Search Results - "Deng, Wenhai"

Essential Role of mTORC1 in Self-Renewal of Murine Alveolar Macrophages by Deng, Wenhai, Yang, Jialong, Lin, Xingguang, Shin, Jinwook, Gao, Jimin, Zhong, Xiao-Ping

“…Alveolar macrophages (AMϕ) have the capacity of local self-renewal through adult life; however, mechanisms that regulate AMϕ self-renewal remain poorly…”
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Preclinical evaluation of CD70-specific CAR T cells targeting acute myeloid leukemia by Wu, Gongqiang, Guo, Shanshan, Luo, Qian, Wang, Xiaoxia, Deng, Wenhai, Ouyang, Guifang, Pu, Jeffrey J, Lei, Wen, Qian, Wenbin

“…Chimeric antigen receptor (CAR)-T cell therapy has achieved unprecedented success in treating hematopoietic malignancies. However, this cell therapy is…”
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Periodontal disease increases the host susceptibility to COVID-19 and its severity: a Mendelian randomization study by Wang, Yi, Deng, Hui, Pan, Yihuai, Jin, Lijian, Hu, Rongdang, Lu, Yongyong, Deng, Wenhai, Sun, Weijian, Chen, Chengshui, Shen, Xian, Huang, Xiu-Feng

“…Emerging evidence shows that periodontal disease (PD) may increase the risk of Coronavirus disease 2019 (COVID-19) complications. Here, we undertook a…”
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Advances in clinical applications of kisspeptin-GnRH pathway in female reproduction by Hu, Kai-Lun, Chen, Zimiao, Li, Xiaoxue, Cai, Enci, Yang, Haiyan, Chen, Yi, Wang, Congying, Ju, Liping, Deng, Wenhai, Mu, Liangshan

“…Kisspeptin is the leading upstream regulator of pulsatile and surge Gonadotrophin-Releasing Hormone secretion (GnRH) in the hypothalamus, which acts as the key…”
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Proteome-wide analysis reveals potential therapeutic targets for Colorectal cancer: a two-sample mendelian randomization study by Cai, Yi-Xin, Wu, Yi-Qing, Liu, Jie, Pan, Huanle, Deng, Wenhai, Sun, Weijian, Xie, Congying, Huang, Xiu-Feng

“…Abstract Background Colorectal cancer (CRC) is a leading cause of cancer-related mortality, highlighting an unmet clinical need for more effective therapies…”
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Mechanistic target of rapamycin complex 1 is critical for invariant natural killer T-cell development and effector function by Shin, Jinwook, Wang, Shang, Deng, Wenhai, Wu, Jinhong, Gao, Jimin, Zhong, Xiao-Ping

“…The mechanisms that control invariant natural killer T (i NKT)-cell development and function are still poorly understood. The mechanistic or mammalian target…”
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Engineering metal-organic framework nanoparticles trigger pyroptosis to boost colon cancer immunotherapy by Wang, Xiang, Lu, Xufeng, Yang, Xinxin, Zhu, Bingzi, Deng, Wenhai, Ye, Qinfan, Bai, Binglong, Liang, Danna, Shao, Bingxuan, Huang, Yingpeng, You, Tao, Zhang, Weiteng, Sun, Weijian, Shen, Xian

“…[Display omitted] •A doxorubicin-loaded metal–organic framework nanoplatform (DOX@Zr-MOF) enabled high drug loading efficiency and excellent pH-responsive…”
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Circulating Mucosal-Associated Invariant T Cells in a Large Cohort of Healthy Chinese Individuals From Newborn to Elderly by Chen, Pengcheng, Deng, Wenhai, Li, Dandan, Zeng, Tai, Huang, Ling, Wang, Qun, Wang, Jinli, Zhang, Weiguang, Yu, Xiaoxiao, Duan, Deming, Wang, Jinle, Xia, Hong, Chen, Hanbin, Huang, Wesley, Li, Jingao, Zhang, Dahong, Zhong, Xiao-Ping, Gao, Jimin

“…Mucosal-associated invariant T (MAIT) cells, which are enriched in human blood and express a semi-invariant TCR chain, play important roles in conditions such…”
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Glutamine Metabolism Underlies the Functional Similarity of T Cells between Nile Tilapia and Tetrapod by Li, Kang, Wei, Xiumei, Jiao, Xinying, Deng, Wenhai, Li, Jiaqi, Liang, Wei, Zhang, Yu, Yang, Jialong

“…As the lowest organisms possessing T cells, fish are instrumental for understanding T cell evolution and immune defense in early vertebrates. This study…”
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Elesclomol Loaded Copper Oxide Nanoplatform Triggers Cuproptosis to Enhance Antitumor Immunotherapy by Lu, Xufeng, Chen, Xiaodong, Lin, Chengyin, Yi, Yongdong, Zhao, Shengsheng, Zhu, Bingzi, Deng, Wenhai, Wang, Xiang, Xie, Zuoliang, Rao, Shangrui, Ni, Zhonglin, You, Tao, Li, Liyi, Huang, Yingpeng, Xue, Xiangyang, Yu, Yaojun, Sun, Weijian, Shen, Xian

“…The induction of cuproptosis, a recently identified form of copper‐dependent immunogenic cell death, is a promising approach for antitumor therapy. However,…”
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CD70‐targeting CAR‐T cells have potential activity against CD19‐negative B‐cell Lymphoma by Deng, Wenhai, Chen, Panpan, Lei, Wen, Xu, Yang, Xu, Nengwen, Pu, Jeffrey J., Liang, Aibin, Qian, Wenbin

“…Abbreviations IFN Interferon NF-κB Nuclear factor kappa B NSG NOD/SCID/interleukin-2 receptor subunit γ−/− Th1 T helper cell type 1 TNF Tumor Necrosis Factor…”
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Tumor-derived exosomes induce initial activation by exosomal CD19 antigen but impair the function of CD19-specific CAR T-cells via TGF-β signaling by Hao, Yuanyuan, Chen, Panpan, Guo, Shanshan, Li, Mengyuan, Jin, Xueli, Zhang, Minghuan, Deng, Wenhai, Li, Ping, Lei, Wen, Liang, Aibin, Qian, Wenbin

“…Tumor-derived exosomes (TEXs) enriched in immune suppressive molecules predominantly drive T-cell dysfunction and impair antitumor immunity. Chimeric antigen…”
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PEGylated Elesclomol@Cu(Ⅱ)-based Metal‒organic framework with effective nanozyme performance and cuproptosis induction efficacy for enhanced PD-L1-based immunotherapy by Lu, Xufeng, Deng, Wenhai, Wang, Shuaibin, Zhao, Shengsheng, Zhu, Bingzi, Bai, Binglong, Mao, Yiwen, Lin, Ji, Yi, Yongdong, Xie, Zuoliang, Wang, Xiang, Lu, Yongyong, Huang, Xiufeng, You, Tao, Chen, Xiaolei, Sun, Weijian, Shen, Xian

“…Nanozymes constitute a promising treatment strategy for antitumor therapy. However, the catalytic function of metal‒organic framework (MOF)-based nanozymes…”
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ART and Serum albumin are influencing factors of the 5-year survival rate of people living with HIV undergoing maintenance hemodialysis caused by HIV: A cohort study by Su, Chunxiong, Ma, Yuting, Liang, Huiping, Huang, Aixian, Deng, Wenhai, Zhou, Jia, Liu, Huaying

“…Human immunodeficiency virus (HIV) infection is one of the most prominent public health problems worldwide. The 5-year survival rate of people living with HIV…”
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Diagnostic Value of Kisspeptin Levels on Early Pregnancy Outcome: a Systematic Review and Meta-analysis by Hu, Kai-Lun, Chen, Zimiao, Deng, Wenhai, Li, Xiaoxue, Ju, Liping, Yang, Haiyan, Zhang, Hong, Mu, Liangshan

“…The objective of this study is to investigate whether kisspeptin levels in early pregnancy have a better diagnostic value on early pregnancy outcome as…”
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Loss of LOXL2 Promotes Uterine Hypertrophy and Tumor Progression by Enhancing H3K36ac-Dependent Gene Expression by Lu, Xufeng, Xin, Dazhuan E, Du, Juanjuan K, Zou, Quanli C, Wu, Qian, Zhang, Yanan S, Deng, Wenhai, Yue, Jicheng, Fan, Xing S, Zeng, Yuanyuan, Cheng, Xiaju, Li, Xue, Hou, Zhaoyuan, Mohan, Man, Zhao, Ting C, Lu, Xiaomei, Chang, Zhijie, Xu, Liyan, Sun, Yu, Zu, Xiongbing, Zhang, Yu, Chinn, Y Eugene

“…Lysyl oxidase-like 2 (LOXL2) is a member of the scavenger receptor cysteine-rich (SRCR) repeat carrying LOX family. Although LOXL2 is suspected to be involved…”
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Phenanthrene, but not its isomer anthracene, effectively activates both human and mouse nuclear receptor constitutive androstane receptor (CAR) and induces hepatotoxicity in mice by Yang, Han, Shi, Zhe, Wang, Xiao-Xiao, Cheng, Rong, Lu, Min, Zhu, Jiayin, Deng, Wenhai, Zeng, Yuyao, Zhao, Li-Yang, Zhang, Shu-Yun

“…Polycyclic aromatic hydrocarbons (PAHs) are a class of pervasive global environmental pollutants and adversely affect human health. Among PAHs, phenanthrene…”
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Chrysene, a four-ring polycyclic aromatic hydrocarbon, induces hepatotoxicity in mice by activation of the aryl hydrocarbon receptor (AhR) by Tao, Li-Ping, Li, Xue, Zhao, Ming-Zhu, Shi, Jing-Ru, Ji, Si-Qi, Jiang, Wen-Yuan, Liang, Qiu-Ju, Lei, Yu-Hang, Zhou, Yi-Yao, Cheng, Rong, Shi, Zhe, Deng, Wenhai, Zhu, Jiayin, Zhang, Shu-Yun

“…Polycyclic aromatic hydrocarbons (PAHs) are a group of persistent organic global environmental pollutants and cause harmful effects on human health. Here, we…”
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CD70-specific CAR NK cells expressing IL-15 for the treatment of CD19-negative B-cell malignancy by Guo, Shanshan, Lei, Wen, Jin, Xueli, Liu, Hui, Wang, James Q., Deng, Wenhai, Qian, Wenbin

“…•CD70-specific CAR NK cells secrete IL-15 and specifically lyse both CD19-positive and CD19-negative B-cell lymphoma in vitro and in vivo.•Two doses of CD70…”
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Graded diacylglycerol kinases α and ζ activities ensure mucosal-associated invariant T cell development by Pan, Yun, Deng, Wenhai, Xie, Jinhai, Zhang, Shimeng, Wan, Edwin C.K., Li, Lei, Tao, Huishan, Hu, Zhiming, Chen, Yongping, Ma, Li, Gao, Jimin, Zhong, Xiao-Ping

“…Mucosal-associated invariant T (MAIT) cells participate in both protective immunity and pathogenesis of diseases. Most murine MAIT cells express an invariant…”
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