Search Results - "Denizot, Claire"

Evaluation of P-Glycoprotein Inhibitory Potential Using a Rhodamine 123 Accumulation Assay by Jouan, Elodie, Le Vée, Marc, Mayati, Abdullah, Denizot, Claire, Parmentier, Yannick, Fardel, Olivier

“…In vitro evaluation of P-glycoprotein (P-gp) inhibitory potential is now a regulatory issue during drug development, in order to predict clinical inhibition of…”
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Inhibition of Human Drug Transporter Activities by the Pyrethroid Pesticides Allethrin and Tetramethrin by Chedik, Lisa, Bruyere, Arnaud, Le Vee, Marc, Stieger, Bruno, Denizot, Claire, Parmentier, Yannick, Potin, Sophie, Fardel, Olivier

“…Pyrethroids are widely-used chemical insecticides, to which humans are commonly exposed, and known to alter functional expression of drug metabolizing enzymes…”
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Inhibition of organic cation transporter 3 activity by tyrosine kinase inhibitors by Alim, Karima, Moreau, Amélie, Bruyère, Arnaud, Jouan, Elodie, Denizot, Claire, Nies, Anne T., Parmentier, Yannick, Fardel, Olivier

“…Organic cation transporter (OCT) 3 (SLC22A3) is a widely expressed drug transporter, handling notably metformin and platinum derivatives, as well as endogenous…”
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Protein Kinases C-Mediated Regulations of Drug Transporter Activity, Localization and Expression by Mayati, Abdullah, Moreau, Amélie, Le Vée, Marc, Stieger, Bruno, Denizot, Claire, Parmentier, Yannick, Fardel, Olivier

“…Drug transporters are now recognized as major actors in pharmacokinetics, involved notably in drug-drug interactions and drug adverse effects. Factors that…”
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The mitochondrial fluorescent dye rhodamine 123 is a high-affinity substrate for organic cation transporters (OCTs) 1 and 2 by Jouan, Elodie, Le Vee, Marc, Denizot, Claire, Da Violante, Georges, Fardel, Olivier

“…Rhodamine 123 is a fluorescent cationic dye commonly used as a mitochondrial probe and known or suspected to be transported by certain drug membrane…”
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Alteration of human hepatic drug transporter activity and expression by cigarette smoke condensate by Sayyed, Katia, Vee, Marc L.E, Abdel-Razzak, Ziad, Jouan, Elodie, Stieger, Bruno, Denizot, Claire, Parmentier, Yannick, Fardel, Olivier

“…Graphical abstract…”
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Exposure of human cerebral microvascular endothelial cells hCMEC/D3 to laminar shear stress induces vascular protective responses by Choublier, Nina, Taghi, Meryam, Menet, Marie-Claude, Le Gall, Morgane, Bruce, Johanna, Chafey, Philippe, Guillonneau, François, Moreau, Amélie, Denizot, Claire, Parmentier, Yannick, Nakib, Samir, Borderie, Didier, Bouzinba-Segard, Haniaa, Couraud, Pierre-Olivier, Bourdoulous, Sandrine, Declèves, Xavier

“…Endothelial cells (ECs) are constantly submitted in vivo to hemodynamical forces derived from the blood circulation, including shear stress (SS). ECs are able…”
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Protein Kinase C-Independent Inhibition of Organic Cation Transporter 1 Activity by the Bisindolylmaleimide Ro 31-8220 by Mayati, Abdullah, Bruyere, Arnaud, Moreau, Amélie, Jouan, Elodie, Denizot, Claire, Parmentier, Yannick, Fardel, Olivier

“…Ro 31-8220 is a potent protein kinase C (PKC) inhibitor belonging to the chemical class of bisindolylmaleimides (BIMs). Various PKC-independent effects of Ro…”
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Evaluation of Drug Biliary Excretion Using Sandwich-Cultured Human Hepatocytes by Fardel, Olivier, Moreau, Amélie, Le Vée, Marc, Denizot, Claire, Parmentier, Yannick

“…Evaluation of hepatobiliary transport of drugs is an important challenge, notably during the development of new molecular identities. In this context,…”
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Drug Transporter Expression and Activity in Human Hepatoma HuH-7 Cells by Jouan, Elodie, Le Vée, Marc, Denizot, Claire, Parmentier, Yannick, Fardel, Olivier

“…Human hepatoma cells may represent a valuable alternative to the use of human hepatocytes for studying hepatic drug transporters, which is now a regulatory…”
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mRNA Expression and Activity of Nucleoside Transporters in Human Hepatoma HepaRG Cells by Mayati, Abdullah, Moreau, Amélie, Jouan, Elodie, Febvre-James, Marie, Denizot, Claire, Parmentier, Yannick, Fardel, Olivier

“…The HepaRG cell line is a highly differentiated human hepatoma cell line, displaying the expression of various drug transporters. However, functional…”
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CHARACTERIZATION OF MICROSOMAL CYTOCHROME P450-DEPENDENT MONOOXYGENASES IN THE RAT OLFACTORY MUCOSA by MINN, Anne-Laure, PELCZAR, Hélène, DENIZOT, Claire, MARTINET, Michel, HEYDEL, Jean-Marie, WALTHER, Bernard, MINN, Alain, GOUDONNET, Hervé, ARTUR, Yves

“…Nasal administration of a drug ensures therapeutic action by rapid systemic absorption and/or the entry of some molecules into the brain through different…”
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Prediction of renal transporter-mediated drug-drug interactions for a drug which is an OAT substrate and inhibitor using PBPK modelling by Ball, Kathryn, Jamier, Tanguy, Parmentier, Yannick, Denizot, Claire, Mallier, Agnes, Chenel, Marylore

“…A PBPK modelling approach was used to predict organic anion transporter (OAT) mediated drug-drug interactions involving S44121, a substrate and an inhibitor of…”
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New insights in the in vitro characterisation and molecular modelling of the P-glycoprotein inhibitory promiscuity by Bocci, Giovanni, Moreau, Amélie, Vayer, Philippe, Denizot, Claire, Fardel, Olivier, Parmentier, Yannick

“…The presence of several binding sites for both substrates and inhibitors is yet a poorly explored thematic concerning the assessment of the drug-drug…”
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The Competitive Counterflow Assay for Identifying Drugs Transported by Solute Carriers: Principle, Applications, Challenges/Limits, and Perspectives by Fardel, Olivier, Moreau, Amélie, Carteret, Jennifer, Denizot, Claire, Le Vée, Marc, Parmentier, Yannick

“…The identification of substrates for solute carriers (SLCs) handling drugs is an important challenge, owing to the major implication of these plasma membrane…”
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Functional and targeted proteomics characterization of a human primary endothelial cell model of the blood-brain barrier (BBB) for drug permeability studies by Gomez-Zepeda, David, Perrière, Nicolas, Glacial, Fabienne, Taghi, Meryam, Chhuon, Cérina, Scherrmann, Jean-Michel, Sergent, Philippe, Moreau, Amélie, Denizot, Claire, Parmentier, Yannick, Cisternino, Salvatore, Decleves, Xavier, Menet, Marie-Claude

“…The blood-brain barrier (BBB) protects the brain from toxins but hinders the penetration of neurotherapeutic drugs. Therefore, the blood-to-brain permeability…”
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Differential Inhibition of Equilibrative Nucleoside Transporter 1 (ENT1) Activity by Tyrosine Kinase Inhibitors by Jouan, Elodie, Moreau, Amélie, Bruyere, Arnaud, Alim, Karima, Denizot, Claire, Parmentier, Yannick, Fardel, Olivier

“…Background and Objectives Equilibrative nucleoside transporter (ENT) 1 is a widely-expressed drug transporter, handling nucleoside analogues as well as…”
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Functional polarization of human hepatoma HepaRG cells in response to forskolin by Mayati, Abdullah, Moreau, Amélie, Le Vée, Marc, Bruyère, Arnaud, Jouan, Elodie, Denizot, Claire, Parmentier, Yannick, Fardel, Olivier

“…HepaRG is an original human hepatoma cell line, acquiring highly differentiated hepatic features when exposed to dimethylsulfoxide (DMSO). To search…”
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beta 2-adrenergic receptor-mediated in vitro regulation of human hepatic drug transporter expression by epinephrine by Mayati, Abdullah, Moreau, Amélie, Denizot, Claire, Stieger, Bruno, Parmentier, Yannick, Fardel, Olivier

“…The catecholamine epinephrine is known to repress expression of hepatic drug metabolizing enzymes such as cytochromes P-450. The present study was designed to…”
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β2-adrenergic receptor-mediated in vitro regulation of human hepatic drug transporter expression by epinephrine by Mayati, Abdullah, Moreau, Amélie, Denizot, Claire, Stieger, Bruno, Parmentier, Yannick, Fardel, Olivier

“…The catecholamine epinephrine is known to repress expression of hepatic drug metabolizing enzymes such as cytochromes P-450. The present study was designed to…”
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