Search Results - "Denis, Jérôme Alexandre"

Extracellular Vesicles in Breast Cancer: From Biology and Function to Clinical Diagnosis and Therapeutic Management by Loric, Sylvain, Denis, Jérôme Alexandre, Desbene, Cédric, Sabbah, Michèle, Conti, Marc

“…Breast cancer (BC) is the first worldwide most frequent cancer in both sexes and the most commonly diagnosed in females. Although BC mortality has been…”
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Cerebrospinal fluid and blood biomarkers of status epilepticus by Hanin, Aurélie, Lambrecq, Virginie, Denis, Jérôme Alexandre, Imbert‐Bismut, Françoise, Rucheton, Benoît, Lamari, Foudil, Bonnefont‐Rousselot, Dominique, Demeret, Sophie, Navarro, Vincent

“…Status epilepticus is a condition resulting either from the failure of the mechanisms responsible for seizure termination or from the initiation of mechanisms…”
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Droplet digital PCR of circulating tumor cells from colorectal cancer patients can predict KRAS mutations before surgery by Denis, Jérôme Alexandre, Patroni, Alexia, Guillerm, Erell, Pépin, Dominique, Benali-Furet, Naoual, Wechsler, Janine, Manceau, Gilles, Bernard, Maguy, Coulet, Florence, Larsen, Annette K., Karoui, Mehdi, Lacorte, Jean-Marc

“…In colorectal cancer (CRC), KRAS mutations are a strong negative predictor for treatment with the EGFR-targeted antibodies cetuximab and panitumumab. Since it…”
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Circulating tumor DNA is detectable in canine histiocytic sarcoma, oral malignant melanoma, and multicentric lymphoma by Prouteau, Anaïs, Denis, Jérôme Alexandre, De Fornel, Pauline, Cadieu, Edouard, Derrien, Thomas, Kergal, Camille, Botherel, Nadine, Ulvé, Ronan, Rault, Mélanie, Bouzidi, Amira, François, Romain, Dorso, Laetitia, Lespagnol, Alexandra, Devauchelle, Patrick, Abadie, Jérôme, André, Catherine, Hédan, Benoît

“…Circulating tumor DNA (ctDNA) has become an attractive biomarker in human oncology, and its use may be informative in canine cancer. Thus, we used droplet…”
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The Role of BEAMing and Digital PCR for Multiplexed Analysis in Molecular Oncology in the Era of Next-Generation Sequencing by Denis, Jérôme Alexandre, Guillerm, Erell, Coulet, Florence, Larsen, Annette K., Lacorte, Jean-Marc

“…BEAMing polymerase chain reaction (PCR) and digital PCR (dPCR) are used for robust and accurate quantification of nucleic acids. These methods are particularly…”
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Neuron Specific Enolase, S100-beta protein and progranulin as diagnostic biomarkers of status epilepticus by Hanin, Aurélie, Denis, Jérôme Alexandre, Frazzini, Valerio, Cousyn, Louis, Imbert-Bismut, Françoise, Rucheton, Benoit, Bonnefont-Rousselot, Dominique, Marois, Clémence, Lambrecq, Virginie, Demeret, Sophie, Navarro, Vincent

“…Status epilepticus (SE) is a life-threatening prolonged epileptic seizure. A rapid diagnosis is fundamental to initiate antiepileptic treatment and to prevent…”
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Evolutionary dynamics of glucose-deprived cancer cells: insights from experimentally informed mathematical modelling by Almeida, Luis, Denis, Jérôme Alexandre, Ferrand, Nathalie, Lorenzi, Tommaso, Prunet, Antonin, Sabbah, Michéle, Villa, Chiara

“…Glucose is a primary energy source for cancer cells. Several lines of evidence support the idea that monocarboxylate transporters, such as MCT1, elicit…”
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Combining MYD88 L265P mutation detection and clonality determination on CSF cellular and cell‐free DNA improves diagnosis of primary CNS lymphoma by Bravetti, Clotilde, Degaud, Michaël, Armand, Marine, Sourdeau, Elise, Mokhtari, Karima, Maloum, Karim, Osman, Jennifer, Verrier, Patricia, Houillier, Caroline, Roos‐Weil, Damien, Soussain, Carole, Choquet, Sylvain, Hoang‐Xuan, Khe, Le Garff‐Tavernier, Magali, Denis, Jérôme Alexandre, Davi, Frédéric

“…Summary Diagnosis of primary central nervous system lymphoma (PCNSL) is challenging, and although brain biopsy remains the gold standard, cerebrospinal fluid…”
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Clinico-biological markers for the prognosis of status epilepticus in adults by Hanin, Aurélie, Demeret, Sophie, Lambrecq, Virginie, Rohaut, Benjamin, Marois, Clémence, Bouguerra, Meriem, Demoule, Alexandre, Beaudeux, Jean-Louis, Bittar, Randa, Denis, Jérôme Alexandre, Imbert-Bismut, Françoise, Lamari, Foudil, Rucheton, Benoit, Bonnefont-Rousselot, Dominique, Chavez, Mario, Navarro, Vincent

“…Prediction of mortality, functional outcome and recovery after status epilepticus (SE) is a challenge. Biological and clinical markers have been proposed to…”
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miR-203 modulates epithelial differentiation of human embryonic stem cells towards epidermal stratification by Nissan, Xavier, Denis, Jérôme Alexandre, Saidani, Manoubia, Lemaitre, Gilles, Peschanski, Marc, Baldeschi, Christine

“…The molecular mechanisms controlling the differentiation of human basal keratinocyte stem cells towards the epidermis are well characterized, whereas the…”
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Serum neuron‐specific enolase: a new tool for seizure risk monitoring after status epilepticus by Hanin, Aurélie, Demeret, Sophie, Denis, Jérôme Alexandre, Nguyen‐Michel, Vi‐Huong, Rohaut, Benjamin, Marois, Clémence, Imbert‐Bismut, Françoise, Bonnefont‐Rousselot, Dominique, Levy, Pierre, Navarro, Vincent, Lambrecq, Virginie

“…Background and purpose There is a need for accurate biomarkers to monitor electroencephalography (EEG) activity and assess seizure risk in patients with acute…”
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Recurrent genomic instability of chromosome 1q in neural derivatives of human embryonic stem cells by Varela, Christine, Denis, Jérôme Alexandre, Polentes, Jérôme, Feyeux, Maxime, Aubert, Sophie, Champon, Benoite, Piétu, Geneviève, Peschanski, Marc, Lefort, Nathalie

“…Human pluripotent stem cells offer a limitless source of cells for regenerative medicine. Neural derivatives of human embryonic stem cells (hESCs) are…”
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Moving towards a personalized oncology: The contribution of genomic techniques and artificial intelligence in the use of circulating tumor biomarkers by Perrier, Alexandre, Hainaut, Pierre, Guenoun, Alexandre, Nguyen, Dinh-Phong, Lamy, Pierre-Jean, Guerber, Fabrice, Troalen, Frédéric, Denis, Jérôme Alexandre, Boissan, Mathieu

“…Technological advances, in particular the development of high-throughput sequencing, have led to the emergence of a new generation of molecular biomarkers for…”
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Clinical use and evolution of circulating biomarkers in the era of personalized oncology: From protein markers to bioclinical scores by Perrier, Alexandre, Hainaut, Pierre, Lamy, Pierre-Jean, Guenoun, Alexandre, Nguyen, Dinh-Phong, Guerber, Fabrice, Troalen, Frédéric, Denis, Jérôme Alexandre, Boissan, Mathieu

“…In oncology, the identification of targets that correlate with a type of cancer has led to a profound change in the notion of "tumor markers". Technological…”
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mTOR-dependent proliferation defect in human ES-derived neural stem cells affected by myotonic dystrophy type 1 by Denis, Jérôme Alexandre, Gauthier, Morgane, Rachdi, Latif, Aubert, Sophie, Giraud-Triboult, Karine, Poydenot, Pauline, Benchoua, Alexandra, Champon, Benoite, Maury, Yves, Baldeschi, Christine, Scharfmann, Raphael, Piétu, Geneviève, Peschanski, Marc, Martinat, Cécile

“…Patients with myotonic dystrophy type 1 exhibit a diversity of symptoms that affect many different organs. Among these are cognitive dysfunctions, the origin…”
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Global transcriptional profiling of neural and mesenchymal progenitors derived from human embryonic stem cells reveals alternative developmental signaling pathways by Denis, Jérôme Alexandre, Rochon-Beaucourt, Christelle, Champon, Benoite, Pietu, Geneviève

“…Human embryonic stem cells can be differentiated along different lineages, providing the possibility of a precise analysis of genes profiles associated with…”
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Complete resection of ulcerating, infiltrative, voluminous differentiated thyroid carcinoma by Allard, Lucie, Denis, Jérôme Alexandre, Godiris Petit, Gaëlle, Deniziaut, Gabrielle, Ghander, Cécile, Mathy, Elise, Guillerm, Erell, Lussey-Lepoutre, Charlotte, Leenhardt, Laurence, Buffet, Camille

“…An 87-year-old woman was referred to our department for a 15 cm right-sided cervical tumor with bleeding and skin ulceration, developed on a 6 cm papillary…”
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A defective Krab-domain zinc-finger transcription factor contributes to altered myogenesis in myotonic dystrophy type 1 by Gauthier, Morgane, Marteyn, Antoine, Denis, Jérôme Alexandre, Cailleret, Michel, Giraud-Triboult, Karine, Aubert, Sophie, Lecuyer, Camille, Marie, Joelle, Furling, Denis, Vernet, Rémi, Yanguas, Clara, Baldeschi, Christine, Pietu, Geneviève, Peschanski, Marc, Martinat, Cécile

“…Myotonic dystrophy type 1 (DM1) is an RNA-mediated disorder caused by a non-coding CTG repeat expansion that, in particular, provokes functional alteration of…”
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Low-Coverage Whole Genome Sequencing of Cell-Free DNA From Immunosuppressed Cancer Patients Enables Tumor Fraction Determination and Reveals Relevant Copy Number Alterations by Bouzidi, Amira, Labreche, Karim, Baron, Marine, Veyri, Marianne, Denis, Jérôme Alexandre, Touat, Mehdi, Sanson, Marc, Davi, Frédéric, Guillerm, Erell, Jouannet, Stéphanie, Charlotte, Frédéric, Bielle, Franck, Choquet, Sylvain, Boëlle, Pierre-Yves, Cadranel, Jacques, Leblond, Véronique, Autran, Brigitte, Lacorte, Jean-Marc, Spano, Jean-Philippe, Coulet, Florence

“…Cell-free DNA (cfDNA) analysis is a minimally invasive method that can be used to detect genomic abnormalities by directly testing a blood sample. This method…”
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Pluripotent Stem Cell-Based Drug Screening Reveals Cardiac Glycosides as Modulators of Myotonic Dystrophy Type 1 by Maury, Yves, Poydenot, Pauline, Brinon, Benjamin, Lesueur, Lea, Gide, Jacqueline, Roquevière, Sylvain, Côme, Julien, Polvèche, Hélène, Auboeuf, Didier, Alexandre Denis, Jérome, Pietu, Geneviève, Furling, Denis, Lechuga, Marc, Baghdoyan, Sandrine, Peschanski, Marc, Martinat, Cécile

“…There is currently no treatment for myotonic dystrophy type 1 (DM1), the most frequent myopathy of genetic origin. This progressive neuromuscular disease is…”
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