Search Results - "Deng, Sarah K."

RPA antagonizes microhomology-mediated repair of DNA double-strand breaks by Deng, Sarah K, Gibb, Bryan, de Almeida, Mariana Justino, Greene, Eric C, Symington, Lorraine S

“…Resection of DNA double strand–break ends generates single strands that can spontaneously anneal to undergo mutagenic microhomology-mediated end joining…”
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Mre11-Sae2 and RPA Collaborate to Prevent Palindromic Gene Amplification by Deng, Sarah K., Yin, Yi, Petes, Thomas D., Symington, Lorraine S.

“…Foldback priming at DNA double-stranded breaks is one mechanism proposed to initiate palindromic gene amplification, a common feature of cancer cells. Here, we…”
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Replication protein A prevents promiscuous annealing between short sequence homologies: Implications for genome integrity by Deng, Sarah K, Chen, Huan, Symington, Lorraine S

“…Replication protein A (RPA) is the main eukaryotic single‐stranded DNA (ssDNA) binding protein, having essential roles in all DNA metabolic reactions involving…”
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Sae2 promotes DNA damage resistance by removing the Mre11–Rad50–Xrs2 complex from DNA and attenuating Rad53 signaling by Chen, Huan, Donnianni, Roberto A., Handa, Naofumi, Deng, Sarah K., Oh, Julyun, Timashev, Leonid A., Kowalczykowski, Stephen C., Symington, Lorraine S.

“…Significance Chromosomal double-strand breaks (DSBs) are cytotoxic forms of DNA damage that must be accurately repaired to maintain genome integrity. The…”
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The helicase domain of Polθ counteracts RPA to promote alt-NHEJ by Mateos-Gomez, Pedro A, Kent, Tatiana, Deng, Sarah K, McDevitt, Shane, Kashkina, Ekaterina, Hoang, Trung M, Pomerantz, Richard T, Sfeir, Agnel

“…Biochemical and cellular analyses reveal that the helicase activity of DNA polymerase theta (Polθ) antagonizes RPA to promote DNA strand annealing and…”
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The helicase domain of Pol[theta] counteracts RPA to promote alt-NHEJ by Mateos-Gomez, Pedro A, Kent, Tatiana, Deng, Sarah K, McDevitt, Shane, Kashkina, Ekaterina, Hoang, Trung M, Pomerantz, Richard T, Sfeir, Agnel

“…Mammalian polymerase theta (Pol[theta]) is a multifunctional enzyme that promotes error-prone DNA repair by alternative nonhomologous end joining (alt-NHEJ)…”
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