Search Results - "Dengler, J."

Safety and efficacy of imatinib in CML over a period of 10 years: data from the randomized CML-study IV by Kalmanti, L, Saussele, S, Lauseker, M, Müller, M C, Dietz, C T, Heinrich, L, Hanfstein, B, Proetel, U, Fabarius, A, Krause, S W, Rinaldetti, S, Dengler, J, Falge, C, Oppliger-Leibundgut, E, Burchert, A, Neubauer, A, Kanz, L, Stegelmann, F, Pfreundschuh, M, Spiekermann, K, Scheid, C, Pfirrmann, M, Hochhaus, A, Hasford, J, Hehlmann, R

“…Tyrosine kinase inhibitors (TKI) have changed the natural course of chronic myeloid leukemia (CML). With the advent of second-generation TKI safety and…”
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Assessment of imatinib as first-line treatment of chronic myeloid leukemia: 10-year survival results of the randomized CML study IV and impact of non-CML determinants by Hehlmann, R, Lauseker, M, Saußele, S, Pfirrmann, M, Krause, S, Kolb, H J, Neubauer, A, Hossfeld, D K, Nerl, C, Gratwohl, A, Baerlocher, G M, Heim, D, Brümmendorf, T H, Fabarius, A, Haferlach, C, Schlegelberger, B, Müller, M C, Jeromin, S, Proetel, U, Kohlbrenner, K, Voskanyan, A, Rinaldetti, S, Seifarth, W, Spieß, B, Balleisen, L, Goebeler, M C, Hänel, M, Ho, A, Dengler, J, Falge, C, Kanz, L, Kremers, S, Burchert, A, Kneba, M, Stegelmann, F, Köhne, C A, Lindemann, H W, Waller, C F, Pfreundschuh, M, Spiekermann, K, Berdel, W E, Müller, L, Edinger, M, Mayer, J, Beelen, D W, Bentz, M, Link, H, Hertenstein, B, Fuchs, R, Wernli, M, Schlegel, F, Schlag, R, de Wit, M, Trümper, L, Hebart, H, Hahn, M, Thomalla, J, Scheid, C, Schafhausen, P, Verbeek, W, Eckart, M J, Gassmann, W, Pezzutto, A, Schenk, M, Brossart, P, Geer, T, Bildat, S, Schäfer, E, Hochhaus, A, Hasford, J

“…Chronic myeloid leukemia (CML)-study IV was designed to explore whether treatment with imatinib (IM) at 400 mg/day ( n =400) could be optimized by doubling the…”
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Inhibition of IL-17A Attenuates Atherosclerotic Lesion Development in ApoE-Deficient Mice by Erbel, Christian, Chen, Lili, Bea, Florian, Wangler, Susanne, Celik, Sultan, Lasitschka, Felix, Wang, Ying, Bockler, Dittmar, Katus, Hugo A, Dengler, Thomas J

“…The importance of an (auto)immune response in atherogenesis is becoming increasingly well understood. IL-17A-expressing T cells modulate immune cell…”
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Randomized comparison of prophylactic and minimal residual disease-triggered imatinib after allogeneic stem cell transplantation for BCR–ABL1-positive acute lymphoblastic leukemia by Pfeifer, H, Wassmann, B, Bethge, W, Dengler, J, Bornhäuser, M, Stadler, M, Beelen, D, Vucinic, V, Burmeister, T, Stelljes, M, Faul, C, Dreger, P, Kiani, A, Schäfer-Eckart, K, Schwerdtfeger, R, Lange, E, Kubuschok, B, Horst, H A, Gramatzki, M, Brück, P, Serve, H, Hoelzer, D, Gökbuget, N, Ottmann, O G

“…Minimal residual disease (MRD) after allogeneic stem cell transplantation (SCT) for Ph+ acute lymphoblastic leukemia (ALL) is predictive of relapse. Imatinib…”
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Expression of the CTLA-4 ligand CD86 on plasmacytoid dendritic cells (pDC) predicts risk of disease recurrence after treatment discontinuation in CML by Schütz, C, Inselmann, S, Sausslele, S, Dietz, C T, Müller, M C, Eigendorff, E, Brendel, C A, Metzelder, S K, Brümmendorf, T H, Waller, C, Dengler, J, Goebeler, M E, Herbst, R, Freunek, G, Hanzel, S, Illmer, T, Wang, Y, Lange, T, Finkernagel, F, Hehlmann, R, Huber, M, Neubauer, A, Hochhaus, A, Guilhot, J, Xavier Mahon, F, Pfirrmann, M, Burchert, A

“…It is unknown, why only a minority of chronic myeloid leukemia (CML) patients sustains treatment free remission (TFR) after discontinuation of tyrosine kinase…”
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IL-17A influences essential functions of the monocyte/macrophage lineage and is involved in advanced murine and human atherosclerosis by Erbel, Christian, Akhavanpoor, Mohammadreza, Okuyucu, Deniz, Wangler, Susanne, Dietz, Alex, Zhao, Li, Stellos, Konstantinos, Little, Kristina M, Lasitschka, Felix, Doesch, Andreas, Hakimi, Maani, Dengler, Thomas J, Giese, Thomas, Blessing, Erwin, Katus, Hugo A, Gleissner, Christian A

“…Atherosclerosis is a chronic inflammatory disease. Lesion progression is primarily mediated by cells of the monocyte/macrophage lineage. IL-17A is a…”
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Early molecular and cytogenetic response is predictive for long-term progression-free and overall survival in chronic myeloid leukemia (CML) by Hanfstein, B, Müller, M C, Hehlmann, R, Erben, P, Lauseker, M, Fabarius, A, Schnittger, S, Haferlach, C, Göhring, G, Proetel, U, Kolb, H-J, Krause, S W, Hofmann, W-K, Schubert, J, Einsele, H, Dengler, J, Hänel, M, Falge, C, Kanz, L, Neubauer, A, Kneba, M, Stegelmann, F, Pfreundschuh, M, Waller, C F, Branford, S, Hughes, T P, Spiekermann, K, Baerlocher, G M, Pfirrmann, M, Hasford, J, Saußele, S, Hochhaus, A

“…In the face of competing first-line treatment options for CML, early prediction of prognosis on imatinib is desirable to assure favorable survival or otherwise…”
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Confocal Ellipsoidal Reflector System for a Mechanically Scanned Active Terahertz Imager by Llombart, Nuria, Cooper, Ken B, Dengler, Robert J, Bryllert, Tomas, Siegel, Peter H

“…We present the design of a reflector system that can rapidly scan and refocus a terahertz beam for high-resolution standoff imaging applications. The proposed…”
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Velocity of early BCR-ABL transcript elimination as an optimized predictor of outcome in chronic myeloid leukemia (CML) patients in chronic phase on treatment with imatinib by Hanfstein, B, Shlyakhto, V, Lauseker, M, Hehlmann, R, Saussele, S, Dietz, C, Erben, P, Fabarius, A, Proetel, U, Schnittger, S, Krause, S W, Schubert, J, Einsele, H, Hänel, M, Dengler, J, Falge, C, Kanz, L, Neubauer, A, Kneba, M, Stegelmann, F, Pfreundschuh, M, Waller, C F, Spiekermann, K, Baerlocher, G M, Pfirrmann, M, Hasford, J, Hofmann, W-K, Hochhaus, A, Müller, M C

“…Early assessment of response at 3 months of tyrosine kinase inhibitor treatment has become an important tool to predict favorable outcome. We sought to…”
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A novel method to estimate the response of habitat types to nitrogen deposition by Wamelink, G.W.W., Goedhart, P.W., Roelofsen, H.D., Bobbink, R., Posch, M., van Dobben, H.F., Biurrun, I., Bonari, G., Dengler, J., Dítě, D., Garbolino, E., Jansen, J., Jašková, A.K., Lenoir, J., Peterka, T.

“…Increasing nitrogen depositions adversely affect European landscapes, including habitats within the Natura2000 network. Critical loads for nitrogen deposition…”
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Green tea halts progression of cardiac transthyretin amyloidosis: an observational report by Kristen, Arnt V., Lehrke, Stephanie, Buss, Sebastian, Mereles, Derliz, Steen, Henning, Ehlermann, Philipp, Hardt, Stefan, Giannitsis, Evangelos, Schreiner, Rupert, Haberkorn, Uwe, Schnabel, Philipp A., Linke, Reinhold P., Röcken, Christoph, Wanker, Erich E., Dengler, Thomas J., Altland, Klaus, Katus, Hugo A.

“…Background Treatment options in patients with amyloidotic transthyretin (ATTR) cardiomyopathy are limited. Epigallocatechin-3-gallate (EGCG), the most abundant…”
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A High-Resolution Imaging Radar at 580 GHz by Cooper, K.B., Dengler, R.J., Chattopadhyay, G., Schlecht, E., Gill, J., Skalare, A., Mehdi, I., Siegel, P.H.

“…We have developed a high-resolution imaging radar at 580 GHz. Coherent illumination in the 576-589 GHz range and phase-sensitive detection are implemented in…”
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Effect of land abandonment on the vegetation of upland semi-natural grasslands in the Western Balkan Mts., Bulgaria by Vassilev, K, Pedashenko, H, Nikolov, S. C, Apostolova, I, Dengler, J

“…The area of semi-natural grasslands in Bulgaria has decreased tremendously in the past century due to agricultural intensification or abandonment. As these…”
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Time-Delay Multiplexing of Two Beams in a Terahertz Imaging Radar by Llombart, Nuria, Cooper, K B, Dengler, R J, Bryllert, T, Chattopadhyay, G, Siegel, P H

“…We demonstrate a time-delay multiplexing technique that doubles the frame rate of a 660-690-GHz imaging radar with minimal additional instrument complexity…”
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Compact Duplexing for a 680-GHz Radar Using a Waveguide Orthomode Transducer by Leal-Sevillano, Carlos A., Cooper, Ken B., Decrossas, Emmanuel, Dengler, Robert J., Ruiz-Cruz, Jorge A., Montejo-Garai, Jose R., Chattopadhyay, Goutam, Rebollar, Jesus M.

“…A compact 680-GHz waveguide orthomode transducer (OMT) and circular horn combination has been designed, tested, and characterized in a radar transceiver's…”
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Advances in the conservation of dry grasslands: Introduction to contributions from the seventh European Dry Grassland Meeting by Janišová, M, Bartha, S, Kiehl, K, Dengler, J

“…Dry grasslands in Europe are mostly of zoo-anthropogenic origin, but nevertheless they are among the most diverse plant communities of the world at small…”
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Prophylactic implantation of cardioverter-defibrillator in patients with severe cardiac amyloidosis and high risk for sudden cardiac death by Kristen, Arnt V., MD, Dengler, Thomas J., MD, Hegenbart, Ute, MD, Schonland, Stefan O., MD, Goldschmidt, Hartmut, MD, Sack, Falk-Udo, MD, Voss, Frederik, MD, Becker, Rüdiger, MD, Katus, Hugo A., MD, Bauer, Alexander, MD

“…Background Cardiac light-chain amyloidosis carries a high risk for death predominantly from progressive cardiomyopathy or sudden death (SCD). Independent risk…”
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Expression of the CTLA-4 ligand CD86 on plasmacytoid dendritic cells (pDC) predicts risk of disease recurrence after treatment discontinuation in CML by Schütz, C, Inselmann, S, Saussele, S, Dietz, C T, Müller, M C, Eigendorff, E, Brendel, C A, Metzelder, S K, Brümmendorf, T H, Waller, C, Dengler, J, Goebeler, M E, Herbst, R, Freunek, G, Hanzel, S, Illmer, T, Wang, Y, Lange, T, Finkernagel, F, Hehlmann, R, Huber, M, Neubauer, A, Hochhaus, A, Guilhot, J, Mahon, F X, Pfirrmann, M, Burchert, A

“…This corrects the article DOI: 10.1038/leu.2017.9…”
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Non-invasive predictors of survival in cardiac amyloidosis by Kristen, Arnt V., Perz, Jolanta B., Schonland, Stefan O., Hegenbart, Ute, Schnabel, Philipp A., Kristen, Joern H., Goldschmidt, Hartmut, Katus, Hugo A., Dengler, Thomas J.

“…Background: Patients with cardiac amyloidosis (CA) have increased mortality. Aims: Clinical, electrocardiographic, and echocardiographic parameters were…”
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Direct actions of angiopoietin-1 on human endothelium: evidence for network stabilization, cell survival, and interaction with other angiogenic growth factors by Papapetropoulos, A, García-Cardeña, G, Dengler, T J, Maisonpierre, P C, Yancopoulos, G D, Sessa, W C

“…Angiopoietin-1 (Ang-1) is a recently described angiogenic protein that activates the endothelial Tie 2 receptor. Disruption of the Ang-1 gene shows that it has…”
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