Search Results - "Deng, James"

Characterization of pneumococcal serotype 7F in vaccine conjugation by Deng, James Z, Jia, Xiujuan, Zong, Chengli, He, Jian, Ha, Sha, Zhuang, Ping

“…Streptococcus pneumoniae is a highly invasive bacterial pathogen that can cause a range of illnesses. Pneumococcal capsular polysaccharides (CPS) are the main…”
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Multi-attribute characterization of pneumococcal conjugate vaccine by Size-exclusion chromatography coupled with UV-MALS-RI detections by Deng, James Z., Lancaster, Catherine, Winters, Michael A., Phillips, Katherine M., Zhuang, Ping, Ha, Sha

“…Streptococcus pneumoniae bacterial infection can cause serious diseases. Among more than 90 known streptococcus pneumoniae serotypes, more than 30 can cause…”
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Quantitation of Coxsackievirus A21 Viral Proteins in Mixtures of Empty and Full Capsids Using Capillary Western by Gillespie, Paul F, Rustandi, Richard R, Swartz, Andrew R, Shang, Liang, Raffaele, Jessica, Prout, Ashley, Cunningham, Nicholas, Dawod, Mohamed, Deng, James Z, Wang, Shiyi, Olson, Jessica, Shieh, Yvonne, Loughney, John W

“…A prototype strain of Coxsackievirus A21 (CVA21) is being evaluated as an oncolytic virus immunotherapy. CVA21 preferentially lyses cells that upregulate the…”
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Reverse-Phase Ultra-Performance Chromatography Method for Oncolytic Coxsackievirus Viral Protein Separation and Empty to Full Capsid Quantification by Deng, James Z, Rustandi, Richard R, Barbacci, Damon, Swartz, Andrew R, Gulasarian, Amanda, Loughney, John W

“…Oncolytic virus immunotherapy is emerging as a novel therapeutic approach for cancer treatment. Immunotherapy clinical drug candidate V937 is currently in…”
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Quantitation and characterization of serotype 6A activation for pneumococcal conjugate vaccine by cryo-EM and SEC methods by Lin, Mingxiang, Deng, James Z., Scapin, Giovanna, Yuan, Yue, Gomez-Llorente, Yacob, Tong, Weidong, Porambo, Richard, Kong, Jongrock, Ikemoto, Nori, Lancaster, Catherine, Kaelber, Jason, Winters, Michael, Zhuang, Ping

“…Pneumococcal conjugate vaccines (PCV) typically consist of capsular polysaccharides from different S. pneumoniae serotypes which are covalently attached to…”
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A new terahertz source from the wave particle duality mechanism by Deng, James T. Q.

“…The terahertz source (THz) is basically the electromagnetic wave radiation source generated by using the energy level transitions and photoelectric quantum…”
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Characterization of High Molecular Weight Pneumococcal Conjugate by SEC-MALS and AF4-MALS by Deng, James Z, Lin, Jason, Chen, Michelle, Lancaster, Catherine, Zhuang, Ping

“…Infections by Streptococcus pneumoniae can cause serious pneumococcal diseases and other medical complications among patients. Polysaccharide-based vaccines…”
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Antibody enhanced HPLC for serotype-specific quantitation of polysaccharides in pneumococcal conjugate vaccine by Deng, James Z., Kuster, Nathan, Drumheller, Ashley, Lin, Mingxiang, Ansbro, Frances, Grozdanovic, Milica, Samuel, Rachelle, Zhuang, Ping

“…Bacterial infection remains as one of the major healthcare issues, despite significant scientific and medical progress in this field. Infection by…”
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Copper-Facilitated Suzuki Reactions: Application to 2-Heterocyclic Boronates by Deng, James Z, Paone, Daniel V, Ginnetti, Anthony T, Kurihara, Hideki, Dreher, Spencer D, Weissman, Steven A, Stauffer, Shaun R, Burgey, Christopher S

“…The palladium-catalyzed Suzuki−Miyaura reaction has been utilized as one of the most powerful methods for C−C bond formation. However, Suzuki reactions of…”
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Effect of steam explosion treatment on characteristics of wheat straw by Han, Guangping, Deng, James, Zhang, Shuyin, Bicho, Paul, Wu, Qinglin

“…Steam explosion treatments were used to modify straw fiber attributes for panel manufacturing. In particular, the effect of steam temperature and retention…”
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Invention of novel 3-aminopiperidin-2-ones as calcitonin gene-related peptide receptor antagonists by Staas, Donnette D., Bell, Ian M., Burgey, Christopher S., Deng, James Z., Gallicchio, Steven N., Lim, John J., Paone, Daniel V., Potteiger, Craig M., Shaw, Anthony W., Stevenson, Heather, Stump, Craig A., Blair Zartman, C., Moore, Eric L., Bruno, Joseph G., Mosser, Scott D., White, Rebecca B., Kane, Stefanie A., Salvatore, Christopher A., Graham, Samuel L., Williams, Theresa M., Selnick, Harold G., Fraley, Mark E.

“…[Display omitted] •CGRP receptor antagonists have demonstrated antimigraine clinical efficacy.•Surprising SAR observations led to the invention of novel…”
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Identification and Quantification of a Pneumococcal Cell Wall Polysaccharide by Antibody-Enhanced Chromatography Assay by Deng, James Z, Chen, Zhifeng, Small, James, Yuan, Yue, Cox, Kara, Tang, Aimin, Roman, Jeanette, Guan, Liming, Feller, Katrina, Ansbro, Frances, Vora, Kalpit

“…Multivalent pneumococcal vaccines have been developed successfully to combat invasive pneumococcal diseases (IPD) and reduce the associated healthcare burden…”
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Protocol for the purification and transcriptomic analysis of mouse astrocytes using GFAT by Labarta-Bajo, Lara, Deng, James, Contreras, Minerva, Allen, Nicola J.

“…Astrocytes are glial cells of the central nervous system that modulate neuronal function. Here, we present glyoxal-fixed astrocyte nuclei transcriptomics…”
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SEC coupled with in-line multiple detectors for the characterization of an oncolytic Coxsackievirus by Deng, James Z., Rustandi, Richard R., Swartz, Andrew, Shieh, Yvonne, Baker, Jack B., Vlasak, Josef, Wang, Shiyi, Loughney, John W.

“…V937 is an oncolytic virus immunotherapy clinical drug candidate consisting of a proprietary formulation of Coxsackievirus A21 (CVA21). V937 specifically binds…”
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Dynamic Time Warping for Music Retrieval Using Time Series Modeling of Musical Emotions by Deng, James J., Leung, Clement H. C.

“…Musical signals have rich temporal information not only at the physical level but at the emotion level. The listeners may wish to find music excerpts that have…”
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Potent, Orally Bioavailable Calcitonin Gene-Related Peptide Receptor Antagonists for the Treatment of Migraine:  Discovery of N-[(3R,6S)-6-(2,3-Difluorophenyl)-2-oxo-1- (2,2,2-trifluoroethyl)azepan-3-yl]-4- (2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin- 1-yl)piperidine-1-carboxamide (MK-0974) by Paone, Daniel V, Shaw, Anthony W, Nguyen, Diem N, Burgey, Christopher S, Deng, James Z, Kane, Stefanie A, Koblan, Kenneth S, Salvatore, Christopher A, Mosser, Scott D, Johnston, Victor K, Wong, Bradley K, Miller-Stein, Cynthia M, Hershey, James C, Graham, Samuel L, Vacca, Joseph P, Williams, Theresa M

“…Calcitonin gene-related peptide (CGRP) has been implicated in the pathogenesis of migraine. Herein we describe optimization of CGRP receptor antagonists based…”
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The development of an in vitro assay to screen lipid based nanoparticles for siRNA delivery by Zhang, Ye, Arrington, Leticia, Boardman, David, Davis, Jared, Xu, Yan, DiFelice, Katie, Stirdivant, Steve, Wang, Weimin, Budzik, Brian, Bawiec, Jack, Deng, James, Beutner, Greg, Seifried, Darla, Stanton, Matthew, Gindy, Marian, Leone, Anthony

“…In order to rapidly screen and select lead candidates for in vivo evaluation of lipid nanoparticles (LNPs) for systemic small interfering RNA (siRNA) delivery,…”
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Imidazopyridine CB2 agonists: Optimization of CB2/CB1 selectivity and implications for in vivo analgesic efficacy by Trotter, B. Wesley, Nanda, Kausik K., Burgey, Christopher S., Potteiger, Craig M., Deng, James Z., Green, Ahren I., Hartnett, John C., Kett, Nathan R., Wu, Zhicai, Henze, Darrell A., Penna, Kimberly Della, Desai, Reshma, Leitl, Michael D., Lemaire, Wei, White, Rebecca B., Yeh, Suzie, Urban, Mark O., Kane, Stefanie A., Hartman, George D., Bilodeau, Mark T.

“…A new series of imidazopyridine CB2 agonists is described. Structural optimization improved CB2/CB1 selectivity in this series and conferred physical…”
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Expanding the scope of the Cu assisted Suzuki–Miyaura reaction by Crowley, Brendan M., Potteiger, Craig M., Deng, James Z., Prier, Christopher K., Paone, Daniel V., Burgey, Christopher S.

“…Recent advances in the development of the copper facilitated Suzuki–Miyaura reaction are described. Improvements include expansion of substrate scope to…”
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Synthesis of the (3R,6S)-3-Amino-6-(2,3-difluorophenyl)azepan-2-one of Telcagepant (MK-0974), a Calcitonin Gene-Related Peptide Receptor Antagonist for the Treatment of Migraine Headache by Burgey, Christopher S, Paone, Daniel V, Shaw, Anthony W, Deng, James Z, Nguyen, Diem N, Potteiger, Craig M, Graham, Samuel L, Vacca, Joseph P, Williams, Theresa M

“…Two novel routes have been developed to the (3R,6S)-3-amino-6-(2,3-difluorophenyl)-1-(2,2,2-trifluoroethyl)azepan-2-one 2 of the CGRP receptor antagonist…”
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