Search Results - "Denger, Stefanie"

Multiple mechanisms induce transcriptional silencing of a subset of genes, including oestrogen receptor α, in response to deacetylase inhibition by valproic acid and trichostatin A by REID, George, METIVIER, Raphaël, LIN, Chin-Yo, DENGER, Stefanie, IBBERSON, David, IVACEVIC, Tomi, BRAND, Heike, BENES, Vladimir, LIU, Edison T, GANNON, Frank

“…Valproate (VPA) and trichostatin A (TSA), inhibitors of zinc-dependent deacetylase activity, induce reduction in the levels of mRNA encoding oestrogen…”
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Expression of the estrogen receptor during differentiation of human osteoclasts by Denger, Stefanie, Reid, George, Gannon, Frank

“…Estrogens play a key role in bone structural integrity, which is maintained by the opposing activity of bone forming osteoblasts and bone resorbing…”
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Modulation of human estrogen receptor α F promoter by a protein kinase C/c-Src-dependent mechanism in osteoblast-like cells by Longo, Maurizio, Peruzzi, Barbara, Fortunati, Dario, De Luca, Veronica, Denger, Stefanie, Caselli, Gianfranco, Migliaccio, Silvia, Teti, Anna

“…The human estrogen receptor α (ERα ) gene is driven by multiple promoters, of which the F promoter alone is found to be active in primary osteoblasts. The…”
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Preclinical study on gene therapy of cervical carcinoma using adeno-associated virus vectors by Kunke, D, Grimm, D, Denger, S, Kreuzer, J, Delius, H, Komitowski, D, Kleinschmidt, J A

“…Approximately 90% of cervical carcinomas are causally linked to infections with high-risk human papillomaviruses (HPVs), whose oncogenicity has been assigned…”
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Cyclic, Proteasome-Mediated Turnover of Unliganded and Liganded ERα on Responsive Promoters Is an Integral Feature of Estrogen Signaling by Reid, George, Hübner, Michael R., Métivier, Raphaël, Brand, Heike, Denger, Stefanie, Manu, Dominique, Beaudouin, Joël, Ellenberg, Jan, Gannon, Frank

“…We present an integrated model of hERα-mediated transcription where both unliganded and liganded receptors cycle on estrogen-responsive promoters. Using ChIP,…”
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LDL Stimulates Chemotaxis of Human Monocytes Through a Cyclooxygenase-Dependent Pathway by Kreuzer, Jorg, Denger, Stefanie, Jahn, Lothar, Bader, Jorg, Ritter, Kai, von Hodenberg, Eberhard, Kubler, Wolfgang

“…Monocyte migration into the vessel wall is an early step in atherogenesis. Even though a number of chemotactic factors have been identified, the regulation of…”
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Identification of a new isoform of the human estrogen receptor-alpha (hER-α) that is encoded by distinct transcripts and that is able to repress hER-α activation function 1 by Flouriot, Gilles, Brand, Heike, Denger, Stefanie, Metivier, Raphaël, Kos, Martin, Reid, George, Sonntag-Buck, Vera, Gannon, Frank

“…A new isoform of the human estrogen receptor‐alpha (hER‐α) has been identified and characterized. This 46 kDa isoform (hERα46) lacks the N‐terminal 173 amino…”
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E2-mediated cathepsin D (CTSD) activation involves looping of distal enhancer elements by Bretschneider, Nancy, Sara Kangaspeska, Seifert, Martin, Reid, George, Gannon, Frank, Denger, Stefanie

“…Estrogen receptor alpha (ERα) is a ligand dependent transcription factor that regulates the expression of target genes through interacting with cis-acting…”
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Upstream Open Reading Frames Regulate the Translation of the Multiple mRNA Variants of the Estrogen Receptor α by Koš, Martin, Denger, Stefanie, Reid, George, Gannon, Frank

“…It is by now well established that the estrogen receptor α (ERα) is transcribed from multiple promoters. One direct consequence of multiple promoters is the…”
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Transcriptional complexes engaged by apo-estrogen receptor-α isoforms have divergent outcomes by Métivier, Raphaël, Penot, Graziella, Carmouche, Richard P, Hübner, Michael R, Reid, George, Denger, Stefanie, Manu, Dominique, Brand, Heike, Koš, Martin, Benes, Vladimir, Gannon, Frank

“…Unliganded (apo‐) estrogen receptor α (ERα, NR3A1) is classically considered as transcriptionally unproductive. Reassessing this paradigm demonstrated that…”
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A Dynamic Structural Model for Estrogen Receptor-α Activation by Ligands, Emphasizing the Role of Interactions between Distant A and E Domains by Métivier, Raphaël, Stark, Alexander, Flouriot, Gilles, Hübner, Michael R, Brand, Heike, Penot, Graziella, Manu, Dominique, Denger, Stefanie, Reid, George, Koš, Martin, Russell, Robert B, Kah, Olivier, Pakdel, Farzad, Gannon, Frank

“…The functional interplay between different domains of estrogen receptor-α (ERα, NR3A1) is responsible for the overall properties of the full-length protein. We…”
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Estrogen Induces Repression of the Breast Cancer and Salivary Gland Expression Gene in an Estrogen Receptor α-Dependent Manner by BRETSCHNEIDER, Nancy, BRAND, Heike, MILLER, Nicola, LOWERY, Aoife J, KERIN, Michael J, GANNON, Frank, DENGER, Stefanie

“…The focus of this study is on the expression and regulation of the estrogen-regulated breast cancer and salivary gland expression (BASE) gene that may function…”
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Transcriptome Profiling of Estrogen-Regulated Genes in Human Primary Osteoblasts Reveals an Osteoblast-Specific Regulation of the Insulin-Like Growth Factor Binding Protein 4 Gene by Denger, Stefanie, Bähr-Ivacevic, Tomi, Brand, Heike, Reid, George, Blake, Jonathon, Seifert, Martin, Lin, Chin-Yo, May, Klaus, Benes, Vladimir, Liu, Edison T, Gannon, Frank

“…Estradiol (E2) is believed to modulate physiological functions relevant to osteoblast biology through the actions of estrogen receptors (ERs) that in turn…”
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Thanatop : A novel 5-nitrofuran that is a highly active, cell-permeable inhibitor of topoisomerase II by POLYCARPOU-SCHWARZ, Maria, MÜLLER, Kerstin, DENGER, Stefanie, RIDDELL, Andrew, LEWIS, Joe, GANNON, Frank, REID, George

“…A series of nitrofuran-based compounds were identified as inhibitors of estrogen signaling in a cell-based, high-throughput screen of a diverse library of…”
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Tissue-specific expression of human ERα and ERβ in the male by Denger, Stefanie, Reid, George, Brand, Heike, Kos, Martin, Gannon, Frank

“…The important role of estrogens in women in physiological and pathological processes is well accepted, but recently it has become evident that estrogens are…”
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A Novel Promoter Is Involved in the Expression of Estrogen Receptor α in Human Testis and Epididymis by Brand, Heike, Kos, Martin, Denger, Stefanie, Flouriot, Gilles, Gromoll, Jörg, Gannon, Frank, Reid, George

“…The role of estrogens in the development and physiology of the male reproductive tract remains provocative, with a growing body of evidence suggesting that…”
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Upstream Open Reading Frames Regulate the Translation of the Multiple mRNA Variants of the Estrogen Receptor Î by Martin KoÅ, Stefanie Denger, George Reid, Frank Gannon

“…It is by now well established that the estrogen receptor α (ERα) is transcribed from multiple promoters. One direct consequence of multiple promoters is the…”
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Multiple mechanisms induce transcriptional silencing of a subset of genes, including oestrogen receptor , in response to deacetylase inhibition by valproic acid and trichostatin A by Reid, George, Métivier, Raphaël, Chin-Yo Lin, Denger, Stefanie, Ibberson, David, Ivacevic, Tomi, Brand, Heike, Benes, Vladimir, Liu, Edison T, Gannon, Frank

“…Valproate (VPA) and trichostatin A (TSA), inhibitors of zinc-dependent deacetylase activity, induce reduction in the levels of mRNA encoding oestrogen…”
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Minireview: Genomic Organization of the Human ERα Gene Promoter Region by Koš, Martin, Reid, George, Denger, Stefanie, Gannon, Frank

“…The ERα gene has been intensively studied for more than a decade. During this long time, multiple promoters used in ERα expression have been discovered in…”
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Transcriptional complexes engaged by apo-estrogen receptor-[alpha] isoforms have divergent outcomes by Métivier, Raphaël, Penot, Graziella, Carmouche, Richard P, Hübner, Michael R, Reid, George, Denger, Stefanie, Manu, Dominique, Brand, Heike, Kos, Martin, Benes, Vladimir, Gannon, Frank

“…Unliganded (apo-) estrogen receptor alpha (ERalpha, NR3A1) is classically considered as transcriptionally unproductive. Reassessing this paradigm demonstrated…”
Get full text