Search Results - "Deng, Xiexiong"
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1
An Energy-Independent Pro-longevity Function of Triacylglycerol in Yeast
Published in PLoS genetics (23-02-2016)“…Intracellular triacylglycerol (TAG) is a ubiquitous energy storage lipid also involved in lipid homeostasis and signaling. Comparatively, little is known about…”
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Journal Article -
2
Tripartite Chromatin Localization of Budding Yeast Shugoshin Involves Higher-Ordered Architecture of Mitotic Chromosomes
Published in G3 : genes - genomes - genetics (01-09-2018)“…The spindle assembly checkpoint (SAC) is key to faithful segregation of chromosomes. One requirement that satisfies SAC is appropriate tension between sister…”
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Journal Article -
3
Resolving acetylated and phosphorylated proteins by neutral urea Triton-polyacrylamide gel electrophoresis: NUT-PAGE
Published in BioTechniques (01-08-2014)“…Protein acetylation and phosphorylation are key modifications that regulate both normal and pathological protein functions. The gel systems currently used for…”
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Journal Article -
4
Identification of the structural proteins of VP1 and VP2 of a novel mud crab dicistrovirus
Published in Journal of virological methods (01-02-2011)“…Mud crab dicistrovirus (MCDV), a newly identified single-stranded positive RNA virus, is an important pathogen that causes serious economic losses to mud crab…”
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Journal Article -
5
Hyperphosphorylated tau aggregation and cytotoxicity modulators screen identified prescription drugs linked to Alzheimer's disease and cognitive functions
Published in Scientific reports (06-10-2020)“…The neurodegenerative Alzheimer’s disease (AD) affects more than 30 million people worldwide. There is thus far no cure or prevention for AD. Aggregation of…”
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Journal Article -
6
Identification of Tension Sensing Motif of Histone H3 in Saccharomyces cerevisiae and Its Regulation by Histone Modifying Enzymes
Published in Genetics (Austin) (01-11-2016)“…To ensure genome stability during cell division, all chromosomes must attach to spindles emanating from the opposite spindle pole bodies before segregation…”
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Journal Article -
7
Protein G-quadruplex interactions and their effects on phase transitions and protein aggregation
Published in Nucleic acids research (08-05-2024)“…The SERF family of proteins were originally discovered for their ability to accelerate amyloid formation. Znf706 is an uncharacterized protein whose N-terminus…”
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Journal Article -
8
Ribosomal quality control factors inhibit repeat-associated non-AUG translation from GC-rich repeats
Published in Nucleic acids research (27-02-2024)“…A GGGGCC (G4C2) hexanucleotide repeat expansion in C9ORF72 causes amyotrophic lateral sclerosis and frontotemporal dementia (C9ALS/FTD), while a CGG…”
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Journal Article -
9
A Failsafe for Sensing Chromatid Tension in Mitosis with the Histone H3 Tail in Saccharomyces cerevisiae
Published in Genetics (Austin) (01-02-2018)“…Mitotic fidelity is ensured by achieving biorientation on all paired chromosomes. The key signal for proper chromosome alignment is the tension between sister…”
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Journal Article -
10
Hyperphosphorylation Renders Tau Prone to Aggregate and to Cause Cell Death
Published in Molecular neurobiology (01-11-2020)“…Alzheimer’s disease (AD) is a neurodegenerative disorder without a cure or prevention to date. Hyperphosphorylated tau forms the neurofibrillary tangles (NFTs)…”
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Journal Article -
11
Yeast Tripartite Biosensors Sensitive to Protein Stability and Aggregation Propensity
Published in ACS chemical biology (17-04-2020)“…In contrast to the myriad approaches available to study protein misfolding and aggregation in vitro, relatively few tools are available for the study of these…”
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Journal Article -
12
Gaining Insights Into the Mitotic Tension Sensing Mechanism in Saccharomyces cerevisiae: Regulation of Chromatin Recruitment of Shugoshin Protein SGO1P
Published 01-01-2018“…Faithful segregation of chromosomes to progeny cells is essential for species perpetuation. Eukaryotic cells use the spindle assembly checkpoint (SAC) to…”
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Dissertation -
13
Protein Interaction Module–assisted Function X (PIMAX) Approach to Producing Challenging Proteins Including Hyperphosphorylated Tau and Active CDK5/p25 Kinase Complex
Published in Molecular & cellular proteomics (01-01-2015)“…Many biomedically critical proteins are underrepresented in proteomics and biochemical studies because of the difficulty of their production in Escherichia…”
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Journal Article -
14
An Energy-Independent Pro-longevity Function of Triacylglycerol in Yeast: e1005878
Published in PLoS genetics (01-02-2016)“…Intracellular triacylglycerol (TAG) is a ubiquitous energy storage lipid also involved in lipid homeostasis and signaling. Comparatively, little is known about…”
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Journal Article -
15
Structural insights into the classification of Mud Crab Reovirus
Published in Virus research (01-06-2012)“…Cryo-electron microscopy was applied to analyze mud crab reovirus (MCRV), which causes ‘sleeping disease’ in mud crab, Scylla serrata, a marine species…”
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Journal Article