Search Results - "Deng, Yexuan"

Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection by Doerflinger, Marcel, Deng, Yexuan, Whitney, Paul, Salvamoser, Ranja, Engel, Sven, Kueh, Andrew J., Tai, Lin, Bachem, Annabell, Gressier, Elise, Geoghegan, Niall D., Wilcox, Stephen, Rogers, Kelly L., Garnham, Alexandra L., Dengler, Michael A., Bader, Stefanie M., Ebert, Gregor, Pearson, Jaclyn S., De Nardo, Dominic, Wang, Nancy, Yang, Chenying, Pereira, Milton, Bryant, Clare E., Strugnell, Richard A., Vince, James E., Pellegrini, Marc, Strasser, Andreas, Bedoui, Sammy, Herold, Marco J.

“…Programmed cell death contributes to host defense against pathogens. To investigate the relative importance of pyroptosis, necroptosis, and apoptosis during…”
Get full text

TCF3 is epigenetically silenced by EZH2 and DNMT3B and functions as a tumor suppressor in endometrial cancer by Gui, Tao, Liu, Ming, Yao, Bing, Jiang, Haiqin, Yang, Dongjun, Li, Qixiang, Zeng, Xiangwei, Wang, Ying, Cao, Jian, Deng, Yexuan, Li, Xinyu, Xu, Peipei, Zhou, Liqin, Li, Dake, Wang, Zhihui, Zen, Ke, Huang, David C. S., Chen, Bing, Wan, Guiping, Zhao, Quan

“…Endometrial cancer (EC) is the most common gynecological malignancy worldwide. However, the molecular mechanisms underlying EC progression are still largely…”
Get full text

PRMT1-mediated H4R3me2a recruits SMARCA4 to promote colorectal cancer progression by enhancing EGFR signaling by Yao, Bing, Gui, Tao, Zeng, Xiangwei, Deng, Yexuan, Wang, Zhi, Wang, Ying, Yang, Dongjun, Li, Qixiang, Xu, Peipei, Hu, Ruifeng, Li, Xinyu, Chen, Bing, Wang, Jin, Zen, Ke, Li, Haitao, Davis, Melissa J, Herold, Marco J, Pan, Hua-Feng, Jiang, Zhi-Wei, Huang, David C S, Liu, Ming, Ju, Junyi, Zhao, Quan

“…Aberrant changes in epigenetic mechanisms such as histone modifications play an important role in cancer progression. PRMT1 which triggers asymmetric…”
Get full text

NatD promotes lung cancer progression by preventing histone H4 serine phosphorylation to activate Slug expression by Ju, Junyi, Chen, Aiping, Deng, Yexuan, Liu, Ming, Wang, Ying, Wang, Yadong, Nie, Min, Wang, Chao, Ding, Hong, Yao, Bing, Gui, Tao, Li, Xinyu, Xu, Zhen, Ma, Chi, Song, Yong, Kvansakul, Marc, Zen, Ke, Zhang, Chen-Yu, Luo, Cheng, Fang, Ming, Huang, David C. S., Allis, C. David, Tan, Renxiang, Zeng, Changjiang Kathy, Wei, Jiwu, Zhao, Quan

“…N-α-acetyltransferase D (NatD) mediates N-α-terminal acetylation (Nt-acetylation) of histone H4 known to be involved in cell growth. Here we report that NatD…”
Get full text

Generation of a CRISPR activation mouse that enables modelling of aggressive lymphoma and interrogation of venetoclax resistance by Deng, Yexuan, Diepstraten, Sarah T., Potts, Margaret A., Giner, Göknur, Trezise, Stephanie, Ng, Ashley P., Healey, Gerry, Kane, Serena R., Cooray, Amali, Behrens, Kira, Heidersbach, Amy, Kueh, Andrew J., Pal, Martin, Wilcox, Stephen, Tai, Lin, Alexander, Warren S., Visvader, Jane E., Nutt, Stephen L., Strasser, Andreas, Haley, Benjamin, Zhao, Quan, Kelly, Gemma L., Herold, Marco J.

“…CRISPR technologies have advanced cancer modelling in mice, but CRISPR activation (CRISPRa) methods have not been exploited in this context. We establish a…”
Get full text

Engineered EGCG‐Containing Biomimetic Nanoassemblies as Effective Delivery Platform for Enhanced Cancer Therapy by Wu, Pengkai, Zhang, Haitian, Yin, Yin, Sun, Meiling, Mao, Shuai, Chen, Huihui, Deng, Yexuan, Chen, Shuai, Li, Shuo, Sun, Beicheng

“…Nano‐based immunotherapy of therapeutic biomolecules is attractive but tremendously hampered by the poor delivery efficiency. This study reports a novel…”
Get full text

Author Correction: Generation of a CRISPR activation mouse that enables modelling of aggressive lymphoma and interrogation of venetoclax resistance by Deng, Yexuan, Diepstraten, Sarah T., Potts, Margaret A., Giner, Göknur, Trezise, Stephanie, Ng, Ashley P., Healey, Gerry, Kane, Serena R., Cooray, Amali, Behrens, Kira, Heidersbach, Amy, Kueh, Andrew J., Pal, Martin, Wilcox, Stephen, Tai, Lin, Alexander, Warren S., Visvader, Jane E., Nutt, Stephen L., Strasser, Andreas, Haley, Benjamin, Zhao, Quan, Kelly, Gemma L., Herold, Marco J.

Get full text

Correction to: PRMT1-mediated H4R3me2a recruits SMARCA4 to promote colorectal cancer progression by enhancing EGFR signaling by Yao, Bing, Gui, Tao, Zeng, Xiangwei, Deng, Yexuan, Wang, Zhi, Wang, Ying, Yang, Dongjun, Li, Qixiang, Xu, Peipei, Hu, Ruifeng, Li, Xinyu, Chen, Bing, Wang, Jin, Zen, Ke, Li, Haitao, Davis, Melissa J, Herold, Marco J, Pan, Hua-Feng, Jiang, Zhi-Wei, Huang, David C. S, Liu, Ming, Ju, Junyi, Zhao, Quan

Get full text

Manipulating Offense and Defense Signaling to Fight Cold Tumors with Carrier‐Free Nanoassembly of Fluorinated Prodrug and siRNA by Wu, Pengkai, Zhang, Haitian, Sun, Meiling, Mao, Shuai, He, Qifeng, Shi, Yuze, Deng, Yexuan, Dong, Zhongjun, Xu, Qingxiang, Zhao, Chen, Zhang, Wenjie, Sun, Beicheng

“…Chemoimmunotherapy has shown great potential to activate an immune response, but the immunosuppressive microenvironment associated with T cell exhaustion…”
Get full text

AURKB promotes gastric cancer progression via activation of CCND1 expression by Nie, Min, Wang, Yadong, Yu, Zenong, Li, Xinyu, Deng, Yexuan, Wang, Ying, Yang, Dongjun, Li, Qixiang, Zeng, Xiangwei, Ju, Junyi, Liu, Ming, Zhao, Quan

“…Aurora kinase B (AURKB) triggers the phosphorylation of serine 10 on histone H3 (H3S10ph), which is important for chromosome condensation and cytokinesis…”
Get full text

Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway by Simpson, Daniel S., Pang, Jiyi, Weir, Ashley, Kong, Isabella Y., Fritsch, Melanie, Rashidi, Maryam, Cooney, James P., Davidson, Kathryn C., Speir, Mary, Djajawi, Tirta M., Hughes, Sebastian, Mackiewicz, Liana, Dayton, Merle, Anderton, Holly, Doerflinger, Marcel, Deng, Yexuan, Huang, Allan Shuai, Conos, Stephanie A., Tye, Hazel, Chow, Seong H., Rahman, Arfatur, Norton, Raymond S., Naderer, Thomas, Nicholson, Sandra E., Burgio, Gaetan, Man, Si Ming, Groom, Joanna R., Herold, Marco J., Hawkins, Edwin D., Lawlor, Kate E., Strasser, Andreas, Silke, John, Pellegrini, Marc, Kashkar, Hamid, Feltham, Rebecca, Vince, James E.

“…Cell death plays an important role during pathogen infections. Here, we report that interferon-γ (IFNγ) sensitizes macrophages to Toll-like receptor…”
Get full text

PRMT5-dependent transcriptional repression of c-Myc target genes promotes gastric cancer progression by Liu, Ming, Yao, Bing, Gui, Tao, Guo, Chan, Wu, Xiaobin, Li, Jiahuang, Ma, Lingling, Deng, Yexuan, Xu, Peipei, Wang, Ying, Yang, Dongjun, Li, Qixiang, Zeng, Xiangwei, Li, Xinyu, Hu, Ruifeng, Ge, Jingru, Yu, Zenong, Chen, Yugen, Chen, Bing, Ju, Junyi, Zhao, Quan

“…The proto-oncogene c-Myc regulates multiple biological processes mainly through selectively activating gene expression. However, the mechanisms underlying…”
Get full text

Abstract 3427: Finding critical cancer driving and cancer suppressing genes using functional genomics screening in vivo by Herold, Marco Josef, Mizutani, Shinsuke, Deng, Yexuan, Janic, Ana, Kueh, Andrew, Pal, Martin, Wilcox, Stephen, Tai, Lin, Kelly, Gemma L., Strasser, Andreas

“…Abstract P53 is one of the most potent tumour suppressors and its activity is also required for cancer cells to respond to diverse chemotherapeutic drugs…”
Get full text

Caspase‐8‐driven apoptotic and pyroptotic crosstalk causes cell death and IL‐1β release in X‐linked inhibitor of apoptosis (XIAP) deficiency by Hughes, Sebastian A, Lin, Meng, Weir, Ashley, Huang, Bing, Xiong, Liya, Chua, Ngee Kiat, Pang, Jiyi, Santavanond, Jascinta P, Tixeira, Rochelle, Doerflinger, Marcel, Deng, Yexuan, Yu, Chien‐Hsiung, Silke, Natasha, Conos, Stephanie A, Frank, Daniel, Simpson, Daniel S, Murphy, James M, Lawlor, Kate E, Pearson, Jaclyn S, Silke, John, Pellegrini, Marc, Herold, Marco J, Poon, Ivan K H, Masters, Seth L, Li, Mingsong, Tang, Qin, Zhang, Yuxia, Rashidi, Maryam, Geng, Lanlan, Vince, James E

“…Genetic lesions in X‐linked inhibitor of apoptosis (XIAP) pre‐dispose humans to cell death–associated inflammatory diseases, although the underlying mechanisms…”
Get full text

CARM1-mediated methylation of protein arginine methyltransferase 5 represses human γ-globin gene expression in erythroleukemia cells by Nie, Min, Wang, Yadong, Guo, Chan, Li, Xinyu, Wang, Ying, Deng, Yexuan, Yao, Bing, Gui, Tao, Ma, Chi, Liu, Ming, Wang, Panxue, Wang, Ruoyun, Tan, Renxiang, Fang, Ming, Chen, Bing, He, Yinghong, Huang, David C.S., Ju, Junyi, Zhao, Quan

“…Protein arginine methyltransferase 5 (PRMT5) is a member of the arginine methyltransferase protein family that critically mediates the symmetric dimethylation…”
Get full text

3155 – GENOME WIDE CRISPR/CAS9 KNOCKOUT SCREEN IN VIVO IDENTIFY GATOR1 COMPONENTS AS TUMOR SUPPRESSORS IN Eµ-MYC LYMPHOMAGENESIS by Potts, Maggie, Mizutani, Shinsuke, Deng, Yexuan, Giner, Göknur, Vaidyanathan, Srimayee, Ting, Keziah, Sridhar, Shruti, Diepstraten, Sarah, Kueh, Andrew, Pal, Martin, Healey, Geraldine, Tai, Lin, Kalooni, Deeksha, Whelan, Lauren, Pomilio, Giovanna, Liao, Yang, Wei, Andrew, Papenfuss, Tony, Wilcox, Stephen, Jeyasekharan, Anand, Shi, Wei, Kelly, Gemma, Brown, Kristin, Strasser, Andreas, Herold, Marco

Get full text

Heterochromatin Protein 1γ Is a Novel Epigenetic Repressor of Human Embryonic ϵ-Globin Gene Expression by Wang, Yadong, Wang, Ying, Ma, Lingling, Nie, Min, Ju, Junyi, Liu, Ming, Deng, Yexuan, Yao, Bing, Gui, Tao, Li, Xinyu, Guo, Chan, Ma, Chi, Tan, Renxiang, Zhao, Quan

“…Production of hemoglobin during development is tightly regulated. For example, expression from the human β-globin gene locus, comprising β-, δ-, ϵ-, and…”
Get full text

Heterochromatin Protein 1γ Is a Novel Epigenetic Repressor of Human Embryonic ɛ-Globin Gene Expression by Wang, Yadong, Wang, Ying, Ma, Lingling, Nie, Min, Ju, Junyi, Liu, Ming, Deng, Yexuan, Yao, Bing, Gui, Tao, Li, Xinyu, Guo, Chan, Ma, Chi, Tan, Renxiang, Zhao, Quan

“…Production of hemoglobin during development is tightly regulated. For example, expression from the human α-globin gene locus, comprising α-, δ-, ɛ-, and…”
Get full text

Suv4-20h1 promotes G1 to S phase transition by downregulating p21 WAF1/CIP1 expression in chronic myeloid leukemia K562 cells by Wu, Yupeng, Wang, Yadong, Liu, Ming, Nie, Min, Wang, Ying, Deng, Yexuan, Yao, Bing, Gui, Tao, Li, Xinyu, Ma, Lingling, Guo, Chan, Ma, Chi, Ju, Junyi, Zhao, Quan

“…Methylation of histone H4 lysine 20 (H4K20) has been associated with cancer. However, the functions of the histone methyltransferases that trigger histone…”
Get full text

Suv4-20h1 promotes G1 to S phase transition by downregulating [p21.sup.WAF1/CIP1] expression in chronic myeloid leukemia K562 cells by Wu, Yupeng, Wang, Yadong, Liu, Ming, Nie, Min, Wang, Ying, Deng, Yexuan, Yao, Bing, Gui, Tao, Li, Xinyu, Ma, Lingling, Guo, Chan, Ma, Chi, Ju, Junyi, Zhao, Quan

“…Methylation of histone H4 lysine 20 (H4K20) has been associated with cancer. However, the functions of the histone methyltransferases that trigger histone…”
Get full text