Search Results - "Deng, Huaxiang"

UniKP: a unified framework for the prediction of enzyme kinetic parameters by Yu, Han, Deng, Huaxiang, He, Jiahui, Keasling, Jay D., Luo, Xiaozhou

“…Prediction of enzyme kinetic parameters is essential for designing and optimizing enzymes for various biotechnological and industrial applications, but the…”
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Characterization of a novel carboxylesterase from Bacillus velezensis SYBC H47 and its application in degradation of phthalate esters by Huang, Lin, Meng, Di, Tian, Qiaopeng, Yang, Shaolan, Deng, Huaxiang, Guan, Zhengbing, Cai, Yujie, Liao, Xiangru

“…Recently, residual plasticizer phthalate esters (PAEs) in the different environments pose a serious health threat to humans and mammals. Biodegradation has…”
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Adaptive Responses to Oxidative Stress in the Filamentous Fungal Shiraia bambusicola by Deng, Huaxiang, Chen, Jiajun, Gao, Ruijie, Liao, Xiangru, Cai, Yujie

“…Shiraia bambusicola can retain excellent physiological activity when challenged with maximal photo-activated hypocrellin, which causes cellular oxidative…”
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Advances and perspectives on perylenequinone biosynthesis by Deng, Huaxiang, Liang, Xinxin, Liu, Jinbin, Zheng, Xiaohui, Fan, Tai-Ping, Cai, Yujie

“…Under illumination, the fungal secondary metabolites, perylenequinones (PQs) react with molecular oxygen to generate reactive oxygen species (ROS), which, in…”
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Enhanced hypocrellin production of Shiraia sp. SUPER-H168 by overexpression of alpha-amylase gene by Gao, Ruijie, Xu, Zhecun, Deng, Huaxiang, Guan, Zhengbing, Liao, Xiangru, Zhao, Ye, Zheng, Xiaohui, Cai, Yujie

“…Relative expression levels of twenty-four amylase genes in Shiraia sp. SUPER-H168 were investigated by real-time quantitative PCR when various carbohydrates,…”
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Identification of an indole biodegradation gene cluster from Providencia rettgeri and its contribution in selectively biosynthesizing Tyrian purple by Li, Feifei, Deng, Huaxiang, Zhong, Biming, Ruan, Banlai, Zhao, Xixi, Luo, Xiaozhou

“…Tyrian purple, mainly composed of 6, 6'-dibromoindigo, is a precious dye extracted from sea snails. In this study, we found Tyrian purple can be selectively…”
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Pathway Evolution Through a Bottlenecking‐Debottlenecking Strategy and Machine Learning‐Aided Flux Balancing by Deng, Huaxiang, Yu, Han, Deng, Yanwu, Qiu, Yulan, Li, Feifei, Wang, Xinran, He, Jiahui, Liang, Weiyue, Lan, Yunquan, Qiao, Longjiang, Zhang, Zhiyu, Zhang, Yunfeng, Keasling, Jay D., Luo, Xiaozhou

“…The evolution of pathway enzymes enhances the biosynthesis of high‐value chemicals, crucial for pharmaceutical, and agrochemical applications. However,…”
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Enhanced hypocrellin production via coexpression of alpha-amylase and hemoglobin genes in Shiraia bambusicola by Gao, Ruijie, Deng, Huaxiang, Guan, Zhengbing, Liao, Xiangru, Cai, Yujie

“…Shiraia bambusicola is an important and valuable macrofungus and hypocrellins are its main secondary metabolites which have been widely applied in many medical…”
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CRISPR system in filamentous fungi: Current achievements and future directions by Deng, Huaxiang, Gao, Ruijie, Liao, Xiangru, Cai, Yujie

“…As eukaryotes, filamentous fungi share many features with humans, and they produce numerous active metabolites, some of which are toxic. Traditional genetic…”
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Genome editing in Shiraia bambusicola using CRISPR-Cas9 system by Deng, Huaxiang, Gao, Ruijie, Liao, Xiangru, Cai, Yujie

“…•The CRISPR/Cas9 system was constructed in Shiraia sp. SUPER-H168.•A polyketide synthase was validated by this system.•The PKS is involved in hypocrellin…”
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Redox cascade reaction for kinetic resolution of racemic α-methylbenzylamine and biosynthesis of α-phenylethanol by Liu, Jinbin, Wang, Minyang, Liang, Chen, Deng, Huaxiang, Yu, Xiaohong

“…  Chiral α-methylbenzylamine and α-phenylethanol are important building blocks for the industrial production of optically active drugs, bioactive compounds…”
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Development of a novel magnetic metal-organic framework for the immobilization of short-chain dehydrogenase for the asymmetric reduction of pro-chiral ketone by Hu, Xiaoxiang, Liu, Wenjing, Yan, Yi, Deng, Huaxiang, Cai, Yujie

“…Short-chain dehydrogenase/reductase (SDR) acts as a biocatalyst in the synthesis of chiral alcohols with high optical purity. Herein, we achieved…”
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Tropinone reductase: A comprehensive review on its role as the key enzyme in tropane alkaloids biosynthesis by Hu, Xiaoxiang, Liu, Wenjing, Yan, Yi, Deng, Huaxiang, Cai, Yujie

“…TAs, including hyoscyamine and scopolamine, were used to treat neuromuscular disorders ranging from nerve agent poisoning to Parkinson's disease. Tropinone…”
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Redox cascade reaction for kinetic resolution of racemic [alpha]-methylbenzylamine and biosynthesis of [alpha]-phenylethanol by Liu, Jinbin, Wang, Minyang, Liang, Chen, Deng, Huaxiang, Yu, Xiaohong

“…Chiral [alpha]-methylbenzylamine and [alpha]-phenylethanol are important building blocks for the industrial production of optically active drugs, bioactive…”
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Highly efficient biosynthesis of spermidine from L-homoserine and putrescine using an engineered Escherichia coli with NADPH self-sufficient system by Liang, Xinxin, Deng, Huaxiang, Bai, Yajun, Fan, Tai-Ping, Zheng, Xiaohui, Cai, Yujie

“…Spermidine is an important polyamine that can be used for the synthesis of various bioactive compounds in the food and pharmaceutical fields. In this study, a…”
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A commentary on 'Local excision as a viable alternative to hysterectomy for early-stage cervical cancer in women of reproductive age: a population-based cohort study' by Zhang, Jianxia, Qiu, Huiling, Qing, Yinxia, Hu, Yanxia, Deng, Huaxiang

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A commentary on 'Clinical evaluation of balloon occlusion of the lower abdominal aorta in patients with placenta previa and previous cesarean section: a retrospective study on 43 cases' by Deng, Huaxiang, Zhang, Jianxia, Gao, Qiuyun, Qiu, Huiling, Li, Guizhen

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A commentary on 'Laparoscopic inguinal ligament suspension with uterine preservation for pelvic organ prolapse: a retrospective cohort study' by Qiu, Huiling, Hu, Yanxia, Zhang, Mengying, Deng, Huaxiang, Qing, Yinxia

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Advances and perspectives on pharmacological activities and mechanisms of the monoterpene borneol by Hu, Xiaoxiang, Yan, Yi, Liu, Wenjing, Liu, Jie, Fan, Taipin, Deng, Huaxiang, Cai, Yujie

“…Borneol, a highly lipid-soluble bicyclic terpene mainly extracted from plants, is representative of monoterpenoids. Modern medicine has established that…”
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A commentary on "The effect of biofeedback pelvic floor training with ACTICORE1 on fecal incontinence A prospective multicentric cohort pilot study" by Hu, Yanxia, Deng, Huaxiang, Li, Guizhen, Zhang, Jianxia, Zhang, Mengying

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