Search Results - "Deng, Haiteng"

Complex roles of nicotinamide N-methyltransferase in cancer progression by Wang, Weixuan, Yang, Changmei, Wang, Tianxiang, Deng, Haiteng

“…Nicotinamide N -methyltransferase (NNMT) is an intracellular methyltransferase, catalyzing the N-methylation of nicotinamide (NAM) to form 1-methylnicotinamide…”
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Identification of the cross-strand chimeric RNAs generated by fusions of bi-directional transcripts by Wang, Yuting, Zou, Qin, Li, Fajin, Zhao, Wenwei, Xu, Hui, Zhang, Wenhao, Deng, Haiteng, Yang, Xuerui

“…A major part of the transcriptome complexity is attributed to multiple types of DNA or RNA fusion events, which take place within a gene such as alternative…”
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The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1 by Han, Jinbo, Li, Erwei, Chen, Liqun, Zhang, Yuanyuan, Wei, Fangchao, Liu, Jieyuan, Deng, Haiteng, Wang, Yiguo

“…Studies in mice reveal that CREB regulated transcription coactivator 2 (CRTC2) acts as a mediator of mTOR signalling in the liver to regulate SREBP1-controlled…”
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Heterogeneity in proline hydroxylation of fibrillar collagens observed by mass spectrometry by Kirchner, Michele, Deng, Haiteng, Xu, Yujia

“…Collagen is the major protein in the extracellular matrix and plays vital roles in tissue development and function. Collagen is also one of the most processed…”
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Reciprocal interaction between SIRT6 and APC/C regulates genomic stability by Wang, Helin, Feng, Kangze, Wang, Qingtao, Deng, Haiteng

“…SIRT6 is an NAD + -dependent deacetylase that plays an important role in mitosis fidelity and genome stability. In the present study, we found that SIRT6…”
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Phase separation of RNA-binding protein promotes polymerase binding and transcription by Shao, Wen, Bi, Xianju, Pan, Yixuan, Gao, Boyang, Wu, Jun, Yin, Yafei, Liu, Zhimin, Peng, Mengyuan, Zhang, Wenhao, Jiang, Xu, Ren, Wenlin, Xu, Yanhui, Wu, Zhongyang, Wang, Kaili, Zhan, Ge, Lu, J. Yuyang, Han, Xue, Li, Tong, Wang, Jianlong, Li, Guohong, Deng, Haiteng, Li, Bing, Shen, Xiaohua

“…An RNA-involved phase-separation model has been proposed for transcription control. However, the molecular links that connect RNA to the transcription…”
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Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders by Su, Shang, Yang, Zimo, Gao, Hongying, Yang, Haiyan, Zhu, Songbiao, An, Zixuan, Wang, Juanjuan, Li, Qing, Chandarlapaty, Sarat, Deng, Haiteng, Wu, Wei, Rao, Yu

“…A focused PROTAC library hijacking cancer therapeutic target CDK6 was developed. A design principle as “match/mismatch” was proposed for understanding the…”
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Discovery of a first-in-class CDK2 selective degrader for AML differentiation therapy by Wang, Liguo, Shao, Xuejing, Zhong, Tianbai, Wu, Yue, Xu, Aixiao, Sun, Xiuyun, Gao, Hongying, Liu, Yongbo, Lan, Tianlong, Tong, Yan, Tao, Xue, Du, Wenxin, Wang, Wei, Chen, Yingqian, Li, Ting, Meng, Xianbin, Deng, Haiteng, Yang, Bo, He, Qiaojun, Ying, Meidan, Rao, Yu

“…The discovery of effective therapeutic treatments for cancer via cell differentiation instead of antiproliferation remains a great challenge. Cyclin-dependent…”
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Induced TRIM21 ISGylation by IFN-β enhances p62 ubiquitination to prevent its autophagosome targeting by Jin, Jie, Meng, Xianbin, Huo, Yi, Deng, Haiteng

“…The tripartite motif-containing protein 21 (TRIM21) plays important roles in autophagy and innate immunity. Here, we found that HECT and RLD domain containing…”
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Traceless Removal of Two Kernel Atoms in a Gold Nanocluster and Its Impact on Photoluminescence by Zhou, Yue, Liao, Lingwen, Zhuang, Shengli, Zhao, Yan, Gan, Zibao, Gu, Wanmiao, Li, Jin, Deng, Haiteng, Xia, Nan, Wu, Zhikun

“…Removing or adding kernel atoms of metal nanoclusters (NCs) without leaving a trace is a substantial challenge because the kernel atoms are inside and covered…”
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Structure of the RSC complex bound to the nucleosome by Ye, Youpi, Wu, Hao, Chen, Kangjing, Clapier, Cedric R, Verma, Naveen, Zhang, Wenhao, Deng, Haiteng, Cairns, Bradley R, Gao, Ning, Chen, Zhucheng

“…The RSC complex remodels chromatin structure and regulates gene transcription. We used cryo-electron microscopy to determine the structure of yeast RSC bound…”
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H2A.Z facilitates licensing and activation of early replication origins by Long, Haizhen, Zhang, Liwei, Lv, Mengjie, Wen, Zengqi, Zhang, Wenhao, Chen, Xiulan, Zhang, Peitao, Li, Tongqing, Chang, Luyuan, Jin, Caiwei, Wu, Guozhao, Wang, Xi, Yang, Fuquan, Pei, Jianfeng, Chen, Ping, Margueron, Raphael, Deng, Haiteng, Zhu, Mingzhao, Li, Guohong

“…DNA replication is a tightly regulated process that ensures the precise duplication of the genome during the cell cycle 1 . In eukaryotes, the licensing and…”
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Crystal Structure of NLRC4 Reveals Its Autoinhibition Mechanism by Hu, Zehan, Yan, Chuangye, Liu, Peiyuan, Huang, Zhiwei, Ma, Rui, Zhang, Chenlu, Wang, Ruiyong, Zhang, Yueteng, Martinon, Fabio, Miao, Di, Deng, Haiteng, Wang, Jiawei, Chang, Junbiao, Chai, Jijie

“…Nucleotide-binding and oligomerization domain–like receptor (NLR) proteins oligomerize into multiprotein complexes termed inflammasomes when activated. Their…”
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Nicotinamide Mononucleotide Administration Restores Redox Homeostasis via the Sirt3–Nrf2 Axis and Protects Aged Mice from Oxidative Stress-Induced Liver Injury by Luo, Chengting, Ding, Wenxi, Yang, Changmei, Zhang, Wenhao, Liu, Xiaohui, Deng, Haiteng

“…Altered adaptive homeostasis contributes to aging and lifespan regulation. In the present study, to characterize the mechanism of aging in mouse liver, we…”
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Structural basis of ultraviolet-B perception by UVR8 by Di Wu, Hu, Qi, Yan, Zhen, Chen, Wen, Yan, Chuangye, Huang, Xi, Zhang, Jing, Yang, Panyu, Deng, Haiteng, Wang, Jiawei, Deng, XingWang, Shi, Yigong

“…The Arabidopsis thaliana protein UVR8 is a photoreceptor for ultraviolet-B. Upon ultraviolet-B irradiation, UVR8 undergoes an immediate switch from homodimer…”
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The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery by Xia, Yun, Xie, Yonghua, Yu, Zhengsen, Xiao, Hongying, Jiang, Guimei, Zhou, Xiaoying, Yang, Yunyun, Li, Xin, Zhao, Meng, Li, Liping, Zheng, Mingke, Han, Shuai, Zong, Zhaoyun, Meng, Xianbin, Deng, Haiteng, Ye, Huahu, Fa, Yunzhi, Wu, Haitao, Oldfield, Eric, Hu, Xiaoyu, Liu, Wanli, Shi, Yan, Zhang, Yonghui

“…Motivated by the clinical observation that interruption of the mevalonate pathway stimulates immune responses, we hypothesized that this pathway may function…”
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Ultrasensitive Ribo-seq reveals translational landscapes during mammalian oocyte-to-embryo transition and pre-implantation development by Xiong, Zhuqing, Xu, Kai, Lin, Zili, Kong, Feng, Wang, Qiujun, Quan, Yujun, Sha, Qian-qian, Li, Fajin, Zou, Zhuoning, Liu, Ling, Ji, Shuyan, Chen, Yuling, Zhang, Hongmei, Fang, Jianhuo, Yu, Guang, Liu, Bofeng, Wang, Lijuan, Wang, Huili, Deng, Haiteng, Yang, Xuerui, Fan, Heng-yu, Li, Lei, Xie, Wei

“…In mammals, translational control plays critical roles during oocyte-to-embryo transition (OET) when transcription ceases. However, the underlying regulatory…”
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The Fourth Alloying Mode by Way of Anti‐Galvanic Reaction by Zhu, Min, Wang, Pu, Yan, Nan, Chai, Xiaoqi, He, Lizhong, Zhao, Yan, Xia, Nan, Yao, Chuanhao, Li, Jin, Deng, Haiteng, Zhu, Yan, Pei, Yong, Wu, Zhikun

“…Anti‐galvanic reaction (AGR) not only defies classic galvanic theory but is a promising method for tuning the compositions, structures, and properties of…”
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Development of the Double Cyclic Peptide Ligand for Antibody Purification and Protein Detection by Gong, Yiyi, Zhang, Lin, Li, Jin, Feng, Shan, Deng, Haiteng

“…Development of a peptide-based affinity matrix and detection reagent is important for biomedical research and the biopharmaceutical industry. In the present…”
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ShHTL7 is a non-canonical receptor for strigolactones in root parasitic weeds by Yao, Ruifeng, Wang, Fei, Ming, Zhenhua, Du, Xiaoxi, Chen, Li, Wang, Yupei, Zhang, Wenhao, Deng, Haiteng, Xie, Daoxin

“…Strigolactones （SLs） are a group of carotenoid-de- rived small molecules synthesized by plants. As a special class of plant hormones, SLs regulate shoot…”
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