Search Results - "Denise Appel, C"

Deficiency of terminal ADP-ribose protein glycohydrolase TARG1/C6orf130 in neurodegenerative disease by Sharifi, Reza, Morra, Rosa, Denise Appel, C, Tallis, Michael, Chioza, Barry, Jankevicius, Gytis, Simpson, Michael A, Matic, Ivan, Ozkan, Ege, Golia, Barbara, Schellenberg, Matthew J, Weston, Ria, Williams, Jason G, Rossi, Marianna N, Galehdari, Hamid, Krahn, Juno, Wan, Alexander, Trembath, Richard C, Crosby, Andrew H, Ahel, Dragana, Hay, Ron, Ladurner, Andreas G, Timinszky, Gyula, Williams, R Scott, Ahel, Ivan

“…Adenosine diphosphate (ADP)‐ribosylation is a post‐translational protein modification implicated in the regulation of a range of cellular processes. A family…”
Get full text

APE2 Zf-GRF facilitates 3′-5′ resection of DNA damage following oxidative stress by Wallace, Bret D., Berman, Zachary, Mueller, Geoffrey A., Lin, Yunfeng, Chang, Timothy, Andres, Sara N., Wojtaszek, Jessica L., DeRose, Eugene F., Appel, C. Denise, London, Robert E., Yan, Shan, Williams, R. Scott

“…The Xenopus laevis APE2 (apurinic/apyrimidinic endonuclease 2) nuclease participates in 3′-5′ nucleolytic resection of oxidative DNA damage and activation of…”
Get full text

Molecular basis for processing of topoisomerase 1-triggered DNA damage by Apn2/APE2 by Williams, Jessica S., Wojtaszek, Jessica L., Appel, Denise C., Krahn, Juno, Wallace, Bret D., Walsh, Evan, Kunkel, Thomas A., Williams, R. Scott

“…Topoisomerase 1 (Top1) incises DNA containing ribonucleotides to generate complex DNA lesions that are resolved by APE2 (Apn2 in yeast). How Apn2 engages and…”
Get full text

Mechanism of repair of 5′-topoisomerase II–DNA adducts by mammalian tyrosyl-DNA phosphodiesterase 2 by Schellenberg, Matthew J, Appel, C Denise, Adhikari, Sanjay, Robertson, Patrick D, Ramsden, Dale A, Williams, R Scott

“…Tyrosyl-DNA phosphodiesterase 2 (Tdp2) processes DNA termini with a 5′-phosphotyrosyl–linked topoisomerase II adduct, such as those stabilized by…”
Get full text

Sen1 architecture: RNA-DNA hybrid resolution, autoregulation, and insights into SETX inactivation in AOA2 by Appel, C. Denise, Bermek, Oya, Dandey, Venkata P., Wood, Makayla, Viverette, Elizabeth, Williams, Jason G., Bouvette, Jonathan, Riccio, Amanda A., Krahn, Juno M., Borgnia, Mario J., Williams, R. Scott

“…The senataxin (SETX, Sen1 in yeasts) RNA-DNA hybrid resolving helicase regulates multiple nuclear transactions, including DNA replication, transcription, and…”
Get full text

Ubiquitin stimulated reversal of topoisomerase 2 DNA-protein crosslinks by TDP2 by Schellenberg, Matthew J, Appel, C Denise, Riccio, Amanda A, Butler, Logan R, Krahn, Juno M, Liebermann, Jenna A, Cortés-Ledesma, Felipe, Williams, R Scott

“…Abstract Tyrosyl-DNA phosphodiesterase 2 (TDP2) reverses Topoisomerase 2 DNA–protein crosslinks (TOP2-DPCs) in a direct-reversal pathway licensed by ZATTZNF451…”
Get full text

Tetrameric Ctp1 coordinates DNA binding and DNA bridging in DNA double-strand-break repair by Andres, Sara N, Appel, C Denise, Westmoreland, James W, Williams, Jessica S, Nguyen, Yvonne, Robertson, Patrick D, Resnick, Michael A, Williams, R Scott

“…Structural, biophysical and genetic analyses reveal that Schizosaccharomyces pombe Ctp1 forms a flexible tetramer with multivalent DNA-binding and bridging…”
Get full text

Structure of the sirtuin‐linked macrodomain SAV0325 from Staphylococcus aureus by Appel, C. Denise, Feld, Geoffrey K., Wallace, Bret D., Williams, R. Scott

“…Cells use the post‐translational modification ADP‐ribosylation to control a host of biological activities. In some pathogenic bacteria, an operon‐encoded…”
Get full text

Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2 by Schellenberg, Matthew J, Perera, Lalith, Strom, Christina N, Waters, Crystal A, Monian, Brinda, Appel, C Denise, Vilas, Caroline K, Williams, Jason G, Ramsden, Dale A, Williams, R Scott

“…Mammalian Tyrosyl-DNA phosphodiesterase 2 (Tdp2) reverses Topoisomerase 2 (Top2) DNA-protein crosslinks triggered by Top2 engagement of DNA damage or poisoning…”
Get full text

Endogenous DNA 3′ Blocks Are Vulnerabilities for BRCA1 and BRCA2 Deficiency and Are Reversed by the APE2 Nuclease by Álvarez-Quilón, Alejandro, Wojtaszek, Jessica L., Mathieu, Marie-Claude, Patel, Tejas, Appel, C. Denise, Hustedt, Nicole, Rossi, Silvia Emma, Wallace, Bret D., Setiaputra, Dheva, Adam, Salomé, Ohashi, Yota, Melo, Henrique, Cho, Tiffany, Gervais, Christian, Muñoz, Ivan M., Grazzini, Eric, Young, Jordan T.F., Rouse, John, Zinda, Michael, Williams, R. Scott, Durocher, Daniel

“…The APEX2 gene encodes APE2, a nuclease related to APE1, the apurinic/apyrimidinic endonuclease acting in base excision repair. Loss of APE2 is lethal in cells…”
Get full text

Structure of an aprataxin -DNA complex with insights into AOA1 neurodegenerative disease by Williams, R Scott, Tumbale, Percy, Appel, C Denise, Kraehenbuehl, Rolf, Robertson, Patrick D, Williams, Jessica S, Krahn, Joe, Ahel, Ivan

“…Deficiencies in aprataxin, which reverses 5′-adenylate DNA adducts, can lead to the neurodegenerative disorder AOA1. Mutagenesis analyses and the crystal…”
Get full text

Structural features of the guide:target RNA duplex required for archaeal box C/D sRNA-guided nucleotide 2'-O-methylation by Appel, C Denise, Maxwell, E Stuart

“…Archaeal box C/D sRNAs guide the 2'-O-methylation of target nucleotides using both terminal box C/D and internal C'/D' RNP complexes. In vitro assembly of a…”
Get full text

Expression, purification, and biochemical analysis of the RNA-DNA hybrid helicase Sen1/SETX from Chaetomium thermophilum by Appel, C Denise, Bermek, Oya, Williams, R Scott

“…Yeast Sen1 and its vertebrate ortholog Senataxin (also known as SETX) are RNA-DNA resolving helicases. Sen1 and SETX are implicated in multiple critical…”
Get more information

Structure of the sirtuin-linked macrodomain SAV0325 from Staphylococcus aureus: SauMacro/SAV0325 X-Ray Structure by Appel, C. Denise, Feld, Geoffrey K., Wallace, Bret D., Williams, R. Scott

Get full text

Tetrameric Ctp1 coordinates DNA binding and bridging in DNA double strand break repair by Andres, Sara N., Appel, C. Denise, Westmoreland, Jim, Williams, Jessica S., Nguyen, Yvonne, Robertson, Patrick D., Resnick, Michael A., Williams, R. Scott

“…Ctp1 ( aka CtIP or Sae2) collaborates with Mre11–Rad50–Nbs1 to initiate repair of DNA double strand breaks (DSBs), but its function(s) remain enigmatic. We…”
Get full text

Mechanism of 5′ Topoisomerase II DNA adduct repair by mammalian Tyrosyl DNA phosphodiesterase 2 (Tdp2) by Schellenberg, Matthew J., Appel, C. Denise, Adhikari, Sanjay, Robertson, Patrick D., Ramsden, Dale A., Williams, R. Scott

“…The Topoisomerase II (topo II) DNA incision and ligation cycle can be poisoned (e.g following treatment with cancer chemotherapeutics) to generate cytotoxic…”
Get full text