Search Results - "Deng, Xianming"

Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders by Jiang, Hua, He, Hongbin, Chen, Yun, Huang, Wei, Cheng, Jinbo, Ye, Jin, Wang, Aoli, Tao, Jinhui, Wang, Chao, Liu, Qingsong, Jin, Tengchuan, Jiang, Wei, Deng, Xianming, Zhou, Rongbin

“…The NLRP3 inflammasome has been implicated in the pathogenesis of a wide variety of human diseases. A few compounds have been developed to inhibit NLRP3…”
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TLR4 signalling via Piezo1 engages and enhances the macrophage mediated host response during bacterial infection by Geng, Jing, Shi, Yiran, Zhang, Jinjia, Yang, Bingying, Wang, Ping, Yuan, Weihong, Zhao, Hao, Li, Junhong, Qin, Funiu, Hong, Lixin, Xie, Changchuan, Deng, Xianming, Sun, Yujie, Wu, Congying, Chen, Lanfen, Zhou, Dawang

“…TLR4 signaling plays key roles in the innate immune response to microbial infection. Innate immune cells encounter different mechanical cues in both health and…”
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RRx-001 ameliorates inflammatory diseases by acting as a potent covalent NLRP3 inhibitor by Chen, Yun, He, Hongbin, Lin, Bolong, Chen, Yun, Deng, Xianming, Jiang, Wei, Zhou, Rongbin

“…The NLRP3 inflammasome plays a crucial role in innate immune-mediated inflammation and contributes to the pathogenesis of multiple autoinflammatory, metabolic…”
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Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity by He, Hongbin, Jiang, Hua, Chen, Yun, Ye, Jin, Wang, Aoli, Wang, Chao, Liu, Qingsong, Liang, Gaolin, Deng, Xianming, Jiang, Wei, Zhou, Rongbin

“…Oridonin (Ori) is the major active ingredient of the traditional Chinese medicinal herb Rabdosia rubescens and has anti-inflammatory activity, but the target…”
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Deep high-temperature hydrothermal circulation in a detachment faulting system on the ultra-slow spreading ridge by Tao, Chunhui, Seyfried, W. E., Lowell, R. P., Liu, Yunlong, Liang, Jin, Guo, Zhikui, Ding, Kang, Zhang, Huatian, Liu, Jia, Qiu, Lei, Egorov, Igor, Liao, Shili, Zhao, Minghui, Zhou, Jianping, Deng, Xianming, Li, Huaiming, Wang, Hanchuang, Cai, Wei, Zhang, Guoyin, Zhou, Hongwei, Lin, Jian, Li, Wei

“…Coupled magmatic and tectonic activity plays an important role in high-temperature hydrothermal circulation at mid-ocean ridges. The circulation patterns for…”
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Tranilast directly targets NLRP3 to treat inflammasome‐driven diseases by Huang, Yi, Jiang, Hua, Chen, Yun, Wang, Xiaqiong, Yang, Yanqing, Tao, Jinhui, Deng, Xianming, Liang, Gaolin, Zhang, Huafeng, Jiang, Wei, Zhou, Rongbin

“…The dysregulation of NLRP3 inflammasome can cause uncontrolled inflammation and drive the development of a wide variety of human diseases, but the medications…”
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Low-dose metformin targets the lysosomal AMPK pathway through PEN2 by Ma, Teng, Tian, Xiao, Zhang, Baoding, Li, Mengqi, Wang, Yu, Yang, Chunyan, Wu, Jianfeng, Wei, Xiaoyan, Qu, Qi, Yu, Yaxin, Long, Shating, Feng, Jin-Wei, Li, Chun, Zhang, Cixiong, Xie, Changchuan, Wu, Yaying, Xu, Zheni, Chen, Junjie, Yu, Yong, Huang, Xi, He, Ying, Yao, Luming, Zhang, Lei, Zhu, Mingxia, Wang, Wen, Wang, Zhi-Chao, Zhang, Mingliang, Bao, Yuqian, Jia, Weiping, Lin, Shu-Yong, Ye, Zhiyun, Piao, Hai-Long, Deng, Xianming, Zhang, Chen-Song, Lin, Sheng-Cai

“…Metformin, the most prescribed antidiabetic medicine, has shown other benefits such as anti-ageing and anticancer effects 1 – 4 . For clinical doses of…”
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Modulation of brain cation-Cl− cotransport via the SPAK kinase inhibitor ZT-1a by Zhang, Jinwei, Bhuiyan, Mohammad Iqbal H., Zhang, Ting, Karimy, Jason K., Wu, Zhijuan, Fiesler, Victoria M., Zhang, Jingfang, Huang, Huachen, Hasan, Md Nabiul, Skrzypiec, Anna E., Mucha, Mariusz, Duran, Daniel, Huang, Wei, Pawlak, Robert, Foley, Lesley M., Hitchens, T. Kevin, Minnigh, Margaret B., Poloyac, Samuel M., Alper, Seth L., Molyneaux, Bradley J., Trevelyan, Andrew J., Kahle, Kristopher T., Sun, Dandan, Deng, Xianming

“…The SLC12A cation-Cl − cotransporters (CCC), including NKCC1 and the KCCs, are important determinants of brain ionic homeostasis. SPAK kinase ( STK39 ) is the…”
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Air curtain dust-collecting technology: Investigation of factors affecting dust control performance of air curtains in the developed transshipment system for soybean clearance based on numerical simulation by Xiaochuan, Li, Mingrui, Zhang, Yefeng, Jiang, Li, Wang, Xinli, Zhao, Xi, Chang, Haoyu, Bai, Xianming, Deng

“…Transshipment of compacted soybean is characterized by labor-intensive processes, long operating times, and a great amount of dust that cannot be collected by…”
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A Simplified PWM Strategy for a Neutral-Point-Clamped (NPC) Three-Level Converter With Unbalanced DC Links by Ye, Zongbin, Xu, Yiming, Wu, Xiang, Tan, Guojun, Deng, Xianming, Wang, Zhichuan

“…A simplified pulse width modulation (PWM) strategy for a neutral-point-clamped three-level converter with unbalanced dc links is proposed in this paper to…”
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Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration by Fan, Fuqin, He, Zhixiang, Kong, Lu-Lu, Chen, Qinghua, Yuan, Quan, Zhang, Shihao, Ye, Jinjin, Liu, Hao, Sun, Xiufeng, Geng, Jing, Yuan, Lunzhi, Hong, Lixin, Xiao, Chen, Zhang, Weiji, Sun, Xihuan, Li, Yunzhan, Wang, Ping, Huang, Lihong, Wu, Xinrui, Ji, Zhiliang, Wu, Qiao, Xia, Ning-Shao, Gray, Nathanael S, Chen, Lanfen, Yun, Cai-Hong, Deng, Xianming, Zhou, Dawang

“…Tissue repair and regenerative medicine address the important medical needs to replace damaged tissue with functional tissue. Most regenerative medicine…”
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Kirkendall effect-induced uniform stress distribution stabilizes nickel-rich layered oxide cathodes by Gao, Ziyao, Zhao, Chenglong, Zhou, Kai, Wu, Junru, Tian, Yao, Deng, Xianming, Zhang, Lihan, Lin, Kui, Kang, Feiyu, Peng, Lele, Wagemaker, Marnix, Li, Baohua

“…Nickel-rich layered oxide cathodes promise ultrahigh energy density but is plagued by the mechanical failure of the secondary particle upon (de)lithiation…”
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Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2 by Alessi, Dario R, Gray, Nathanael S, Deng, Xianming, Dzamko, Nicolas, Prescott, Alan, Davies, Paul, Liu, Qingsong, Yang, Qingkai, Lee, Jiing-Dwan, Patricelli, Matthew P, Nomanbhoy, Tyzoon K

“…Mutations in leucine-rich repeat kinase 2 (LRRK2) are strongly associated with late-onset autosomal dominant Parkinson's disease. We employed a new, parallel,…”
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Ezh2 regulates differentiation and function of natural killer cells through histone methyltransferase activity by Yin, Jie, Leavenworth, Jianmei W., Li, Yang, Luo, Qi, Xie, Huafeng, Liu, Xinhua, Huang, Shan, Yan, Han, Fu, Zheng, Zhang, Liyun Y., Zhang, Litao, Hao, Junwei, Wu, Xudong, Deng, Xianming, Roberts, Charles W. M., Orkin, Stuart H., Cantor, Harvey, Wang, Xi

“…Changes of histone modification status at critical lineage-specifying gene loci in multipotent precursors can influence cell fate commitment. The contribution…”
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ERK5 is activated by oncogenic BRAF and promotes melanoma growth by Tusa, Ignazia, Gagliardi, Sinforosa, Tubita, Alessandro, Pandolfi, Silvia, Urso, Carmelo, Borgognoni, Lorenzo, Wang, Jinhua, Deng, Xianming, Gray, Nathanael S, Stecca, Barbara, Rovida, Elisabetta

“…Malignant melanoma is among the most aggressive cancers and its incidence is increasing worldwide. Targeted therapies and immunotherapy have improved the…”
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Oxidizing fluids associated with detachment hosted hydrothermal systems: Example from the Suye hydrothermal field on the ultraslow-spreading Southwest Indian Ridge by Liao, Shili, Tao, Chunhui, Jamieson, John W., Liu, Jia, Zhu, Chuanwei, Barriga, Fernando J.A.S., Li, Wei, Liang, Jin, Yang, Weifang, Zhou, Jianping, Deng, Xianming, Yu, Junyu

“…The redox state of hydrothermal fluids on mid-ocean ridges, which is indirectly affected by the depth of hydrothermal circulation and crustal permeability,…”
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Proton storage chemistry in aqueous zinc‐organic batteries: A review by Deng, Xianming, Sarpong, James Kumankuma, Zhang, Guobin, Hao, Jing, Zhao, Xu, Li, Linyuan, Li, Hongfei, Han, Cuiping, Li, Baohua

“…Benefiting from the advantageous features of structural diversity and resource renewability, organic electroactive compounds are considered as attractive…”
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Sediment geochemistry reveals abundant off-axis hydrothermal fields on the ultraslow-spreading Southwest Indian Ridge by Liao, Shili, Tao, Chunhui, Dias, Ágata Alveirinho, Liu, Jia, Su, Xin, Lv, Shihui, Jamieson, John W., Zhou, Jianping, Deng, Xianming, Liang, Jin, Yang, Weifang, Li, Wei, Yang, Xianhui

“…•We identified up to 14 potential off-axis fields by anomaly threshold average + SD.•Two fields were validated after this systematic sediment geochemistry…”
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Evidence of a distal axis inactive high-temperature hydrothermal field on the ultraslow spreading Southwest Indian Ridge: Insights from mineralogy and geochemistry studies by Liao, Shili, Tao, Chunhui, Dias, Ágata Alveirinho, Deng, Xianming, Hu, Siyi, Liang, Jin, Yang, Weifang, Yang, Xianhui

“…The development of hydrothermal activities on mid-ocean ridges is primarily influenced by magmatic and tectonic activities close to the ridge axis. On slow and…”
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A Novel DC-Power Control Method for Cascaded H-Bridge Multilevel Inverter by Zongbin Ye, Linlin Jiang, Zhiguo Zhang, Dongsheng Yu, Zhichuan Wang, Xianming Deng, Fernando, Tyrone

“…The cascaded H-bridge converter has been widely used in industry. The ability of dealing with unequal power generation among dc links is necessarily required…”
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