Search Results - "Dendorfer, A."

Somatic gene editing ameliorates skeletal and cardiac muscle failure in pig and human models of Duchenne muscular dystrophy by Moretti, A., Fonteyne, L., Giesert, F., Hoppmann, P., Meier, A. B., Bozoglu, T., Baehr, A., Schneider, C. M., Sinnecker, D., Klett, K., Fröhlich, T., Rahman, F. Abdel, Haufe, T., Sun, S., Jurisch, V., Kessler, B., Hinkel, R., Dirschinger, R., Martens, E., Jilek, C., Graf, A., Krebs, S., Santamaria, G., Kurome, M., Zakhartchenko, V., Campbell, B., Voelse, K., Wolf, A., Ziegler, T., Reichert, S., Lee, S., Flenkenthaler, F., Dorn, T., Jeremias, I., Blum, H., Dendorfer, A., Schnieke, A., Krause, S., Walter, M. C., Klymiuk, N., Laugwitz, K. L., Wolf, E., Wurst, W., Kupatt, C.

“…Frameshift mutations in the DMD gene, encoding dystrophin, cause Duchenne muscular dystrophy (DMD), leading to terminal muscle and heart failure in patients…”
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A practical guide for investigating cardiac physiology using living myocardial slices by Watson, S. A., Dendorfer, A., Thum, T., Perbellini, F.

“…Ex vivo multicellular preparations are essential tools to study tissue physiology. Among them, the recent methodological and technological developments in…”
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Medium-chain fatty acids modulate myocardial function via a cardiac odorant receptor by Jovancevic, Nikolina, Dendorfer, A., Matzkies, M., Kovarova, M., Heckmann, J. C., Osterloh, M., Boehm, M., Weber, L., Nguemo, F., Semmler, J., Hescheler, J., Milting, H., Schleicher, E., Gelis, L., Hatt, H.

“…Several studies have demonstrated the expression of odorant receptors (OR) in various human tissues and their involvement in different physiological and…”
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Chemical and mechanical activation of resident cardiac macrophages in the living myocardial slice ex vivo model by Waleczek, F. J. G., Sansonetti, M., Xiao, K., Jung, M., Mitzka, S., Dendorfer, A., Weber, N., Perbellini, F., Thum, T.

“…Resident cardiac macrophages (rcMACs) are among the most abundant immune cells in the heart. Plasticity and activation are hallmarks of rcMACs in response to…”
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Effects of controlled ovarian stimulation on vascular barrier and endothelial glycocalyx: a pilot study by Hulde, Nikolai, Rogenhofer, N., Brettner, F., Eckert, N. C., Fetz, I., Buchheim, J-I., Kammerer, T., Dendorfer, A., Choukèr, A., Hofmann-Kiefer, K. F., Rehm, M., Thaler, C.

“…Purpose Controlled ovarian stimulation significantly amplifies the number of maturing and ovulated follicles as well as ovarian steroid production. The ovarian…”
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Combination of the PD‐1 inhibitor Nivolumab and Immunomodulatory Drug Lenalidomide in Relapsed Hodgkin and Large B‐cell Lymphoma: Results from a Phase I/II Study by Bond, D. A., Wei, L., Yildiz, V., Reneau, J., Sawalha, Y., Christian, B., Brammer, J., Epperla, N., Koff, J., Dendorfer, A., Yang, L., Baiocchi, R., Voorhees, T., Sigmund, A. M., Hanel, W., Shindiapina, P., Denlinger, N., Penza, S., Jaglowski, S., Bezerra, E., Alinari, L., Blum, K. A, Maddocks, K.

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The 'melanocyte-keratin' mystery revisited: neither normal human epidermal nor hair follicle melanocytes express keratin 16 or keratin 6 in situ by Ramot, Y., Gáspár, E., Dendorfer, A., Langbein, L., Paus, R.

“…Summary Background  Keratin family proteins are generally accepted as being restricted to epithelial cells. However, several studies have challenged this…”
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ACE inhibitors and angiotensin II receptor antagonists by Dendorfer, A, Dominiak, P, Schunkert, H

“…The biological actions of angiotensin II (ANG), the most prominent hormone of the renin-angiotensin-aldosterone system (RAAS), may promote the development of…”
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Intracoronary enalaprilat during angioplasty for acute myocardial infarction: alleviation of postischaemic neurohumoral and inflammatory stress? by Schaefer, U., Kurz, T., Bonnemeier, H., Dendorfer, A., Hartmann, F., Schunkert, H., Richardt, G.

“… Aims.  Reperfusion after myocardial ischaemia is associated with a distinct ischaemia/reperfusion injury. Since ACE‐inhibition, beyond its influence on…”
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Apstatin, a selective inhibitor of aminopeptidase P, reduces myocardial infarct size by a kinin‐dependent pathway by Wolfrum, S, Richardt, G, Dominiak, P, Katus, H A, Dendorfer, A

“…Inhibitors of the angiotensin converting enzyme (ACE) have been shown to exert their cardioprotective actions through a kinin‐dependent mechanism. ACE is not…”
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FgF23 and soluble klotho effects on the myocardium: an ex vivo study by Sen, P, D Alessio, C, Hamers, J, Sun, Z, Dendorfer, A, Merkus, D

“…Abstract Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): German Center for Cardiovascular research Background Fibroblast…”
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Effects of candesartan and enalaprilat on the organ-specific microvascular permeability during haemorrhagic shock in rats by Schumacher, J, Puchakayala, M.R., Binkowski, K, Eichler, W, Dendorfer, A, Klotz, K.-F.

“…To counteract the contribution of angiotensin II to shock-induced ischaemic organ damage pharmacologic blockade of the renin–angiotensin-system (RAS) is…”
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Interactions between the renin-angiotensin system (RAS) and the sympathetic system by Dendorfer, A, Raasch, W, Tempel, K, Dominiak, P

“…Angiotensin II is able to modulate both the presynaptic sympathetic system and the adrenal medulla resulting in an enhanced release of noradrenaline and…”
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Calcitonin gene-related peptide does not interact with sympathetic activity in myocardial ischemia by Burgdorf, Christof, Dendorfer, Andreas, Kurz, Thomas, Richardt, Gert

“…The aim of the present study was to assess whether calcitonin gene-related peptide (CGRP) modulates exocytotic norepinephrine release in ischemic myocardium…”
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Degradation of bradykinin by bovine tracheal epithelium and isolated epithelial cells by Dendorfer, A, Vordermark, D, Dominiak, P

“…The degradation of bradykinin (BK) labelled with tritiated proline at positions 2 and 3 ([3H]‐BK) was determined on the luminal surface of bovine tracheal…”
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Modeling doxorubicin-induced cardiotoxicity with human myocardial tissue slices: insights on genetic susceptibility and cardioprotection by Van Der Geest, J S A, Kelters, I R, Van Der Kaaij, N P, Dendorfer, A, Doevendans, P A F M, De Boer, T P, Van Laake, L W, Sluijter, J P G, Sampaio Pinto, V

“…Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): PSIDER and HARVEY (ZonMW)…”
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Characterization of bradykinin receptors mediating catecholamine release in PC12 cells by Dendorfer, A, Dominiak, P

“…The rat pheochromocytoma cell line PC12, which is a widely used model for analyzing stimulus-secretion coupling, was investigated for the effects of kinins on…”
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Tissue kallikrein KLK1 is expressed de novo in endothelial cells and mediates relaxation of human umbilical veins by Dedio, J, Wiemer, G, Rütten, H, Dendorfer, A, Schölkens, B A, Müller-Esterl, W, Wohlfart, P

“…Bradykinin released by the endothelium is thought to play an important local role in cardiovascular regulation. However, the molecular identity of endothelial…”
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Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC Working Group on Myocardial Function and the ESC Working Group on Cellular Biology of the Heart by van der Velden, Jolanda, Asselbergs, Folkert W, Bakkers, Jeroen, Batkai, Sandor, Bertrand, Luc, Bezzina, Connie R, Bot, Ilze, Brundel, Bianca J J M, Carrier, Lucie, Chamuleau, Steven, Ciccarelli, Michele, Dawson, Dana, Davidson, Sean M, Dendorfer, Andreas, Duncker, Dirk J, Eschenhagen, Thomas, Fabritz, Larissa, Falcão-Pires, Ines, Ferdinandy, Péter, Giacca, Mauro, Girao, Henrique, Gollmann-Tepeköylü, Can, Gyongyosi, Mariann, Guzik, Tomasz J, Hamdani, Nazha, Heymans, Stephane, Hilfiker, Andres, Hilfiker-Kleiner, Denise, Hoekstra, Alfons G, Hulot, Jean-Sébastien, Kuster, Diederik W D, van Laake, Linda W, Lecour, Sandrine, Leiner, Tim, Linke, Wolfgang A, Lumens, Joost, Lutgens, Esther, Madonna, Rosalinda, Maegdefessel, Lars, Mayr, Manuel, van der Meer, Peter, Passier, Robert, Perbellini, Filippo, Perrino, Cinzia, Pesce, Maurizio, Priori, Silvia, Remme, Carol Ann, Rosenhahn, Bodo, Schotten, Ulrich, Schulz, Rainer, Sipido, Karin R, Sluijter, Joost P G, van Steenbeek, Frank, Steffens, Sabine, Terracciano, Cesare M, Tocchetti, Carlo Gabriele, Vlasman, Patricia, Yeung, Kak Khee, Zacchigna, Serena, Zwaagman, Dayenne, Thum, Thomas

“…Cardiovascular diseases represent a major cause of morbidity and mortality, necessitating research to improve diagnostics, and to discover and test novel…”
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Bradykinin increases catecholamine release via B2 receptors by Dendorfer, A, Häuser, W, Falias, D, Dominiak, P

“…The mechanism by which bradykinin induces catecholamine release from neural tissues was investigated in two experimental models of rat origin. The rat…”
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