Pavel, Denk, Gerald U, Fikatas, Panagiotis, Manns, Michael P, Hofmann, Wolf P, Gerken, Guido, Grünhage, Frank, Umgelter, Andreas, Trautwein, Christian, Canbay, Ali

“…Background & Aims Acute liver failure (ALF) is a severe form of acute liver injury that can progress to multiple organ failure. We investigated causes and…”
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1,25-(OH)2-vitamin D3 prevents activation of hepatic stellate cells in vitro and ameliorates inflammatory liver damage but not fibrosis in the Abcb4−/− model by Reiter, Florian P., Hohenester, Simon, Nagel, Jutta M., Wimmer, Ralf, Artmann, Renate, Wottke, Lena, Makeschin, Marie-Christine, Mayr, Doris, Rust, Christian, Trauner, Michael, Denk, Gerald U.

“…Vitamin D3-deficiency is common in patients with chronic liver-disease and may promote disease progression. Vitamin D3-administration has thus been proposed as…”
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A comparison of gene expression in mouse liver and kidney in obstructive cholestasis utilizing high-density oligonucleotide microarray technology by Denk, Gerald U, Cai, Shi-Ying, Chen, Wen-Sheng, Lin, Aiping, Soroka, Carol J, Boyer, James L

“…To assess the effects of obstructive cholestasis on a wider range of gene expression using microarray technology. Male C57BL/6J mice underwent common bile duct…”
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Tauroursodeoxycholic acid exerts anticholestatic effects by a cooperative cPKC alpha-/PKA-dependent mechanism in rat liver by Wimmer, R, Hohenester, S, Pusl, T, Denk, G U, Rust, C, Beuers, U

“…Ursodeoxycholic acid (UDCA) exerts anticholestatic effects in part by protein kinase C (PKC)-dependent mechanisms. Its taurine conjugate, TUDCA, is a cPKC…”
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Conjugation is essential for the anticholestatic effect of NorUrsodeoxycholic acid in taurolithocholic acid–induced cholestasis in rat liver by Denk, Gerald U., Maitz, Silvia, Wimmer, Ralf, Rust, Christian, Invernizzi, Pietro, Ferdinandusse, Sacha, Kulik, Wim, Fuchsbichler, Andrea, Fickert, Peter, Trauner, Michael, Hofmann, Alan F., Beuers, Ulrich

“…NorUDCA (24‐norursodeoxycholic acid), the C23‐homolog of ursodeoxycholic acid (UDCA), showed remarkable therapeutic effects in cholestatic Mdr2 (Abcb4)…”
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Physiological hypoxia prevents bile salt-induced apoptosis in human and rat hepatocytes by Hohenester, Simon, Vennegeerts, Timo, Wagner, Michaela, Wimmer, Ralf, Drolle, Heidrun, Rieger, Christina, Denk, Gerald U., Rust, Christian, Fiegl, Michael

“…Background & Aims Hydrophobic bile salts such as glycochenodeoxycholate (GCDC) accumulate in cholestatic liver disease and induce hepatocellular apoptosis,…”
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Alternaria alternata mannitol dehydrogenase, a fungal allergen by Schneider, P.B., Denk, U., Ebner, C., Breitenbach, M., Simon-Nobbe, B.

“…Mannitol dehydrogenase (MtDH) has previously been shown to be the major allergen of Cladosporium herbarum. Since cross-reactivity has been demonstrated for…”
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