Search Results - "Deng, Ruishu"

Antibodies from donor B cells perpetuate cutaneous chronic graft-versus-host disease in mice by Jin, Hua, Ni, Xiong, Deng, Ruishu, Song, Qingxiao, Young, James, Cassady, Kaniel, Zhang, Mingfeng, Forman, Stephen, Martin, Paul J., Liu, Qifa, Zeng, Defu

“…Cutaneous sclerosis is one of the most common clinical manifestations of chronic graft-versus-host disease (cGVHD). Donor CD4+ T and B cells play important…”
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Extrafollicular CD4+ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease by Deng, Ruishu, Hurtz, Christian, Song, Qingxiao, Yue, Chanyu, Xiao, Gang, Yu, Hua, Wu, Xiwei, Muschen, Markus, Forman, Stephen, Martin, Paul J., Zeng, Defu

“…Chronic graft-versus-host disease (cGVHD) is an autoimmune-like syndrome mediated by pathogenic CD4 + T and B cells, but the function of extrafollicular and…”
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IgG gene expression and its possible significance in prostate cancers by Liu, Yuxuan, Chen, Zhengshan, Niu, Na, Chang, Qing, Deng, Ruishu, Korteweg, Christine, Gu, Jiang

“…BACKGROUND In spite of recent advances in treatment strategies, prostate cancer (PCa) remains the second leading cause of cancer death in men with its genetic…”
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PD-L1 interacts with CD80 to regulate graft-versus-leukemia activity of donor CD8+ T cells by Ni, Xiong, Song, Qingxiao, Cassady, Kaniel, Deng, Ruishu, Jin, Hua, Zhang, Mingfeng, Dong, Haidong, Forman, Stephen, Martin, Paul J, Chen, Yuan-Zhong, Wang, Jianmin, Zeng, Defu

“…Programmed death ligand-1 (PD-L1) interacts with programmed death-1 (PD-1) and the immunostimulatory molecule CD80 and functions as a checkpoint to regulate…”
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Thymic damage, impaired negative selection, and development of chronic graft-versus-host disease caused by donor CD4+ and CD8+ T cells by Wu, Tao, Young, James S, Johnston, Heather, Ni, Xiong, Deng, Ruishu, Racine, Jeremy, Wang, Miao, Wang, Audrey, Todorov, Ivan, Wang, Jianmin, Zeng, Defu

“…Prevention of chronic graft-versus-host disease (cGVHD) remains a major challenge in allogeneic hematopoietic cell transplantation (HCT) owing to limited…”
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B7H1/CD80 interaction augments PD-1-dependent T cell apoptosis and ameliorates graft-versus-host disease by Deng, Ruishu, Cassady, Kaniel, Li, Xiaofan, Yao, Sheng, Zhang, Mingfeng, Racine, Jeremy, Lin, Jeffrey, Chen, Lieping, Zeng, Defu

“…Interactions of B7H1 (programmed death ligand 1 [PD-L1]) with its two ligands, PD-1 and CD80, on T cells play a pivotal role in controlling T cell activation,…”
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A TRANSLATIONAL PHASE I STUDY OF TAUROURSODEOXYCHOLIC ACID (TUDCA) TO REDUCE SYMPTOMS AND ER STRESS IN ACTIVE ULCERATIVE COLITIS by Huang, Katherine, Deng, Ruishu, Liu, Ta-Chiang, Gremida, Anas, Deepak, Parakkal, Chen, Chien-Huan, Davidson, Nicholas, Kaufman, Randal, Ciorba, Matthew

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Ectopic clotting factor VIII expression and misfolding in hepatocytes as a cause for hepatocellular carcinoma by Kapelanski-Lamoureux, Audrey, Chen, Zhouji, Gao, Zu-Hua, Deng, Ruishu, Lazaris, Anthoula, Lebeaupin, Cynthia, Giles, Lisa, Malhotra, Jyoti, Yong, Jing, Zou, Chenhui, de Jong, Ype P., Metrakos, Peter, Herzog, Roland W., Kaufman, Randal J.

“…Hemophilia A gene therapy targets hepatocytes to express B domain deleted (BDD) clotting factor VIII (FVIII) to permit viral encapsidation. Since BDD is prone…”
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A TRANSLATIONAL PHASE I STUDY OF TAUROURSODEOXYCHOLIC ACID (TUDCA) TO REDUCE SYMPTOMS AND ER STRESS IN ACTIVE ULCERATIVE COLITIS by Huang, Katherine, Deng, Ruishu, Liu, Ta-Chiang, Gremida, Anas, Deepak, Parakkal, Chen, Chien-Huan, Davidson, Nicholas, Kaufman, Randal, Ciorba, Matthew

“…Abstract Background Emerging evidence has demonstrated that protein misfolding in the endoplasmic reticulum (ER), i.e., ER stress, plays fundamental roles in…”
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Circadian clock cryptochrome proteins regulate autoimmunity by Cao, Qi, Zhao, Xuan, Bai, Jingwen, Gery, Sigal, Sun, Haibo, Lin, De-Chen, Chen, Qi, Chen, Zhengshan, Mack, Lauren, Yang, Henry, Deng, Ruishu, Shi, Xianping, Chong, Ling-Wa, Cho, Han, Xie, Jianjun, Li, Quan-Zhen, Müschen, Markus, Atkins, Annette R., Liddle, Christopher, Yu, Ruth T., Alkan, Serhan, Said, Jonathan W., Zheng, Ye, Downes, Michael, Evans, Ronald M., Koeffler, H. Phillip

“…The circadian system regulates numerous physiological processes including immune responses. Here, we show that mice deficient of the circadian clock genes Cry1…”
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Su472 A TRANSLATIONAL PHASE I STUDY OF TAUROURSODEOXYCHOLIC ACID (TUDCA) TO REDUCE SYMPTOMS AND ER STRESS IN ACTIVE ULCERATIVE COLITIS by Huang, Katherine, Deng, Ruishu, Liu, Ta-Chiang, Wang, Miao, Gremida, Anas K., Deepak, Parakkal, Chen, Chien-Huan, Davidson, Nicholas O., Kaufman, Randal J., Ciorba, Matthew A.

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Tu1456: TAUROURSODEOXYCHOLIC ACID (TUDCA) REDUCES ER STRESS AND CLINICAL DISEASE ACTIVITY IN ULCERATIVE COLITIS: FINAL RESULTS OF A PHASE I TRIAL by Lamm, Vladimir, Deng, Ruishu, Huang, Katherine, Soleymanjahi, Saeed, Liu, Ta-Chiang, Xie, Yan, Gremida, Anas K., Deepak, Parakkal, Chen, Chien-Huan, Davidson, Nicholas O., Wang, Miao, Kaufman, Randal J., Ciorba, Matthew A.

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MHC-mismatched chimerism is required for induction of transplantation tolerance in autoimmune nonobese diabetic recipients by Wang, Miao, Racine, Jeremy, Zhang, Mingfeng, Wu, Tao, Deng, Ruishu, Johnston, Heather, Shen, Christine, Siswanto, Kathleen, Zeng, Defu

“…In nonautoimmune recipients, induction of mixed and complete chimerism with hematopoietic progenitor cells from MHC (HLA)-matched or -mismatched donors are…”
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Transient depletion of donor CD4+ T cells early after HCT allows recipient tissue PD-L1 to tolerize infiltrating CD8+ T cells and to prevent acute GVHD while preserving GVL effect by song, qingxiao, Ni, Xiong, Cassady, Kaniel, Deng, Ruishu, Jin, Hua, Zhang, Mingfeng, Forman, Stephen, Martin, Paul, Wang, Jianmin, Zeng, Defu

“…Abstract Prevention of graft-versus-host-disease (GVHD) while preserving graft-versus-leukemia/lymphoma (GVL) effect remains the Holy Grail for allogeneic…”
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PD-L1 interacts with CD80 to regulate graft-versusleukemia activity of donor [CD8.sup.+] T cells by Ni, Xiong, Song, Qingxiao, Cassady, Kaniel, Deng, Ruishu, Jin, Hua, Zhang, Mingfeng, Dong, Haidong, Forman, Stephen, Martin, Paul J, Chen, Yuan-Zhong, Wang, Jianmin, Zeng, Defu

“…Programmed death ligand-1 (PD-L1) interacts with programmed death-1 (PD-1) and the immunostimulatory molecule CD80 and functions as a checkpoint to regulate…”
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Antibodies from Donor B Cells Are Not Required for Initiating but Required for Persisting Scleroderma in Chronic Gvhd by Jin, Hua, Ni, Xiong, Deng, Ruishu, Young, James, Johnston, Heather F, Liu, Qifa, Zeng, Defu

“…We recently reported that in a chronic graft versus host disease (GVHD) model of DBA/2 donor to MHC-matched BALB/c recipient, donor CD4+ T and B cell…”
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Extrafollicular CD4+ T and B Interaction Induces Chronic Gvhd in the Absence of Germinal Center Formation by Deng, Ruishu, Hurtz, Christian, Yue, Chanyu, Xiao, Gang, Yu, Hua, Muschen, Markus, Forman, Stephen J., Martin, Paul J., Zeng, Defu

“…Chronic graft-versus-host disease (GVHD) in patients with allogeneic hematopoietic cell transplantation (HCT) is an immune-mediated syndrome. Both CD4+ T and B…”
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Fab fragment glycosylated IgG may play a central role in placental immune evasion by Gu, Jiang, Lei, Yu, Huang, Yuanping, Zhao, Yingying, Li, Jing, Huang, Tao, Zhang, Junjun, Wang, Juping, Deng, Xiaodong, Chen, Zhengshan, Korteweg, Christine, Deng, Ruishu, Yan, Meiling, Xu, Qian, Dong, Shengnan, Cai, Monghong, Luo, Lili, Huang, Guowei, Wang, Yun, Li, Qian, Lin, Changmei, Su, Meng, Yang, Chunzhang, Zhuang, Zhengping

“…STUDY QUESTION How does the placenta protect the fetus from immune rejection by the mother? SUMMARY ANSWER The placenta can produce IgG that is glycosylated at…”
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B7H1/B7.1 Interaction Alleviate Acute Gvhd in a PD-1 Dependent Manner by Deng, Ruishu, Cassady, Kaniel, Li, Xiaofan, Yao, Sheng, Zhang, Mingfeng, Racine, Jeremy, Lin, Jeffrey, Chen, Lieping, Zeng, Defu

“…Interactions of B7H1 (PD-L1) on antigen presenting cells with its two ligands, PD-1 and B7.1, on T cells play a pivotal role in controlling T cell activation,…”
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Host Tissue PD-L1 Separates GVL Effect from Gvhd after Temporary Depletion of Donor CD4+ T Cells Early after HCT by Ni, Xiong, Song, Qingxiao, Deng, Ruishu, Jin, Hua, Cassady, Kaniel M., Zhang, Mingfeng, Forman, Stephen J., Martin, Paul J., Wang, Jianmin, Zeng, Defu

“…Recipient tissue expression of programmed death-ligand 1 (PD-L1, B7H1) down-regulates graft-versus-host disease (GVHD) after allogeneic hematopoietic cell…”
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