Search Results - "Dengler, Michael A."

Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection by Doerflinger, Marcel, Deng, Yexuan, Whitney, Paul, Salvamoser, Ranja, Engel, Sven, Kueh, Andrew J., Tai, Lin, Bachem, Annabell, Gressier, Elise, Geoghegan, Niall D., Wilcox, Stephen, Rogers, Kelly L., Garnham, Alexandra L., Dengler, Michael A., Bader, Stefanie M., Ebert, Gregor, Pearson, Jaclyn S., De Nardo, Dominic, Wang, Nancy, Yang, Chenying, Pereira, Milton, Bryant, Clare E., Strugnell, Richard A., Vince, James E., Pellegrini, Marc, Strasser, Andreas, Bedoui, Sammy, Herold, Marco J.

“…Programmed cell death contributes to host defense against pathogens. To investigate the relative importance of pyroptosis, necroptosis, and apoptosis during…”
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Clonal hematopoiesis, myeloid disorders and BAX-mutated myelopoiesis in patients receiving venetoclax for CLL by Blombery, Piers, Lew, Thomas E., Dengler, Michael A., Thompson, Ella R., Lin, Victor S., Chen, Xiangting, Nguyen, Tamia, Panigrahi, Ashish, Handunnetti, Sasanka M., Carney, Dennis A., Westerman, David A., Tam, Constantine S., Adams, Jerry M., Wei, Andrew H., Huang, David C.S., Seymour, John F., Roberts, Andrew W., Anderson, Mary Ann

“…The BCL2 inhibitor venetoclax has established therapeutic roles in chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML). As BCL2 is an important…”
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Imaging of myocardial infarction using ultrasmall superparamagnetic iron oxide nanoparticles: a human study using a multi-parametric cardiovascular magnetic resonance imaging approach by Yilmaz, Ali, Dengler, Michael A, van der Kuip, Heiko, Yildiz, Handan, Rösch, Sabine, Klumpp, Siegfried, Klingel, Karin, Kandolf, Reinhard, Helluy, Xavier, Hiller, Karl-Heinz, Jakob, Peter M, Sechtem, Udo

“…The purpose of this clinical trial was to investigate whether cardiovascular magnetic resonance imaging (CMR) using ferumoxytol (Feraheme™, FH), an ultrasmall…”
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p53 hypersensitivity is the predominant mechanism of the unique responsiveness of testicular germ cell tumor (TGCT) cells to cisplatin by Gutekunst, Matthias, Oren, Moshe, Weilbacher, Andrea, Dengler, Michael A, Markwardt, Christiane, Thomale, Jürgen, Aulitzky, Walter E, van der Kuip, Heiko

“…Consistent with the excellent clinical results in testicular germ cell tumors (TGCT), most cell lines derived from this cancer show an exquisite sensitivity to…”
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BAX Activation: Mutations Near Its Proposed Non-canonical BH3 Binding Site Reveal Allosteric Changes Controlling Mitochondrial Association by Dengler, Michael A., Robin, Adeline Y., Gibson, Leonie, Li, Mark X., Sandow, Jarrod J., Iyer, Sweta, Webb, Andrew I., Westphal, Dana, Dewson, Grant, Adams, Jerry M.

“…To elicit apoptosis, BAX metamorphoses from an inert cytosolic monomer into homo-oligomers that permeabilize the mitochondrial outer membrane (MOM). A…”
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BAK α6 permits activation by BH3-only proteins and homooligomerization via the canonical hydrophobic groove by Li, Mark Xiang, Tan, Iris K. L., Ma, Stephen B., Hockings, Colin, Kratina, Tobias, Dengler, Michael A., Alsop, Amber E., Kluck, Ruth M., Dewson, Grant

“…BAK and BAX are the essential effectors of apoptosis because without them a cell is resistant to most apoptotic stimuli. BAK and BAX undergo conformation…”
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Subtle Changes in the Levels of BCL-2 Proteins Cause Severe Craniofacial Abnormalities by Grabow, Stephanie, Kueh, Andrew J., Ke, Francine, Vanyai, Hannah K., Sheikh, Bilal N., Dengler, Michael A., Chiang, William, Eccles, Samantha, Smyth, Ian M., Jones, Lynelle K., de Sauvage, Frederic J., Scott, Mark, Whitehead, Lachlan, Voss, Anne K., Strasser, Andreas

“…Apoptotic cell death removes unwanted cells and is regulated by interactions between pro-survival and pro-apoptotic members of the BCL-2 protein family. The…”
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Cisplatin Hypersensitivity of Testicular Germ Cell Tumors Is Determined by High Constitutive Noxa Levels Mediated by Oct-4 by GUTEKUNST, Matthias, MUELLER, Thomas, WEILBACHER, Andrea, DENGLER, Michael A, BEDKE, Jens, KRUCK, Stephan, OREN, Moshe, AULITZKY, Walter E, VAN DER KUIP, Heiko

“…Testicular germ cell tumors (TGCT) are considered a paradigm of chemosensitive tumors. Embryonal carcinoma cells represent the pluripotent entity of TGCTs and…”
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An analysis of the role of follicular lymphoma-associated fibroblasts to promote tumor cell viability following drug-induced apoptosis by Staiger, Annette M., Duppel, Jasmin, Dengler, Michael A., van der Kuip, Heiko, Vöhringer, Matthias C., Aulitzky, Walter E., Rosenwald, Andreas, Ott, German, Horn, Heike

“…Treatment response of follicular lymphomas (FL) is highly variable. We, therefore, investigated the role of FL cancer-associated fibroblasts (CAFs) on tumor…”
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Oncogenic stress induced by acute hyper-activation of Bcr-Abl leads to cell death upon induction of excessive aerobic glycolysis by Dengler, Michael A, Staiger, Annette M, Gutekunst, Matthias, Hofmann, Ute, Doszczak, Malgorzata, Scheurich, Peter, Schwab, Matthias, Aulitzky, Walter E, van der Kuip, Heiko

“…In response to deregulated oncogene activation, mammalian cells activate disposal programs such as programmed cell death. To investigate the mechanisms behind…”
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Non-coding RNAs and ferroptosis: potential implications for cancer therapy by Balihodzic, Amar, Prinz, Felix, Dengler, Michael A., Calin, George A., Jost, Philipp J., Pichler, Martin

“…Ferroptosis is a recently defined form of regulated cell death, which is biochemically and morphologically distinct from traditional forms of programmed cell…”
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BAX mitochondrial integration is regulated allosterically by its α1−α2 loop by Dengler, Michael A., Gibson, Leonie, Adams, Jerry M.

“…The conformational changes converting BAX from an inert cytosolic monomer into the homo-oligomers that permeabilize the mitochondrial outer membrane (MOM) are…”
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Nanobody cocktails potently neutralize SARS-CoV-2 D614G N501Y variant and protect mice by Pymm, Phillip, Adair, Amy, Chan, Li-Jin, Cooney, James P., Mordant, Francesca L., Allison, Cody C., Lopez, Ester, Haycroft, Ebene R., O’Neill, Matthew T., Tan, Li Lynn, Dietrich, Melanie H., Drew, Damien, Doerflinger, Marcel, Dengler, Michael A., Scott, Nichollas E., Wheatley, Adam K., Gherardin, Nicholas A., Venugopal, Hariprasad, Cromer, Deborah, Davenport, Miles P., Pickering, Raelene, Godfrey, Dale I., Purcell, Damian F. J., Kent, Stephen J., Chung, Amy W., Subbarao, Kanta, Pellegrini, Marc, Glukhova, Alisa, Tham, Wai-Hong

“…Neutralizing antibodies are important for immunity against SARS-CoV-2 and as therapeutics for the prevention and treatment of COVID-19. Here, we identified…”
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Acquired mutations in BAX confer resistance to BH3-mimetic therapy in acute myeloid leukemia by Moujalled, Donia M., Brown, Fiona C., Chua, Chong Chyn, Dengler, Michael A., Pomilio, Giovanna, Anstee, Natasha S., Litalien, Veronique, Thompson, Ella, Morley, Thomas, MacRaild, Sarah, Tiong, Ing S., Morris, Rhiannon, Dun, Karen, Zordan, Adrian, Shah, Jaynish, Banquet, Sebastien, Halilovic, Ensar, Morris, Erick, Herold, Marco J., Lessene, Guillaume, Adams, Jerry M., Huang, David C. S., Roberts, Andrew W., Blombery, Piers, Wei, Andrew H.

“…•Acquired BAX mutations represent a novel mechanism of adaptive resistance to venetoclax-based therapy for patients with AML.•Defective BAX enhances resistance…”
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Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias by Thijssen, Rachel, Diepstraten, Sarah T., Moujalled, Donia, Chew, Edward, Flensburg, Christoffer, Shi, Melissa X., Dengler, Michael A., Litalien, Veronique, MacRaild, Sarah, Chen, Maoshan, Anstee, Natasha S., Reljić, Boris, Gabriel, Sarah S., Djajawi, Tirta M., Riffkin, Chris D., Aubrey, Brandon J., Chang, Catherine, Tai, Lin, Xu, Zhen, Morley, Thomas, Pomilio, Giovanna, Bruedigam, Claudia, Kallies, Axel, Stroud, David A., Bajel, Ashish, Kluck, Ruth M., Lane, Steven W., Schoumacher, Marie, Banquet, Sébastien, Majewski, Ian J., Strasser, Andreas, Roberts, Andrew W., Huang, David C.S., Brown, Fiona C., Kelly, Gemma L., Wei, Andrew H.

“…Selective targeting of BCL-2 with the BH3-mimetic venetoclax has been a transformative treatment for patients with various leukemias. TP-53 controls apoptosis…”
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The BCL-2 family member BOK promotes KRAS-driven lung cancer progression in a p53-dependent manner by Meinhardt, Anna-Lena, Munkhbaatar, Enkhtsetseg, Höckendorf, Ulrike, Dietzen, Michelle, Dechant, Marta, Anton, Martina, Jacob, Anne, Steiger, Katja, Weichert, Wilko, Brcic, Luka, McGranahan, Nicholas, Branca, Caterina, Kaufmann, Thomas, Dengler, Michael A., Jost, Philipp J.

“…A variety of cancer entities are driven by KRAS mutations, which remain difficult to target clinically. Survival pathways, such as resistance to cell death,…”
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Potent efficacy of MCL-1 inhibitor-based therapies in preclinical models of mantle cell lymphoma by Dengler, Michael A., Teh, Charis E., Thijssen, Rachel, Gangoda, Lahiru, Lan, Ping, Herold, Marco J., Gray, Daniel H., Kelly, Gemma L., Roberts, Andrew W., Adams, Jerry M.

“…Apoptosis-regulating BCL-2 family members, which can promote malignant transformation and resistance to therapy, have become prime therapeutic targets, as…”
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Robust autoactivation for apoptosis by BAK but not BAX highlights BAK as an important therapeutic target by Iyer, Sweta, Uren, Rachel T., Dengler, Michael A., Shi, Melissa X., Uno, Etsuko, Adams, Jerry M., Dewson, Grant, Kluck, Ruth M.

“…BAK and BAX, which drive commitment to apoptosis, are activated principally by certain BH3-only proteins that bind them and trigger major rearrangements. One…”
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Characterization of a novel human BFL-1-specific monoclonal antibody by Gangoda, Lahiru, Teh, Charis E., Dengler, Michael A., Best, Sarah A., Weeden, Clare E., Tai, Lin, Lee, Erinna F., Fairlie, Walter D., Sutherland, Kate D., Harrison, Leonard C., Gray, Daniel H., Strasser, Andreas, Herold, Marco J.

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The Flavonoid Brusatol Induces Apoptosis in Aggressive Lymphoma Cells and Exhibits Synergistic Effect with Venetoclax by Szmyra, Marta M., Haingartner, Sandra, Jantscher, Sonja, Pansy, Katrin, Uhl, Barbara, Greinix, Hildegard T., Neumeister, Peter, Bernhart, Eva, Beham-Schmid, Christine, Dengler, Michael A., Klösch, Burkhard, Deutsch, Alexander J.A.

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