Search Results - "Denis, C. V."

von Willebrand factor: the old, the new and the unknown by LENTING, P. J., CASARI, C., CHRISTOPHE, O. D., DENIS, C. V.

“…von Willebrand factor (VWF) is a protein best known from its critical role in hemostasis. Indeed, any dysfunction of VWF is associated with a severe bleeding…”
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Clearance of von Willebrand factor by Casari, C., Lenting, P. J., Wohner, N., Christophe, O. D., Denis, C. V.

“…Summary Quantitative deficiencies in von Willebrand factor (VWF) are associated with abnormal hemostasis that can manifest in bleeding or thrombotic…”
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von Willebrand factor and inflammation by Kawecki, C., Lenting, P. J., Denis, C. V.

“…Summary Von Willebrand factor (VWF) is a plasma glycoprotein best known for its crucial hemostatic role in serving as a molecular bridge linking platelets to…”
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Use of a thrombopoietin receptor agonist in von Willebrand disease type 2B (p.V1316M) with severe thrombocytopenia and intracranial hemorrhage by Espitia, O., Ternisien, C., Agard, C., Boisseau, P., Denis, C. V., Fouassier, M.

“…We present here a 63-year old woman with a long history of immune thrombocytopenia. She was hospitalized for a traumatic intracranial hemorrhage with…”
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Increased metastatic potential of tumor cells in von Willebrand factor‐deficient mice by TERRAUBE, V., PENDU, R., BARUCH, D., GEBBINK, M. F. B. G., MEYER, D., LENTING, P. J., DENIS, C. V.

“…Background: The key role played by von Willebrand factor (VWF) in platelet adhesion suggests a potential implication in various pathologies, where this process…”
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Cysteine‐mutations in von Willebrand factor associated with increased clearance by SCHOOTEN, C. J., TJERNBERG, P., WESTEIN, E., TERRAUBE, V., CASTAMAN, G., MOURIK, J. A., HOLLESTELLE, M. J., VOS, H. L., BERTINA, R. M., BERG, H. M., EIKENBOOM, J. C. J., LENTING, P. J., DENIS, C. V.

“…Background: von Willebrand disease (VWD) is a bleeding disorder caused by the decrease of functional von Willebrand factor (VWF). Low levels of VWF can result…”
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Shear stress‐independent binding of von Willebrand factor‐type 2B mutants p.R1306Q & p.V1316M to LRP1 explains their increased clearance by Wohner, N., Legendre, P., Casari, C., Christophe, O. D., Lenting, P. J., Denis, C. V.

“…Summary Background von Willebrand factor (VWF) is cleared in a shear stress‐ and macrophage‐dependent manner by LRP1. von Willebrand disease (VWD)‐type 2B…”
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Insights from von Willebrand disease animal models by Denis, C V, Wagner, D D

“…von Willebrand disease is a genetic bleeding disorder that arises from abnormalities in von Willebrand factor, an adhesive glycoprotein involved in both…”
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Clearance mechanisms of von Willebrand factor and factor VIII by LENTING, P. J., VAN SCHOOTEN, C. J. M., DENIS, C. V.

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Factor VIII and von Willebrand factor are ligands for the carbohydrate-receptor Siglec-5 by Pegon, Julie N, Kurdi, Mohamad, Casari, Caterina, Odouard, Soline, Denis, Cécile V, Christophe, Olivier D, Lenting, Peter J

“…Factor VIII (FVIII) and von Willebrand factor (VWF) circulate in plasma in a tight non-covalent complex, being critical to hemostasis. Although structurally…”
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Arterial thrombosis: relevance of a model with two levels of severity assessed by histologic, ultrastructural and functional characterization by HECHLER, B., NONNE, C., ECKLY, A., MAGNENAT, S., RINCKEL, J.‐Y., DENIS, C. V., FREUND, M., CAZENAVE, J.‐P., LANZA, F., GACHET, C.

“…Background: We previously described a model of laser‐induced thrombosis in mesenteric arterioles with superficial and deep levels of injury producing a…”
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LDL receptor‐related protein 1 contributes to the clearance of the activated factor VII–antithrombin complex by Fazavana, J. G., Muczynski, V., Proulle, V., Wohner, N., Christophe, O. D., Lenting, P. J., Denis, C. V.

“…Summary Essentials Factor VIIa is cleared principally as a complex with antithrombin. Enzyme/serpin complexes are preferred ligands for the scavenger‐receptor…”
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Mouse models to study von Willebrand factor structure-function relationships in vivo by Denis, C V, Marx, I, Badirou, I, Pendu, R, Christophe, O

“…Von Willebrand factor (VWF) structure-function relationship has been studied only through in vitro approaches. The VWF-deficient mouse model has been extremely…”
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Assessment of endothelial damage and cardiac injury in a mouse model mimicking thrombotic thrombocytopenic purpura by Le Besnerais, M., Favre, J., Denis, C. V., Mulder, P., Martinet, J., Nicol, L., Levesque, H., Veyradier, A., Kopić, A., Motto, D. G., Coppo, P., Richard, V., Benhamou, Y.

“…Essentials Endothelial injury is thought to be a key event in thrombotic thrombocytopenic purpura (TTP). Endothelial and cardiac damages were assessed in a…”
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Factor VIII and von Willebrand factor - too sweet for their own good by LENTING, P. J., PEGON, J. N., CHRISTOPHE, O. D., DENIS, C. V.

“…Although factor VIII (FVIII) and von Willebrand factor (VWF) are products of two distinct genes, they circulate in plasma as a tight non‐covalent complex…”
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Identification and characterization of the elusive mutation causing the historical von Willebrand Disease type IIC Miami by Obser, T., Ledford‐Kraemer, M., Oyen, F., Brehm, M. A., Denis, C. V., Marschalek, R., Montgomery, R. R., Sadler, J. E., Schneppenheim, S., Budde, U., Schneppenheim, R.

“…Essentials Von Willebrand disease IIC Miami features high von Willebrand factor (VWF) with reduced function. We aimed to identify and characterize the elusive…”
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Characterization of the interaction between von Willebrand factor and osteoprotegerin by SHAHBAZI, S., LENTING, P. J., FRIBOURG, C., TERRAUBE, V., DENIS, C. V., CHRISTOPHE, O. D.

“…Background and objective: Osteoprotegerin (OPG), a member of the tumor necrosis‐factor receptor superfamily, plays an important role in bone remodeling and is…”
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von Willebrand factor clearance does not involve proteolysis by ADAMTS‐13 by BADIROU, I., KURDI, M., RAYES, J., LEGENDRE, P., CHRISTOPHE, O. D., LENTING, P. J., DENIS, C. V.

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Towards standardization of in vivo thrombosis studies in mice by DENIS, C. V., DUBOIS, C., BRASS, L. F., HEEMSKERK, J. W. M., LENTING, P. J.

“…To cite this article: Denis CV, Dubois C, Brass LF, Heemskerk JWM, Lenting PJ, Biorheology Subcommittee of the SSC of the ISTH. Towards standardization of in…”
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The Clearance Mechanism of Chilled Blood Platelets by Hoffmeister, Karin M., Felbinger, Thomas W., Falet, Hervé, Denis, Cécile V., Bergmeier, Wolfgang, Mayadas, Tanya N., von Andrian, Ulrich H., Wagner, Denisa D., Stossel, Thomas P., Hartwig, John H.

“…Platelet transfusion is a very common lifesaving medical procedure. Not widely known is the fact that platelets, unlike other blood cells, rapidly leave the…”
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